• 1697 Citations
  • 25 h-Index
1986 …2018
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Research Output 1986 2018

  • 1697 Citations
  • 25 h-Index
  • 66 Article
  • 1 Chapter
2018

Does apicortin, a characteristic protein of apicomplexan parasites and placozoa, occur in Eumetazoa?

Orosz, F., Sep 25 2018, In : Acta Parasitologica. 63, 3, p. 617-633 17 p.

Research output: Contribution to journalArticle

Placozoa
Cnidaria
Parasites
Apicomplexa
Horizontal Gene Transfer
2017
4 Citations (Scopus)

Tubulin Binding and Polymerization Promoting Properties of Tubulin Polymerization Promoting Proteins Are Evolutionarily Conserved

Oláh, J., Szénási, T., Szabó, A., Kovács, K., Lőw, P., Štifanić, M. & Orosz, F., Feb 21 2017, In : Biochemistry. 56, 7, p. 1017-1024 8 p.

Research output: Contribution to journalArticle

Tubulin
Polymerization
Proteins
Intrinsically Disordered Proteins
Porifera
2016
3 Citations (Scopus)

Wider than Thought Phylogenetic Occurrence of Apicortin, A Characteristic Protein of Apicomplexan Parasites

Orosz, F., Jun 9 2016, (Accepted/In press) In : Journal of Molecular Evolution. p. 1-12 12 p.

Research output: Contribution to journalArticle

Firearms
Transcriptome
transcriptome
Spizellomyces
Placozoa
2015
5 Citations (Scopus)

On the tubulin polymerization promoting proteins of zebrafish

Orosz, F., Feb 13 2015, In : Biochemical and Biophysical Research Communications. 457, 3, p. 267-272 6 p.

Research output: Contribution to journalArticle

Zebrafish Proteins
Tubulin
Polymerization
Genes
Fishes
8 Citations (Scopus)
Sarcocystidae
Vertebrates
Apicoplasts
Genome
Parasites
2013
13 Citations (Scopus)

Moonlighting microtubule-associated proteins: Regulatory functions by day and pathological functions at night

Oláh, J., Tokési, N., Lehotzky, A., Orosz, F. & Ovádi, J., Nov 2013, In : Cytoskeleton. 70, 11, p. 677-685 9 p.

Research output: Contribution to journalArticle

Microtubule-Associated Proteins
Microtubules
Cytoskeleton
Tubulin
Proteins
2012
4 Citations (Scopus)

A fish-specific member of the TPPP protein family?

Orosz, F., Aug 2012, In : Journal of Molecular Evolution. 75, 1-2, p. 55-72 18 p.

Research output: Contribution to journalArticle

Tubulin
tubulin
polymerization
Polymerization
Fishes
12 Citations (Scopus)

A New Protein Superfamily: TPPP-Like Proteins

Orosz, F., Nov 14 2012, In : PLoS One. 7, 11, e49276.

Research output: Contribution to journalArticle

Tubulin
tubulin
Polymerization
polymerization
Proteins
10 Citations (Scopus)

Microtubule assembly-derived by dimerization of TPPP/p25. Evaluation of thermodynamic parameters for multiple equilibrium system from ITC data

Oláh, J., Zotter, Á., Hlavanda, E., Szunyogh, S., Orosz, F., Szigeti, K., Fidy, J. & Ovádi, J., Jul 2012, In : BBA - General Subjects. 1820, 7, p. 785-794 10 p.

Research output: Contribution to journalArticle

Dimerization
Tubulin
Thermodynamics
Information Systems
Microtubules
2011
5 Citations (Scopus)

Apicomplexan apicortins possess a long disordered N-terminal extension

Orosz, F., Jul 2011, In : Infection, Genetics and Evolution. 11, 5, p. 1037-1044 8 p.

Research output: Contribution to journalArticle

Spizellomyces
Toxoplasma
protein
Placozoa
Plasmodium
21 Citations (Scopus)

Disordered TPPP/p25 binds GTP and displays Mg2+-dependent GTPase activity

Zotter, Á., Bodor, A., Oláh, J., Hlavanda, E., Orosz, F., Perczel, A. & Ovádi, J., Mar 9 2011, In : FEBS Letters. 585, 5, p. 803-808 6 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Tubulin
Guanosine Triphosphate
Polymerization
Physiological Phenomena
23 Citations (Scopus)

From "fluctuation fit" to "conformational selection": Evolution, rediscovery, and integration of a concept

Vértessy, B. & Orosz, F., Jan 2011, In : BioEssays. 33, 1, p. 30-34 5 p.

Research output: Contribution to journalArticle

Macromolecular Substances
Protein folding
Ligands
Kinetics
Protein Binding
67 Citations (Scopus)

Interactions of pathological hallmark proteins: Tubulin polymerization promoting protein/p25,β-amyloid, and α-synuclein

Oláh, J., Vincze, O., Virók, D., Simon, D., Bozsó, Z., Tokési, N., Horváth, I., Hlavanda, E., Kovács, J., Magyar, A., Szücs, M., Orosz, F., Penke, B. & Ovádi, J., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 34088-34100 13 p.

Research output: Contribution to journalArticle

Synucleins
Amyloidogenic Proteins
Tubulin
Amyloid
Polymerization
25 Citations (Scopus)

Proteins without 3D structure: Definition, detection and beyond

Orosz, F. & Ovádi, J., Jun 2011, In : Bioinformatics. 27, 11, p. 1449-1454 6 p., btr175.

Research output: Contribution to journalArticle

Intrinsically Disordered Proteins
Proteins
Protein
Genes
Disorder
4 Citations (Scopus)

Reappraisal of triosephosphate isomerase deficiency

Orosz, F., Oláh, J. & Ovádi, J., Mar 2011, In : European Journal of Haematology. 86, 3, p. 265-267 3 p.

Research output: Contribution to journalArticle

Congenital Hemolytic Anemia
Triose-Phosphate Isomerase
Protein Conformation
Nonsense Codon
Homozygote
2009
32 Citations (Scopus)

An unstructured protein with destructive potential: TPPP/p25 in neurodegeneration

Ovádi, J. & Orosz, F., 2009, In : BioEssays. 31, 6, p. 676-686 11 p.

Research output: Contribution to journalArticle

Intrinsically Disordered Proteins
Brain
Oligodendroglia
Central Nervous System Diseases
Cytomegalovirus Infections
12 Citations (Scopus)
Placozoa
parasite
Parasites
parasites
protein
79 Citations (Scopus)
Triose-Phosphate Isomerase
Mutation
Dihydroxyacetone Phosphate
Pyruvaldehyde
Pentose Phosphate Pathway
2008
1 Citation (Scopus)

Energy Metabolism in Conformational Diseases

Ovádi, J. & Orosz, F., Jul 11 2008, Biosimulation in Drug Development. Wiley-VCH Verlag GmbH & Co. KGaA, p. 233-257 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Protein Unfolding
Energy Metabolism
Brain
Neurodegenerative diseases
Physiological Phenomena
41 Citations (Scopus)

Increased glucose metabolism and ATP level in brain tissue of Huntington's disease transgenic mice

Oláh, J., Klivényi, P., Gardián, G., Vécsei, L., Orosz, F., Kovacs, G. G., Westerhoff, H. V. & Ovádi, J., Oct 2008, In : FEBS Journal. 275, 19, p. 4740-4755 16 p.

Research output: Contribution to journalArticle

Huntington Disease
Metabolism
Transgenic Mice
Brain
Adenosine Triphosphate
10 Citations (Scopus)

Progress in the development of early diagnosis and a drug with unique pharmacology to improve cancer therapy

Lehotzky, A., Tokési, N., Gonzalez-Alvarez, I., Merino, V., Bermejo, M., Orosz, F., Lau, P., Kovacs, G. G. & Ovádi, J., Oct 13 2008, In : Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 366, 1880, p. 3599-3617 19 p.

Research output: Contribution to journalArticle

pharmacology
Pharmacology
Therapy
therapy
Cancer
16 Citations (Scopus)

TPPP orthologs are ciliary proteins

Orosz, F. & Ovádi, J., Nov 12 2008, In : FEBS Letters. 582, 27, p. 3757-3764 8 p.

Research output: Contribution to journalArticle

Cilia
Genes
Proteins
Flagella
Oligodendroglia
2007
43 Citations (Scopus)

Interactions of enolase isoforms with tubulin and microtubules during myogenesis

Keller, A., Peltzer, J., Carpentier, G., Horváth, I., Oláh, J., Duchesnay, A., Orosz, F. & Ovádi, J., Jun 2007, In : BBA - General Subjects. 1770, 6, p. 919-926 8 p.

Research output: Contribution to journalArticle

Muscle Development
Phosphopyruvate Hydratase
Tubulin
Microtubules
Protein Isoforms
46 Citations (Scopus)

Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): Identification of sites targeted by different kinases

Hlavanda, E., Klement, E., Kókai, E., Kovács, J., Vincze, O., Tokési, N., Orosz, F., Medzihradszky, K. F., Dombrádi, V. & Ovádi, J., Oct 5 2007, In : Journal of Biological Chemistry. 282, 40, p. 29531-29539 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Tubulin
Polymerization
Phosphotransferases
Cyclin-Dependent Kinase 5
25 Citations (Scopus)

Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies

Oláh, J., Tokési, N., Vincze, O., Horváth, I., Lehotzky, A., Erdei, A., Szájli, E., Medzihradszky, K. F., Orosz, F., Kovács, G. G. & Ovádi, J., Oct 30 2006, In : FEBS Letters. 580, 25, p. 5807-5814 8 p.

Research output: Contribution to journalArticle

Lewy Bodies
Glyceraldehyde-3-Phosphate Dehydrogenases
Proteins
Synucleins
Intrinsically Disordered Proteins
10 Citations (Scopus)

New anti-mitotic drugs with distinct anti-calmodulin activity

Orosz, F., Horváth, I. & Ovádi, J., Oct 2006, In : Mini-Reviews in Medicinal Chemistry. 6, 10, p. 1145-1157 13 p.

Research output: Contribution to journalArticle

Calmodulin
Microtubules
Vinca Alkaloids
Derivatives
Spindle Apparatus
74 Citations (Scopus)

Triosephosphate isomerase deficiency: Facts and doubts

Orosz, F., Oláh, J. & Ovádi, J., Dec 2006, In : IUBMB Life. 58, 12, p. 703-715 13 p.

Research output: Contribution to journalArticle

Triose-Phosphate Isomerase
Mutation
Heterozygote
Glyceraldehyde 3-Phosphate
Dihydroxyacetone Phosphate
55 Citations (Scopus)

Tubulin polymerization promoting proteins (TPPPs): Members of a new family with distinct structures and functions

Vincze, O., Tökési, N., Oláh, J., Hlavanda, E., Zotter, Á., Horváth, I., Lehotzky, A., Tirián, L., Medzihradszky, K. F., Kovács, J., Orosz, F. & Ovádi, J., Nov 21 2006, In : Biochemistry. 45, 46, p. 13818-13826 9 p.

Research output: Contribution to journalArticle

Tubulin
Polymerization
Proteins
Microtubules
Mammals
2005
4 Citations (Scopus)

Is there an answer? What is the biological significance of the brain-specific tubulin-polymerization promoting protein (TPPP/p25)?

Ovádi, J., Orosz, F. & Lebotzky, A., Nov 2005, In : IUBMB Life. 57, 11, p. 765-768 4 p.

Research output: Contribution to journalArticle

Nerve Tissue Proteins
Tubulin
HeLa Cells
Polymerization
Brain
35 Citations (Scopus)
Triose-Phosphate Isomerase
Siblings
Messenger RNA
Mutation
Dihydroxyacetone Phosphate
2004
32 Citations (Scopus)
Mutant Proteins
Cell membranes
Mutation
Enzymes
Cell Membrane
16 Citations (Scopus)

Methotrexate inhibits the glyoxalase system in vivo in children with acute lymphoid leukaemia

Bartyik, K., Túri, S., Orosz, F. & Karg, E., Oct 2004, In : European Journal of Cancer. 40, 15, p. 2287-2292 6 p.

Research output: Contribution to journalArticle

Lactoylglutathione Lyase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Methotrexate
Lactic Acid
Pyruvaldehyde
42 Citations (Scopus)

TPPP/p25: From unfolded protein to misfolding disease: Prediction and experiments

Orosz, F., Kovács, G. G., Lehotzky, A., Oláh, J., Vincze, O. & Ovádi, J., Dec 2004, In : Biology of the Cell. 96, 9, p. 701-711 11 p.

Research output: Contribution to journalArticle

Proteostasis Deficiencies
Synucleins
Intrinsically Disordered Proteins
Inclusion Bodies
Tubulin
2003
8 Citations (Scopus)

Glucose conversion by multiple pathways in brain extract: Theoretical and experimental analysis

Orosz, F., Wágner, G., Ortega, F., Cascante, M. & Ovádi, J., Oct 3 2003, In : Biochemical and Biophysical Research Communications. 309, 4, p. 792-797 6 p.

Research output: Contribution to journalArticle

Hexokinase
Pentosephosphates
Glucose-6-Phosphate
Glycolysis
Brain
81 Citations (Scopus)
Spindle Apparatus
Tubulin
Proteins
Centrosome
Microtubules
2002
35 Citations (Scopus)

A simple method for the determination of dissociation constants by displacement ELISA

Orosz, F. & Ovádi, J., Dec 15 2002, In : Journal of Immunological Methods. 270, 2, p. 155-162 8 p.

Research output: Contribution to journalArticle

Enzyme-Linked Immunosorbent Assay
Serum
Antigens
Hexokinase
Antibodies
89 Citations (Scopus)

Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations

Hlavanda, E., Kovács, J., Oláh, J., Orosz, F., Medzihradszky, K. F. & Ovádi, J., Jul 9 2002, In : Biochemistry. 41, 27, p. 8657-8664 8 p.

Research output: Contribution to journalArticle

Tubulin
Microtubules
Brain
Proteins
Polymerization
48 Citations (Scopus)

Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease.

Oláh, J., Orosz, F., Keserü, G. M., Kovári, Z., Kovács, J., Hollán, S. & Ovádi, J., Apr 2002, In : Biochemical Society Transactions. 30, 2, p. 30-38 9 p.

Research output: Contribution to journalArticle

Triose-Phosphate Isomerase
Neurodegenerative diseases
Neurodegenerative Diseases
Mutation
Enzymes
2001
26 Citations (Scopus)

Distinct behavior of mutant triosephosphate isomerase in hemolysate and in isolated form: Molecular basis of enzyme deficiency

Orosz, F., Oláh, J., Alvarez, M., Keserü, G. M., Szabó, B., Wágner, G., Kovári, Z., Horányi, M., Baróti, K., Martial, J. A., Hollán, S. & Ovádi, J., Nov 15 2001, In : Blood. 98, 10, p. 3106-3112 7 p.

Research output: Contribution to journalArticle

Triose-Phosphate Isomerase
Enzymes
Heterozygote
Microtubules
Siblings
30 Citations (Scopus)

Tubulin and microtubule are potential targets for brain hexokinase binding

Wágner, G., Kovács, J., Lőw, P., Orosz, F. & Ovádi, J., Nov 30 2001, In : FEBS Letters. 509, 1, p. 81-84 4 p.

Research output: Contribution to journalArticle

Hexokinase
Tubulin
Microtubules
Brain
Association reactions
2000
43 Citations (Scopus)
Triose-Phosphate Isomerase
Nervous System Diseases
Microtubules
Glyceraldehyde 3-Phosphate
Cell Membrane
23 Citations (Scopus)

Quantitative characterization of homo- and heteroassociations of muscle phosphofructokinase with aldolase

Raïs, B., Ortega, F., Puigjaner, J., Comin, B., Orosz, F., Ovádi, J. & Cascante, M., Jun 15 2000, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1479, 1-2, p. 303-314 12 p.

Research output: Contribution to journalArticle

Phosphofructokinases
Fructose-Bisphosphate Aldolase
Muscle
Muscles
Phosphotransferases
1999
25 Citations (Scopus)
Metabolism
Microtubules
Toxicity
Copper
Glucose
22 Citations (Scopus)

New semisynthetic vinca alkaloids: Chemical, biochemical and cellular studies

Orosz, F., Comin, B., Raïs, B., Puigjaner, J., Kovács, J., Tárkányi, G., Ács, T., Keve, T., Cascante, M. & Ovádi, J., 1999, In : British Journal of Cancer. 79, 9-10, p. 1356-1365 10 p.

Research output: Contribution to journalArticle

Vinca Alkaloids
Calmodulin
Vinblastine
Vincristine
Microtubules
12 Citations (Scopus)

Phosphofructokinase from Dictyostelium discoideum is a potent inhibitor of tubulin polymerization

Orosz, F., Santamaría, B., Ovádi, J. & Aragón, J. J., Feb 9 1999, In : Biochemistry. 38, 6, p. 1857-1865 9 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Phosphofructokinases
Dictyostelium
Tubulin
Microtubules
1998
58 Citations (Scopus)
Trifluoperazine
Calmodulin
Vinblastine
Pharmaceutical Preparations
Molecules
1997
64 Citations (Scopus)
Phosphofructokinases
Fructose-Bisphosphate Aldolase
Microtubules
Enzymes
Phosphotransferases
27 Citations (Scopus)

Characterization of microtubule - Phosphofructokinase complex: Specific effects of MgATP and vinblastine

Vértessy, B. G., Kovács, J., Löw, P., Lehotzky, A., Molnár, A., Orosz, F. & Ovádi, J., Feb 25 1997, In : Biochemistry. 36, 8, p. 2051-2062 12 p.

Research output: Contribution to journalArticle

Phosphofructokinases
Vinblastine
Tubulin
Microtubules
Adenosine Triphosphate
23 Citations (Scopus)

Interaction of a new bis-indol derivative, KAR-2 with tubulin and its antimitotic activity

Orosz, F., Kovács, J., Lőw, P., Vértessy, B., Urbányi, Z., Ács, T., Keve, T. & Ovádi, J., 1997, In : British Journal of Pharmacology. 121, 5, p. 947-954 8 p.

Research output: Contribution to journalArticle

Antimitotic Agents
Tubulin
Microtubules
Phosphofructokinase-1
Sf9 Cells