• 2881 Citations
  • 31 h-Index
1989 …2020

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2019

PARP inhibitor PJ34 protects mitochondria and induces DNA-damage mediated apoptosis in combination with cisplatin or temozolomide in B16F10 melanoma cells

Cseh, A. M., Fabian, Z., Quintana-Cabrera, R., Szabo, A., Eros, K., Soriano, M. E., Gallyas, F., Scorrano, L. & Sumegi, B., Jan 1 2019, In : Frontiers in Physiology. 10, MAY, 538.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

PARP inhibitor protects against chronic hypoxia/ reoxygenation-induced retinal injury by regulation of MAPKs, HIF1α, Nrf2, and NFjB

Kovacs, K., Vaczy, A., Fekete, K., Petra Kovari, K., Atlasz, T., Reglodi, D., Gabriel, R., Gallyas, F. & Sumegi, B., Apr 2019, In : Investigative Ophthalmology and Visual Science. 60, 5, p. 1478-1490 13 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2018

Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases

Szabó, A., Sumegi, K., Fekete, K., Hocsak, E., Debreceni, B., Setalo, G., Kovacs, K., Deres, L., Kengyel, A., Kovacs, D., Mandl, J., Nyitrai, M., Febbraio, M. A., Gallyas, F. & Sümegi, B., Apr 1 2018, In : Biochemical Pharmacology. 150, p. 86-96 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Experimental demyelination and axonal loss are reduced in MicroRNA-146a deficient mice

Martin, N. A., Molnar, V., Szilagyi, G. T., Elkjaer, M. L., Nawrocki, A., Okarmus, J., Wlodarczyk, A., Thygesen, E. K., Palkovits, M., Gallyas, F., Larsen, M. R., Lassmann, H., Benedikz, E., Owens, T., Svenningsen, A. F. & Illes, Z., Mar 12 2018, In : Frontiers in immunology. 9, MAR, 490.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Orthologous proteins of experimental de- and remyelination are differentially regulated in the CSF proteome of multiple sclerosis subtypes

Martin, N. A., Nawrocki, A., Molnar, V., Elkjaer, M. L., Thygesen, E. K., Palkovits, M., Acs, P., Sejbaek, T., Nielsen, H. H., Hegedus, Z., Sellebjerg, F., Molnar, T., Barbosa, E. G. V., Alcaraz, N., Gallyas, F., Svenningsen, A. F., Baumbach, J., Lassmann, H., Larsen, M. R. & Illes, Z., Aug 2018, In : PloS one. 13, 8, e0202530.

Research output: Contribution to journalArticle

3 Citations (Scopus)
4 Citations (Scopus)
2017

BGP-15 protects against oxidative stress- or lipopolysaccharide-induced mitochondrial destabilization and reduces mitochondrial production of reactive oxygen species

Sumegi, K., Fekete, K., Antus, C., Debreceni, B., Hocsak, E., Gallyas, F., Sumegi, B. & Szabó, A., Jan 1 2017, In : PLoS One. 12, 1, e0169372.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Chronic PARP-1 inhibition reduces carotid vessel remodeling and oxidative damage of the dorsal hippocampus in spontaneously hypertensive rats

Eros, K., Magyar, K., Deres, L., Skazel, A., Riba, A., Vamos, Z., Kalai, T., Gallyas, F., Sümegi, B., Tóth, K. & Halmosi, R., Mar 1 2017, In : PLoS One. 12, 3, e0174401.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Desethylamiodarone—A metabolite of amiodarone—Induces apoptosis on T24 human bladder cancer cells via multiple pathways

Bognár, Z., Fekete, K., Antus, C., Hocsak, E., Bognar, R., Tapodi, A., Boronkai, A., Farkas, N., Gallyas, F., Sümegi, B. & Szanto, A., Dec 1 2017, In : PLoS One. 12, 12, e0189470.

Research output: Contribution to journalArticle

11 Citations (Scopus)

PARP inhibition protects mitochondria and reduces ROS production via PARP-1-ATF4-MKP-1-MAPK retrograde pathway

Hocsak, E., Szabo, V., Kalman, N., Antus, C., Cseh, A., Sumegi, K., Eros, K., Hegedűs, Z., Gallyas, F., Sümegi, B. & Rácz, B., Jul 1 2017, In : Free Radical Biology and Medicine. 108, p. 770-784 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2015

Cold atmospheric plasma induces a predominantly necrotic cell death via the microenvironment

Virard, F., Cousty, S., Cambus, J. P., Valentin, A., Kémoun, P., Clément, F. & Gallyas, F., Aug 14 2015, In : PLoS One. 10, 8, e0133120.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Cyclophilin D disruption attenuates lipopolysaccharide-induced inflammatory response in primary mouse macrophages

Priber, J., Fonai, F., Jakus, P. B., Racz, B., Chinopoulos, C., Tretter, L., Gallyas, F., Sumegi, B. & Veres, B., Jan 23 2015, In : Biochemistry and Cell Biology. 93, 3, p. 241-250 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Role of mitochondrial network stabilisation by a human small heat shock protein in tumour malignancy

Turi, Z., Hocsak, E., Racz, B., Szabo, A., Balogh, A., Sumegi, B. & Gallyas, F., Jan 1 2015, In : Journal of Cancer. 6, 5, p. 470-476 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The role of intermittent hypoxia on the proliferative inhibition of rat cerebellar astrocytes

Chiu, S. C., Lin, Y. J., Huang, S. Y., Lien, C. F., Chen, S. P., Pang, C. Y., Lin, J. H., Yang, K. T. & Gallyas, F., Jul 14 2015, In : PLoS One. 10, 7, e0132263.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Thymic atrophy and apoptosis of CD4+ CD8+ thymocytes in the cuprizone model of multiple sclerosis

Solti, I., Kvell, K., Talaber, G., Veto, S., Acs, P., Gallyas, F., Illes, Z., Fekete, K., Zalan, P., Szanto, A. & Bognar, Z., Jun 8 2015, In : PloS one. 10, 6, e0129217.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2014
14 Citations (Scopus)

Novel mechanisms of sildenafil in pulmonary hypertension involving cytokines/chemokines, MAP kinases and Akt

Kiss, T., Kovacs, K., Komocsi, A., Tornyos, A., Zalan, P., Sumegi, B. & Gallyas, F., Aug 18 2014, In : PloS one. 9, 8, e104890.

Research output: Contribution to journalArticle

25 Citations (Scopus)
17 Citations (Scopus)
2013

Antioxidant and Anti-Inflammatory Effects in RAW264.7 Macrophages of Malvidin, a Major Red Wine Polyphenol

Bognar, E., Sarszegi, Z., Szabo, A., Debreceni, B., Kalman, N., Tucsek, Z., Sumegi, B. & Gallyas, F., Jun 5 2013, In : PloS one. 8, 6, e65355.

Research output: Contribution to journalArticle

84 Citations (Scopus)

PARP inhibition attenuates acute kidney allograft rejection by suppressing cell death pathways and activating PI-3K-Akt cascade

Kalmar-Nagy, K., Degrell, P., Szabo, A., Sumegi, K., Wittmann, I., Gallyas, F. & Sumegi, B., Dec 3 2013, In : PloS one. 8, 12, e81928.

Research output: Contribution to journalArticle

9 Citations (Scopus)

TRAF6 is functional in inhibition of TLR4-mediated NF-κB activation by resveratrol

Jakus, P. B., Kalman, N., Antus, C., Radnai, B., Tucsek, Z., Gallyas, F., Sumegi, B. & Veres, B., May 1 2013, In : Journal of Nutritional Biochemistry. 24, 5, p. 819-823 5 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2012

BGP-15, a PARP-inhibitor, prevents imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases

Sarszegi, Z., Bognar, E., Gaszner, B., Kónyi, A., Gallyas, F., Sumegi, B. & Berente, Z., Jun 1 2012, In : Molecular and Cellular Biochemistry. 365, 1-2, p. 129-137 9 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

High-throughput screening of saliva for early detection of oral cancer: A pilot study

Szanto, I., Mark, L., Bona, A., Maasz, G., Sandor, B., Gelencser, G., Turi, Z. & Gallyas, J., Apr 2012, In : Technology in Cancer Research and Treatment. 11, 2, p. 181-188 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
10 Citations (Scopus)
2011

Beszámoló a Környey Társaság 2011. Evi tudományos ülésérol. 1. Rész.

Translated title of the contribution: [Report from the 2011 scientific meeting of the Környey Society. Part 1].Pálffy, G., Poór, G., Környey, E., Illés, Z., Kopa, J., Kovács, N., Barzo, P., Bereczki, D., Bodosi, M., Csiba, L., Dóczi, T., Fekete, S., Gallyas, F., Hegedus, K., Komoly, S., Szirmai, I. & Vécsei, L., Nov 30 2011, In : Ideggyógyászati szemle. 64, 11-12, p. 418-426 9 p.

Research output: Contribution to journalArticle

Induction of mitochondrial destabilization and necrotic cell death by apolar mitochondria-directed SOD mimetics

Szabo, A., Balog, M., Mark, L., Montsko, G., Turi, Z., Gallyas, F., Sumegi, B., Kalai, T., Hideg, K. & Kovacs, K., May 1 2011, In : Mitochondrion. 11, 3, p. 476-487 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Suppressing LPS-induced early signal transduction in macrophages by a polyphenol degradation product: A critical role of MKP-1

Tucsek, Z., Radnai, B., Racz, B., Debreceni, B., Priber, J. K., Dolowschiak, T., Palkovics, T., Gallyas, F., Sumegi, B. & Veres, B., Jan 1 2011, In : Journal of Leukocyte Biology. 89, 1, p. 105-111 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2010
22 Citations (Scopus)
23 Citations (Scopus)

Inhibiting poly(ADP-ribose) polymerase: A potential therapy against oligodendrocyte death

Veto, S., Acs, P., Bauer, J., Lassmann, H., Berente, Z., Setalo, G., Borgulya, G., Sumegi, B., Komoly, S., Gallyas, F. & Illes, Z., Mar 1 2010, In : Brain. 133, 3, p. 822-834 13 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

PACAP ameliorates oxidative stress in the chicken inner ear: An in vitro study

Racz, B., Horvath, G., Reglodi, D., Gasz, B., Kiss, P., Gallyas, F., Sumegi, B., Toth, G., Nemeth, A., Lubics, A. & Tamas, A., Feb 25 2010, In : Regulatory Peptides. 160, 1-3, p. 91-98 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
62 Citations (Scopus)

Regulation of MKP-1 expression and MAPK activation by PARP-1 in oxidative stress: A new mechanism for the cytoplasmic effect of PARP-1 activation

Racz, B., Hanto, K., Tapodi, A., Solti, I., Kalman, N., Jakus, P., Kovacs, K., Debreceni, B., Gallyas, F. & Sumegi, B., Dec 15 2010, In : Free Radical Biology and Medicine. 49, 12, p. 1978-1988 11 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

TIP47 confers resistance to taxol-induced cell death by preventing the nuclear translocation of AIF and Endonuclease G

Hocsak, E., Racz, B., Szabo, A., Pozsgai, E., Szigeti, A., Szigeti, E., Gallyas, F., Sumegi, B., Javor, S. & Bellyei, S., Nov 1 2010, In : European Journal of Cell Biology. 89, 11, p. 853-861 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

TIP47 protects mitochondrial membrane integrity and inhibits oxidative-stress-induced cell death

Hocsak, E., Racz, B., Szabo, A., Mester, L., Rapolti, E., Pozsgai, E., Javor, S., Bellyei, S., Gallyas, F., Sumegi, B. & Szigeti, A., Jul 1 2010, In : FEBS letters. 584, 13, p. 2953-2960 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2009

Alcohol-free red wine inhibits isoproterenol-induced cardiac remodeling in rats by the regulation of Akt1 and protein kinase C α/β II

Palfi, A., Bartha, E., Copf, L., Mark, L., Gallyas, F., Veres, B., Kalman, E., Pajor, L., Toth, K., Ohmacht, R. & Sumegi, B., Jun 1 2009, In : Journal of Nutritional Biochemistry. 20, 6, p. 418-425 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Critical role of bad phosphorylation by akt in cytostatic resistance of human bladder cancer cells

Szanto, A., Bognar, Z., Szigeti, A., Szabo, A., Farkas, L. & Gallyas, F., Jan 1 2009, In : Anticancer research. 29, 1, p. 159-164 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Ferulaldehyde, a water-soluble degradation product of polyphenols, inhibits the lipopolysaccharide-induced inflammatory response in mice

Radnai, B., Tucsek, Z., Bognar, Z., Antus, C., Mark, L., Berente, Z., Gallyas, F., Sumegi, B. & Veres, B., Feb 1 2009, In : Journal of Nutrition. 139, 2, p. 291-297 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

PARP-1 inhibition-induced activation of PI-3-kinase-Akt pathway promotes resistance to taxol

Szanto, A., Hellebrand, E. E., Bognar, Z., Tucsek, Z., Szabo, A., Gallyas, F., Sumegi, B. & Varbiro, G., Apr 15 2009, In : Biochemical Pharmacology. 77, 8, p. 1348-1357 10 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
23 Citations (Scopus)

Prevalent role of Akt and ERK activation in cardioprotective effect of Ca2+ channel- and beta-adrenergic receptor blockers

Kovacs, K., Hanto, K., Bognar, Z., Tapodi, A., Bognar, E., Kiss, G. N., Szabo, A., Rappai, G., Kiss, T., Sumegi, B. & Gallyas, F., Jan 1 2009, In : Molecular and Cellular Biochemistry. 321, 1-2, p. 155-164 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
35 Citations (Scopus)
2008

Effects of PACAP on the circadian changes of signaling pathways in chicken pinealocytes

Racz, B., Horvath, G., Faluhelyi, N., Nagy, A. D., Tamas, A., Kiss, P., Gallyas, F., Toth, G., Gaszner, B., Csernus, V. & Reglodi, D., Nov 1 2008, In : Journal of Molecular Neuroscience. 36, 1-3, p. 220-226 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
46 Citations (Scopus)
2007
21 Citations (Scopus)
43 Citations (Scopus)

Hyperosmotic stress-induced apoptotic signaling pathways in chondrocytes

Racz, B., Reglodi, D., Fodor, B., Gasz, B., Lubics, A., Gallyas, F., Roth, E. & Borsiczky, B., Jun 1 2007, In : Bone. 40, 6, p. 1536-1543 8 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
33 Citations (Scopus)

Preventing apoptotic cell death by a novel small heat shock protein

Bellyei, S., Szigeti, A., Pozsgai, E., Boronkai, A., Gomori, E., Hocsak, E., Farkas, R., Sumegi, B. & Gallyas, F., Mar 13 2007, In : European Journal of Cell Biology. 86, 3, p. 161-171 11 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)