• 525 Citations
  • 14 h-Index
1992 …2019

Research output per year

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Research Output

  • 525 Citations
  • 14 h-Index
  • 34 Article
  • 2 Review article
  • 1 Conference contribution
  • 1 Comment/debate
2019

Accelerated molecular dynamics applied to the peptaibol folding problem

Tyagi, C., Marik, T., Vágvölgyi, C., Kredics, L. & Ötvös, F., Sep 1 2019, In : International journal of molecular sciences. 20, 17, 4268.

Research output: Contribution to journalArticle

Open Access

Biochemical and pharmacological investigation of novel nociceptin/OFQ analogues and N/OFQ-RYYRIK hybrid peptides

Erdei, A. I., Borbély, A., Magyar, A., Szűcs, E., Ötvös, F., Gombos, D., Al-Khrasani, M., Stefanucci, A., Dimmito, M. P., Luisi, G., Mollica, A. & Benyhe, S., Feb 2019, In : Peptides. 112, p. 106-113 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access
4 Citations (Scopus)
2 Citations (Scopus)
2018

Biochemical and pharmacological characterization of three opioid-nociceptin hybrid peptide ligands reveals substantially differing modes of their actions

Erdei, A., Borbély, A., Magyar, A., Taricska, N., Perczel, A., Zsíros, O., Garab, G., Szűcs, E., Ötvös, F., Zádor, F., Balogh, M., Al-Khrasani, M. & Benyhe, S., Jan 1 2018, In : Peptides. 99, p. 205-216 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

Chaperone co-inducer BGP-15 inhibits histone deacetylases and enhances the heat shock response through increased chromatin accessibility

Budzyński, M. A., Crul, T., Himanen, S. V., Toth, N., Otvos, F., Sistonen, L. & Vigh, L., Sep 1 2017, In : Cell Stress and Chaperones. 22, 5, p. 717-728 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

Reversible Opening of Intercellular Junctions of Intestinal Epithelial and Brain Endothelial Cells with Tight Junction Modulator Peptides

Bocsik, A., Walter, F. R., Gyebrovszki, A., Fülöp, L., Blasig, I., Dabrowski, S., Ötvös, F., Tóth, A., Rákhely, G., Veszelka, S., Vastag, M., Szabó-Révész, P. & Deli, M., Feb 1 2016, In : Journal of Pharmaceutical Sciences. 105, 2, p. 754-765 12 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2015

Biochemistry of opioid (morphine) receptors: Binding, structure and molecular modelling

Benyhe, S., Zádor, F. & Ötvös, F., 2015, In : Acta Biologica Szegediensis. 59, p. 17-37 21 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2014

A case study for biochemical application porting in european grids and clouds

Kertesz, A., Otvos, F. & Kacsuk, P., Jul 2014, In : Concurrency Computation Practice and Experience. 26, 10, p. 1730-1743 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2013

Divalent heavy metal cations block the TRPV1 Ca2+ channel

Pecze, L., Winter, Z., Jósvay, K., Ötvös, F., Kolozsi, C., Vizler, C., Budai, D., Letoha, T., Dombi, G., Szakonyi, G. & Oláh, Z., Jan 1 2013, In : Biological Trace Element Research. 151, 3, p. 451-461 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Functionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel - an overview of the current mutational data

Winter, Z., Buhala, A., Ötvös, F., Jósvay, K., Vizler, C., Dombi, G., Szakonyi, G. & Oláh, Z., Jun 22 2013, In : Molecular Pain. 9, 1, 30.

Research output: Contribution to journalReview article

40 Citations (Scopus)
2012

Homology modeling and phylogenetic relationships of catalases of an opportunistic pathogen Rhizopus oryzae

Linka, B., Szakonyi, G., Petkovits, T., Nagy, L. G., Papp, T., Vágvölgyi, C., Benyhe, S. & Ötvös, F., Aug 21 2012, In : Life Sciences. 91, 3-4, p. 115-126 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
17 Citations (Scopus)

What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart

Szûts, V., Ötvös, F., Dézsi, L., Vágvölgyi, C., Szalontai, B., Dobrzynski, H., Boyett, M., Zhang, H., Papp, J. G., Varró, A., Benyhe, S. & Erdélyi, L., Dec 1 2012, In : Acta Biologica Szegediensis. 56, 2, p. 93-107 15 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)
2011

Gridifying the TINKER conformer generator application for gLite grid

Kertész, A., Ötvös, F. & Kacsuk, P., Aug 19 2011, Euro-Par 2010 - Parallel Processing Workshops: HeteroPar, HPPC, HiBB, CoreGrid, UCHPC, HPCF, PROPER, CCPI, VHPC, Revised Selected Papers. p. 185-192 8 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 6586 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)
2007

Anti-calmodulins and tricyclic adjuvants in pain therapy block the TRPV1 channel

Oláh, Z., Jósvay, K., Pecze, L., Letoha, T., Babai, N., Budai, D., Ötvös, F., Szalma, S. & Vizler, C., Jun 20 2007, In : PloS one. 2, 6, e545.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Synthesis and structure-activity relationship of [Nle10] neurokinin A (4-10) analogs with constraint in the backbone and at position six

Ötvös, F., Gembitsky, D. S., Murphy, R. F. & Lovas, S., Jun 1 2007, In : International Journal of Peptide Research and Therapeutics. 13, 1-2, p. 329-336 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2006

Development of a chirality-sensitive flexibility descriptor for 3+3D-QSAR

Dervarics, M., Ötvös, F. & Martinek, T. A., May 1 2006, In : Journal of Chemical Information and Modeling. 46, 3, p. 1431-1438 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2005

Ligand-based prediction of active conformation by 3D-QSAR flexibility descriptors and their application in 3+3D-QSAR models

Martinek, T. A., Ötvös, F., Dervarics, M., Tóth, G. & Fülöp, F., May 5 2005, In : Journal of Medicinal Chemistry. 48, 9, p. 3239-3250 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2003

Conformational analysis of endomorphin-2 by molecular dynamics methods

Leitgeb, B., Ötvös, F. & Tóth, G., Apr 1 2003, In : Biopolymers. 68, 4, p. 497-511 15 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
5 Citations (Scopus)
2002

A specific binding site for a fragment of the B-loop of epidermal growth factor and related peptides

Gembitsky, D. S., Bozsó, Z., O’Flaharty, M., Ötvös, F., Murphy, R. F. & Lovas, S., Jan 1 2002, In : Peptides. 23, 1, p. 97-102 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2001

Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions

Murphy, L. O., Cluck, M. W., Lovas, S., Ötvös, F., Murphy, R. F., Schally, A. V., Permert, J., Larsson, J., Knezetic, J. A. & Adrian, T. E., Apr 6 2001, In : British journal of cancer. 84, 7, p. 926-935 10 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
1999

Coupling difficulty following replacement of Tyr with HOTic during synthesis of an analog of an EGF B-loop fragment

Ötvös, F., Murphy, R. F. & Lovas, S., May 3 1999, In : Journal of Peptide Research. 53, 3, p. 302-307 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Importance of the aromatic residue at position 6 of [Nle10]neurokinin A(4-10) for binding to the NK-2 receptor and receptor activation

Gembitsky, D. S., Murnin, M., Ötvös, F. L., Allen, J., Murphy, R. F. & Lovas, S., Jul 29 1999, In : Journal of Medicinal Chemistry. 42, 15, p. 3004-3007 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Tritiated Kappa receptor antagonist norbinaltorphimine: Synthesis and in vitro binding in three different tissues

Márki, A., Ötvös, F., Tóth, G., Hosztafi, S. & Borsodi, A., Nov 26 1999, In : Life sciences. 66, 1, p. 43-49 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Tritium labeling of 7-isopropoxyisoflavone

Ötvös, F., Tóth, G., Szatmári, I. & Lévai, F., Jan 1 1999, In : Journal of Labelled Compounds and Radiopharmaceuticals. 42, 5, p. 497-503 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

μ-Opioid receptor specific antagonist cyprodime: Characterization by in vitro radioligand and [35S]GTPγS binding assays

Márki, Á., Monory, K., Ötvös, F., Tóth, G., Krassnig, R., Schmidhammer, H., Traynor, J. R., Roques, B. P., Maldonado, R. & Borsodi, A., Oct 27 1999, In : European Journal of Pharmacology. 383, 2, p. 209-214 6 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
1998

Erratum: Synthesis of gonadotropin-releasing hormone III analogs. Structure-antitumor activity relationships (Journal of Medical Chemistry (1997) 40)

Mezo, I., Lovas, S., Palyi, I., Vincze, B., Kalnay, A., Turi, G., Vadasz, Z., Seprodi, J., Idei, M., Toth, G., Gulyas, E., Otvos, F., Mak, M., Horvath, J. E., Teplan, I. & Murphy, R. F., May 21 1998, In : Journal of Medicinal Chemistry. 41, 11, 1 p.

Research output: Contribution to journalComment/debate

Interaction of agonist peptide [3H]Tyr-D-Ala-Phe-Phe-NH2 with μ- opioid receptor in rat brain and CHO-μ/1 cell line

Spetea, M., Ötvös, F., Tóth, G., Nguyen, T. M. D., Schiller, P. W., Vogel, Z. & Borsodi, A., Jun 1 1998, In : Peptides. 19, 6, p. 1091-1098 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

NKA, analogs with conformational constraint

Ötvös, F. L., Gembitsky, D. S., Murphy, R. F. & Lovas, S., Jan 1 1998, In : Biochemical Society transactions. 26, 1, p. S30

Research output: Contribution to journalArticle

1997

Tritium labeling of neuropeptides.

Tóth, G., Lovas, S. & Otvös, F., 1997, In : Methods in molecular biology (Clifton, N.J.). 73, p. 219-230 12 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
1996

13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity

Ötvös, F., Tóth, G., Lovas, S., Simon, C. & Hosztafi, S., Jan 1 1996, In : Helvetica Chimica Acta. 79, 1, p. 133-136 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
1995

Synthesis of high specific activity [15,16‐3H2]buprenorphine

Ötvös, F., Hosztafi, S., Simon, C. & Tóth, G., Jan 1995, In : Journal of Labelled Compounds and Radiopharmaceuticals. 36, 1, p. 79-83 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
1994

Binding characteristics of the novel highly selective delta agonist, [3H]Ile5,6deltorphin II

Nevin, S. T., Kabasakal, L., ötvös, F., Töth, G. & Borsodi, A., Apr 1994, In : Neuropeptides. 26, 4, p. 261-265 5 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)
1993

Tritium Labelling of Naltrindole, a δ‐Receptor‐Selective Opioid Antagonist via 1‐Bromonaltrexone

Tóth, G., Ötvös, F. & Hosztafi, S., Sep 22 1993, In : Helvetica Chimica Acta. 76, 6, p. 2274-2278 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
1992

Characterization of [3H]naltrindole binding to delta opioid receptors in rat brain

Yamamura, M. S., Horvath, R., Toth, G., Otvos, F., Malatynska, E., Knapp, R. J., Porreca, F., Hruby, V. J. & Yamamura, H. I., 1992, In : Life Sciences. 50, 16, p. PL119-PL124

Research output: Contribution to journalArticle

53 Citations (Scopus)

Tritium Labelling of Cyprodime ( = (—)‐17‐(Cyclopropylmethyl)‐4,14‐dimethoxymorphinan‐6‐one), a μ Receptor‐Selective Opioid Antagonist

Ötvös, F., Tóth, G. & Schmidhammer, H., Aug 13 1992, In : Helvetica Chimica Acta. 75, 5, p. 1718-1720 3 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)