• 569 Citations
  • 14 h-Index
20012019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 569 Citations
  • 14 h-Index
  • 58 Article
Filter
Article
2019

Site-Selective Synthesis of 3,17-Diaryl-1,3,5,16-estratetraenes

Jopp, S., Ehlers, P., Frank, E., Mernyák, E., Schneider, G., Wölfling, J., Villinger, A. & Langer, P., Jan 1 2019, In : Synlett. 30, 5, p. 600-604 5 p.

Research output: Contribution to journalArticle

Stereocontrolled synthesis of the four possible 3-methoxy and 3-benzyloxy-16-triazolyl-methyl-estra-17-ol hybrids and their antiproliferative activities

Kiss, A., Wölfling, J., Mernyák, E., Frank, É., Benke, Z., Ashkan Senobar Tahaei, S., Zupkó, I., Mahó, S. & Schneider, G., Dec 2019, In : Steroids. 152, 108500.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Stereoselective synthesis of new type of estradiol hybrid molecules and their antiproliferative activities

Kiss, A., Wölfling, J., Mernyák, E., Frank, É., Gyovai, A., Kulmány, Á., Zupkó, I. & Schneider, G., Aug 2019, In : Steroids. 148, p. 63-72 10 p.

Research output: Contribution to journalArticle

Synthesis, biological evaluation and docking studies of 13-epimeric 10-fluoro- And 10-chloroestra-1,4-dien-3-ones as potential aromatase inhibitors

Jójárt, R., Traj, P., Kovács, É., Horváth, Á., Schneider, G., Szécsi, M., Pál, A., Paragi, G. & Mernyák, E., 2019, In : Molecules. 24, 9, 1783.

Research output: Contribution to journalArticle

Open Access

Synthesis and in vitro antitumor effect of new vindoline-steroid hybrids

Keglevich, A., Zsiros, V., Keglevich, P., Szigetvári, Á., Dékány, M., Szántay, C., Mernyák, E., Wölfling, J. & Hazai, L., Jan 1 2019, In : Current Organic Chemistry. 23, 8, p. 959-967 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1

Herman, B. E., Kiss, A., Wölfling, J., Mernyák, E., Szécsi, M. & Schneider, G., Jan 1 2019, In : Journal of enzyme inhibition and medicinal chemistry. 34, 1, p. 1271-1286 16 p.

Research output: Contribution to journalArticle

Open Access
2018
2 Citations (Scopus)

Antiproliferative properties of newly synthesized 19-nortestosterone analogs without substantial androgenic activity

Gyovai, A., Minorics, R., Kiss, A., Mernyák, E., Schneider, G., Szekeres, A., Kerekes, E., Ocsovszki, I. & Zupkó, I., Jul 27 2018, In : Frontiers in Pharmacology. 9, JUL, 825.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Chemoselective Suzuki-Miyaura reactions of 4-bromo-3-O-triflyl-estrone. Synthesis and atropisomerism of arylated estrones

Jopp, S., Wallaschkowski, T., Ehlers, P., Frank, E., Schneider, G., Wölfling, J., Mernyák, E., Villinger, A. & Langer, P., Jun 7 2018, In : Tetrahedron. 74, 23, p. 2825-2836 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Pd-Catalyzed microwave-assisted synthesis of phosphonated 13α-estrones as potential OATP2B1, 17β-HSD1 and/or STS inhibitors

Jójárt, R., Pécsy, S., Keglevich, G., Szécsi, M., Rigó, R., Ozvegy-Laczka, C., Kecskeméti, G. & Mernyák, E., Nov 14 2018, In : Beilstein Journal of Organic Chemistry. 14, p. 2838-2845 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2 Citations (Scopus)

Synthesis and structure–activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis

Bacsa, I., Herman, B. E., Jójárt, R., Herman, K. S., Wölfling, J., Schneider, G., Varga, M., Tömböly, C., Rižner, T. L., Szécsi, M. & Mernyák, E., Jan 1 2018, In : Journal of enzyme inhibition and medicinal chemistry. 33, 1, p. 1271-1282 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthesis of Artemisinin-Estrogen Hybrids Highly Active against HCMV, P. falciparum, and Cervical and Breast Cancer

Fröhlich, T., Kiss, A., Wölfling, J., Mernyák, E., Kulmány, Á. E., Minorics, R., Zupkó, I., Leidenberger, M., Friedrich, O., Kappes, B., Hahn, F., Marschall, M., Schneider, G. & Tsogoeva, S. B., Nov 8 2018, In : ACS Medicinal Chemistry Letters. 9, 11, p. 1128-1133 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Synthesis of novel 17-triazolyl-androst-5-en-3-ol epimers via Cu(I)-catalyzed azide-alkyne cycloaddition and their inhibitory effect on 17α-hydroxylase/C17,20-lyase

Kiss, A., Herman, B. E., Görbe, T., Mernyák, E., Molnár, B., Wölfling, J., Szécsi, M. & Schneider, G., Jul 1 2018, In : Steroids. 135, p. 79-91 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis of novel C-2- or C-15-labeled BODIPY—estrone conjugates

Bacsa, I., Konc, C., Orosz, A. B., Kecskeméti, G., Rigó, R., zvegy-Laczka, C. & Mernyák, E., 2018, In : Molecules. 23, 4, 821.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

Synthesis and in vitro investigation of potential antiproliferative monosaccharide–D-secoestrone bioconjugates

Bodnár, B., Mernyák, E., Szabó, J., Wölfling, J., Schneider, G., Zupkó, I., Kupihár, Z. & Kovács, L., May 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 9, p. 1938-1942 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Synthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors

Bacsa, I., Jójárt, R., Wölfling, J., Schneider, G., Herman, B. E., Szécsi, M. & Mernyák, E., Jun 30 2017, In : Beilstein Journal of Organic Chemistry. 13, p. 1303-1309 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2016
8 Citations (Scopus)
9 Citations (Scopus)

Stereocontrolled synthesis of the four 16-hydroxymethyl-19-nortestosterone isomers and their antiproliferative activities

Schneider, G., Kiss, A., Mernyák, E., Benke, Z., Wölfling, J., Frank, E., Bózsity, N., Gyovai, A., Minorics, R. & Zupkó, I., Jan 1 2016, In : Steroids. 105, p. 113-120 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Synthesis and biological evaluation of 13α-estrone derivatives as potential antiproliferative agents

Szabó, J., Pataki, Z., Wölfling, J., Schneider, G., Bózsity, N., Minorics, R., Zupkó, I. & Mernyák, E., Sep 1 2016, In : Steroids. 113, p. 14-21 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Synthesis and biological evaluation of triazolyl 13α-estrone-nucleoside bioconjugates

Bodnár, B., Mernyák, E., Wölfling, J., Schneider, G., Herman, B. E., Szécsi, M., Sinka, I., Zupkó, I., Kupihár, Z. & Kovács, L., Sep 2016, In : Molecules. 21, 9, 1212.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthesis and in Vitro antiproliferative evaluation of C-13 epimers of triazolyl-D-secoestrone alcohols: The first potent 13α-D-secoestrone derivative

Szabó, J., Jerkovics, N., Schneider, G., Wölfling, J., Bózsity, N., Minorics, R., Zupkó, I. & Mernyák, E., May 1 2016, In : Molecules. 21, 5, 611.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Synthesis and in vitro pharmacological evaluation of N-[(1-benzyl-1,2,3-triazol-4-yl)methyl]-carboxamides on d-secoestrone scaffolds

Szabó, J., Bacsa, I., Wölfling, J., Schneider, G., Zupkó, I., Varga, M., Herman, B. E., Kalmár, L., Szécsi, M. & Mernyák, E., Jul 3 2016, In : Journal of enzyme inhibition and medicinal chemistry. 31, 4, p. 574-579 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2015

A molecular understanding of d-homoestrone-induced G2/M cell cycle arrest in HeLa human cervical carcinoma cells

Minorics, R., Bózsity, N., Molnár, J., Wölfling, J., Mernyák, E., Schneider, G., Ocsovszki, I. & Zupkó, I., Oct 1 2015, In : Journal of Cellular and Molecular Medicine. 19, 10, p. 2365-2374 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
5 Citations (Scopus)

Synthesis of A-ring halogenated 13α-estrone derivatives as potential 17β-HSD1 inhibitors

Bacsa, I., Jójárt, R., Schneider, G., Wölfling, J., Maróti, P., Herman, B. E., Szécsi, M. & Mernyák, E., Dec 1 2015, In : Steroids. 104, p. 230-236 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Synthesis of methoxycarbonylpyrazolylandrostene derivatives, and their potential inhibitory effect on androgen biosynthesis and cell proliferation

Szabó, N., Iványi, Z., Szécsi, M., Julesz, J., Mernyák, E., Huber, J., Wölfling, J., Minorics, R., Zupkó, I. & Schneider, G., Aug 1 2015, In : Steroids. 98, p. 143-152 10 p., 7762.

Research output: Contribution to journalArticle

10 Citations (Scopus)
7 Citations (Scopus)

Synthesis of trans-16-triazolyl-13α-methyl-17-estradiol diastereomers and the effects of structural modifications on their in vitro antiproliferative activities

Mernyák, E., Kovács, I., Minorics, R., Sere, P., Czégány, D., Sinka, I., Wölfling, J., Schneider, G., Újfaludi, Z., Boros, I., Ocsovszki, I., Varga, M. & Zupkó, I., Jun 1 2015, In : Journal of Steroid Biochemistry and Molecular Biology. 150, p. 123-134 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2014

Syntheses and antiproliferative effects of d-homo- and d-secoestrones

Mernyák, E., Szabó, J., Bacsa, I., Huber, J., Schneider, G., Minorics, R., Bózsity, N., Zupkó, I., Varga, M., Bikádi, Z., Hazai, E. & Wölfling, J., Sep 2014, In : Steroids. 87, p. 128-136 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Synthesis and in vitro antiproliferative evaluation of d-secooxime derivatives of 13β- and 13α-estrone

Mernyák, E., Fiser, G., Szabó, J., Bodnár, B., Schneider, G., Kovács, I., Ocsovszki, I., Zupkó, I. & Wölfling, J., Nov 2014, In : Steroids. 89, p. 47-55 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2013

Cycloaddition of steroidal cyclic nitrones to C=N dipolarophiles: Stereoselective synthesis and antiproliferative effects of oxadiazolidinones in the estrone series

Mernyák, E., Huber, J., Szabó, J., Schneider, G., Hetényi, A., Márk, L., Maász, G., Berényi, Á., Kovács, I., Minorics, R., Zupkó, I. & Wölfling, J., Jan 1 2013, In : Steroids. 78, 10, p. 1021-1028 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Synthesis and investigation of the anticancer effects of estrone-16-oxime ethers in vitro

Berényi, Á., Minorics, R., Iványi, Z., Ocsovszki, I., Ducza, E., Thole, H., Messinger, J., Wölfling, J., Mótyán, G., Mernyák, E., Frank, É., Schneider, G. & Zupkó, I., Jan 1 2013, In : Steroids. 78, 1, p. 69-78 10 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2012
24 Citations (Scopus)
2010

Electrophile-and Lewis acid-induced nitrone formation and 1,3- dipolar cycloaddition reactions in the 13α- and 13β-estrone series

Mernyák, E., Huber, J., Benedek, G., Pfoh, R., Rühl, S., Schneider, G. & Wölfling, J., Sep 27 2010, In : Arkivoc. 2010, 11, p. 101-113 13 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2009

Analysis of nonderivatized steroids by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using C70 fullerene as matrix

Montsko, G., Vaczy, A., Maasz, G., Mernyak, E., Frank, E., Bay, C., Kadar, Z., Ohmacht, R., Wolfling, J. & Mark, L., Aug 17 2009, In : Analytical and bioanalytical chemistry. 395, 3, p. 869-874 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
6 Citations (Scopus)
25 Citations (Scopus)
2008
10 Citations (Scopus)
2006
5 Citations (Scopus)

Selective hydrogenations of steroids catalyzed by heterogenized Ru complexes

Zsigmond, Á., Madácsi, R., Notheisz, F., Mernyák, E. & Joó, F., Apr 1 2006, In : Reaction Kinetics and Catalysis Letters. 87, 2, p. 297-304 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Stereoselective synthesis of some 17β-dihydrooxazinyl steroids, as novel presumed inhibitors of 17α-hydroxylase-C17,20-lyase

Wölfling, J., Oravecz, É. A., Ondré, D., Mernyák, E., Schneider, G., Tóth, I., Szécsi, M. & Julesz, J., Sep 1 2006, In : Steroids. 71, 9, p. 809-816 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Synthesis and stereochemical investigations of novel nitrogen-containing 13α-estrone derivatives

Mernyák, E., Schneider, G., Herbst-Irmer, R., Kubas, M. & Wölfling, J., Jul 1 2006, In : Steroids. 71, 7, p. 558-564 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2005

Efficient heterogeneous racemization of secondary alcohols: Convenient synthesis of 17α-estradiol 3-methyl ether

Zsigmond, Á., Kecskeméti, A., Bogár, K., Notheisz, F. & Mernyák, E., Jul 1 2005, In : Catalysis Communications. 6, 8, p. 520-524 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Stereoselective synthesis of condensed aza-D-homo-estrone derivatives by 1,3-dipolar cycloaddition

Mernyák, E., Benedek, G., Schneider, G. & Wölfling, J., Mar 4 2005, In : Synlett. 4, p. 637-639 3 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2004

Exo-heterociklusos szteroidok szintézise

Translated title of the contribution: Synthesis of exo-heterocyclic steroidsSchneider, G., Wölfling, J., Mernyák, E. & Tóth, I., Mar 1 2004, In : Magyar Kemiai Folyoirat, Kemiai Kozlemenyek. 109-110, 1, p. 40-42 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
38 Citations (Scopus)

The Mitsunobu inversion reaction of sterically hindered 17-hydroxy steroids

Tapolcsányi, P., Wölfling, J., Mernyák, E. & Schneider, G., Sep 1 2004, In : Monatshefte fur Chemie. 135, 9, p. 1129-1136 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)