• 877 Citations
  • 18 h-Index
19962020

Research output per year

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Research Output

  • 877 Citations
  • 18 h-Index
  • 61 Article
  • 1 Comment/debate
  • 1 Review article
2020

Microwave-assisted synthesis, proton dissociation processes, and anticancer evaluation of novel D-ring-fused steroidal 5-amino-1-arylpyrazoles

Mótyán, G., Baji, Á., Marć, M. A., Gopisetty, M. K., Adamecz, D. I., Kiricsi, M., Enyedy, É. A. & Frank, É., Jan 1 2020, In : Applied Sciences (Switzerland). 10, 1, 229.

Research output: Contribution to journalArticle

Open Access
2019

Anti-cancer activity of novel dihydrotestosterone-derived ring a-condensed pyrazoles on androgen non-responsive prostate cancer cell lines

Mótyán, G., Gopisetty, M. K., Kiss-Faludy, R. E., Kulmány, Á., Zupkó, I., Frank, E. & Kiricsi, M., May 1 2019, In : International journal of molecular sciences. 20, 9, 2170.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Microwave-assisted stereoselective heterocyclization to novel ring d-fused arylpyrazolines in the estrone series

Mótyán, G., Molnár, B., Wölfling, J. & Frank, É., Feb 4 2019, In : Molecules. 24, 3, 569.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Site-Selective Synthesis of 3,17-Diaryl-1,3,5,16-estratetraenes

Jopp, S., Ehlers, P., Frank, E., Mernyák, E., Schneider, G., Wölfling, J., Villinger, A. & Langer, P., Jan 1 2019, In : Synlett. 30, 5, p. 600-604 5 p.

Research output: Contribution to journalArticle

Stereocontrolled synthesis of the four possible 3-methoxy and 3-benzyloxy-16-triazolyl-methyl-estra-17-ol hybrids and their antiproliferative activities

Kiss, A., Wölfling, J., Mernyák, E., Frank, E., Benke, Z., Ashkan Senobar Tahaei, S., Zupkó, I., Mahó, S. & Schneider, G., Dec 1 2019, In : Steroids. 152, 108500.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Stereoselective synthesis of new type of estradiol hybrid molecules and their antiproliferative activities

Kiss, A., Wölfling, J., Mernyák, E., Frank, E., Gyovai, A., Kulmány, Á., Zupkó, I. & Schneider, G., Aug 1 2019, In : Steroids. 148, p. 63-72 10 p.

Research output: Contribution to journalArticle

2018

Chemoselective Suzuki-Miyaura reactions of 4-bromo-3-O-triflyl-estrone. Synthesis and atropisomerism of arylated estrones

Jopp, S., Wallaschkowski, T., Ehlers, P., Frank, E., Schneider, G., Wölfling, J., Mernyák, E., Villinger, A. & Langer, P., Jun 7 2018, In : Tetrahedron. 74, 23, p. 2825-2836 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Microwave-assisted synthesis of biologically relevant steroidal 17-exo-pyrazol-5'-ones from a norpregnene precursor by a side-chain elongation/heterocyclization sequence

Mótyán, G., Mérai, L., Kiss, M. A., Schelz, Z., Sinka, I., Zupkó, I. & Frank, E., Oct 8 2018, In : Beilstein Journal of Organic Chemistry. 14, p. 2589-2596 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Synthesis of novel 16-E-(arylidene)-3-methoxy-α-estrones via a palladium catalysed Suzuki-Miyaura reaction

Jopp, S., Liesegang, M., Ehlers, P., Frank, E., Schneider, G., Wölfling, J. & Langer, P., Jan 3 2018, In : Tetrahedron Letters. 59, 1, p. 26-28 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

Corrigendum to “Stereocontrolled synthesis of the four 16-hydroxymethyl-19-nortestosterone isomers and their antiproliferative activities” [Steroids 105 (2016) 113–120](S0039128X15003013)(10.1016/j.steroids.2015.12.003)

Schneider, G., Kiss, A., Mernyák, E., Benke, Z., Wölfling, J., Frank, E., Bózsity, N., Gyovai, A., Minorics, R. & Zupkó, I., Jan 1 2017, In : Steroids. 117, p. 121 1 p.

Research output: Contribution to journalComment/debate

5 Citations (Scopus)

Multicomponent access to androstano-arylpyrimidines under microwave conditions and evaluation of their anti-cancer activity in vitro

Baji, Á., Kiss, T., Wölfling, J., Kovács, D., Igaz, N., Gopisetty, M. K., Kiricsi, M. & Frank, E., Sep 1 2017, In : Journal of Steroid Biochemistry and Molecular Biology. 172, p. 79-88 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Palladium-Catalysed Sonogashira Reactions of 16-(Hydroxymethylidene)-3-methoxy-α-estrone

Jopp, S., Liesegang, M., Ehlers, P., Frank, E., Schneider, G., Wölfling, J., Villinger, A. & Langer, P., Dec 1 2017, In : Synlett. 28, 19, p. 2647-2649 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Synthesis, functionalization and biological activity of arylated derivatives of (+)-estrone

Ivanov, A., Ejaz, S. A., Shah, S. J. A., Ehlers, P., Villinger, A., Frank, E., Schneider, G., Wölfling, J., Rahman, Q., Iqbal, J. & Langer, P., Feb 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 3, p. 949-962 14 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthesis of 16-E-([aryl]idene)-3-methoxy-estrones by a palladium catalysed Mizoroki-Heck reaction

Riebe, S., Jopp, S., Ehlers, P., Frank, E., Schneider, G., Wölfling, J., Villinger, A. & Langer, P., Jan 1 2017, In : Tetrahedron Letters. 58, 29, p. 2801-2803 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2016
9 Citations (Scopus)

Microwave-assisted stereoselective approach to novel steroidal ring D-fused 2-pyrazolines and an evaluation of their cell-growth inhibitory effects in vitro

Mótyán, G., Kovács, F., Wölfling, J., Gyovai, A., Zupkó, I. & Frank, E., Aug 1 2016, In : Steroids. 112, p. 36-46 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
3 Citations (Scopus)

Stereocontrolled synthesis of the four 16-hydroxymethyl-19-nortestosterone isomers and their antiproliferative activities

Schneider, G., Kiss, A., Mernyák, E., Benke, Z., Wölfling, J., Frank, E., Bózsity, N., Gyovai, A., Minorics, R. & Zupkó, I., Jan 1 2016, In : Steroids. 105, p. 113-120 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
8 Citations (Scopus)
2015

A click approach to novel D-ring-substituted 16α-triazolylestrone derivatives and characterization of their antiproliferative properties

Molnár, J., Frank, É., Minorics, R., Kádár, Z., Ocsovszki, I., Schönecker, B., Wölfling, J. & Zupkó, I., Feb 18 2015, In : PloS one. 10, 2, e0118104.

Research output: Contribution to journalArticle

6 Citations (Scopus)
14 Citations (Scopus)
9 Citations (Scopus)
2014

A facile access to novel steroidal 17-2′-(1′,3′,4′) -oxadiazoles, and an evaluation of their cytotoxic activities in vitro

Kovács, D., Mótyán, G., Wölfling, J., Kovács, I., Zupkó, I. & Frank, É., Mar 1 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 5, p. 1265-1268 4 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Anticancer and multidrug resistance-reversal effects of solanidine analogs synthetized from pregnadienolone acetate

Zupkó, I., Molnár, J., Réthy, B., Minorics, R., Frank, É., Wölfling, J., Molnár, J., Ocsovszki, I., Topcu, Z., Bitó, T. & Puskás, L. G., Feb 1 2014, In : Molecules. 19, 2, p. 2061-2076 16 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Regio- and stereoselective access to novel ring-condensed steroidal isoxazolines

Mótyán, G., Kádár, Z., Kovács, D., Wölfling, J. & Frank, É., Sep 2014, In : Steroids. 87, p. 76-85 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
6 Citations (Scopus)
2013
15 Citations (Scopus)

Synthesis and investigation of the anticancer effects of estrone-16-oxime ethers in vitro

Berényi, Á., Minorics, R., Iványi, Z., Ocsovszki, I., Ducza, E., Thole, H., Messinger, J., Wölfling, J., Mótyán, G., Mernyák, E., Frank, É., Schneider, G. & Zupkó, I., Jan 1 2013, In : Steroids. 78, 1, p. 69-78 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
38 Citations (Scopus)
2012
35 Citations (Scopus)

Efficient synthesis of novel A-ring-substituted 1,2,3- triazolylcholestanederivatives via catalytic azide-alkyne cycloaddition

Kádár, Z., Frank, É., Schneider, G., Molnár, J., Zupkó, I., Kóti, J., Schönecker, B. & Wölfling, J., Jan 29 2012, In : Arkivoc. 2012, 3, p. 279-296 18 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Synthesis, characterization and biological evaluation of some novel 17-isoxazoles in the estrone series

Kovács, D., Kádár, Z., Mótyán, G., Schneider, G., Wölfling, J., Zupkó, I. & Frank, É., Sep 1 2012, In : Steroids. 77, 11, p. 1075-1085 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Synthesis, stereochemistry and cytotoxic activity of novel steroidal 16-spiro-1,3,2-dioxaphosphorinanes

Wölfling, J., Kovács-Pénzes, P., Zupkó, I., Schneider, G. & Frank, É., Apr 11 2012, In : Journal of Molecular Structure. 1013, p. 39-44 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2011

Antiproliferative effects of some novel synthetic solanidine analogs on HL-60 human leukemia cells in vitro

Minorics, R., Szekeres, T., Krupitza, G., Saiko, P., Giessrigl, B., Wölfling, J., Frank, É. & Zupkó, I., Jan 1 2011, In : Steroids. 76, 1-2, p. 156-162 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Efficient approach to novel 1α-triazolyl-5α-androstane derivatives as potent antiproliferative agents

Kádár, Z., Baji, Á., Zupkó, I., Bartók, T., Wölfling, J. & Frank, É., Dec 7 2011, In : Organic and Biomolecular Chemistry. 9, 23, p. 8051-8057 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Synthesis and in vitro antiproliferative activity of novel androst-5-ene triazolyl and tetrazolyl derivatives

Kádár, Z., Kovács, D., Frank, É., Schneider, G., Huber, J., Zupkó, I., Bartók, T. & Wölfling, J., Jun 1 2011, In : Molecules. 16, 6, p. 4786-4806 21 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
38 Citations (Scopus)
2010
21 Citations (Scopus)
2009

Analysis of nonderivatized steroids by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using C70 fullerene as matrix

Montsko, G., Vaczy, A., Maasz, G., Mernyak, E., Frank, E., Bay, C., Kadar, Z., Ohmacht, R., Wolfling, J. & Mark, L., Aug 17 2009, In : Analytical and bioanalytical chemistry. 395, 3, p. 869-874 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
6 Citations (Scopus)
15 Citations (Scopus)

Synthesis and conformational preferences of novel steroidal 16-spiro-1, 3, 2-dioxaphosphorinanes

Frank, É., Sipos, L., Wölfling, J. & Schneider, G., Jun 1 2009, In : Letters in Organic Chemistry. 6, 4, p. 340-344 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2008

Synthesis and conformational study of P-heterocyclic androst-5-ene derivatives

Frank, É., Schäfer, B., Mucsi, Z. & Keglevich, G., Jan 31 2008, In : Heteroatom Chemistry. 19, 1, p. 7-14 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2007

6-membered P-heterocycles: Ring-condensed 1,3,2-diheterophosphorinane 2-chalcogenides

Frank, É. & Wöfling, J., Dec 1 2007, In : Current Organic Chemistry. 11, 18, p. 1610-1623 14 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
11 Citations (Scopus)

New steroid-fused P-heterocycles. Part II. Synthesis and conformational study of oxazaphosphorino[16,17-e]estrone derivatives

Frank, É., Kazi, B., Mucsi, Z., Ludányi, K. & Keglevich, G., May 1 2007, In : Steroids. 72, 5, p. 446-458 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
17 Citations (Scopus)
2006

Synthesis of some novel D-ring-fused dioxa- and oxazaphosphorinanes in the estrone series

Frank, É., Kazi, B., Ludányi, K. & Keglevich, G., Feb 13 2006, In : Tetrahedron Letters. 47, 7, p. 1105-1108 4 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)