• 3534 Citations
  • 26 h-Index
1993 …2019

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Article
2019

Glomerular collagen deposition and lipocalin-2 expression are early signs of renal injury in prediabetic obese rats

Bukosza, E. N., Kaucsár, T., Godó, M., Lajtár, E., Tod, P., Koncsos, G., Varga, Z. V., Baranyai, T., Tu, N. M., Schachner, H., Sőti, C., Ferdinandy, P., Giricz, Z., Szénási, G. & Hamar, P., Sep 1 2019, In : International journal of molecular sciences. 20, 17, 4266.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

DAF-21/Hsp90 is required for C. elegans longevity by ensuring DAF-16/FOXO isoform A function

Somogyvári, M., Gecse, E. & Söti, C., Dec 1 2018, In : Scientific Reports. 8, 1, 12048.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hsp90 stabilizes SIRT1 orthologs in mammalian cells and C. elegans

Nguyen, M. T., Somogyvári, M. & Sőti, C., Nov 20 2018, In : International journal of molecular sciences. 19, 11, 3661.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory

Gyurkó, M. D., Csermely, P., Soti, C. & Steták, A., Oct 15 2015, In : Scientific reports. 5, 15084.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Multitarget network strategies to influence memory and forgetting: The Ras/Mapk pathway as a novel option

Dávid Gyurkó, M., Steták, A., Sőti, C. & Csermely, P., May 1 2015, In : Mini-Reviews in Medicinal Chemistry. 15, 8, p. 696-704 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2014

LPS-induced delayed preconditioning is mediated by Hsp90 and involves the heat shock response in mouse kidney

Kaucsár, T., Bodor, C., Godó, M., Szalay, C., Révész, C., Németh, Z., Mózes, M., Szénási, G., Rosivall, L., Soti, C. & Hamar, P., Mar 19 2014, In : PloS one. 9, 3, e92004.

Research output: Contribution to journalArticle

6 Citations (Scopus)

System level mechanisms of adaptation, learning, memory formation and evolvability: The role of chaperone and other networks

Gyurkó, D. M., Soti, C., Steták, A. & Csermely, P., Jan 1 2014, In : Current Protein and Peptide Science. 15, 3, p. 171-188 18 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2012

A role for SKN-1/Nrf in pathogen resistance and immunosenescence in caenorhabditis elegans

Papp, D., Csermely, P. & Soti, C., Apr 2012, In : PLoS Pathogens. 8, 4, e1002673.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Misfolded proteins inhibit proliferation and promote stress-induced death in SV40-transformed mammalian cells

Arslan, M. A., Chikina, M., Csermely, P. & Soti, C., Feb 1 2012, In : FASEB Journal. 26, 2, p. 766-777 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

RNA interference links oxidative stress to the inhibition of heat stress adaptation

Spiró, Z., Arslan, M. A., Somogyvári, M., Nguyen, M. T., Smolders, A., Dancsó, B., Németh, N., Elek, Z., Braeckman, B. P., Csermely, P. & Soti, C., Sep 15 2012, In : Antioxidants and Redox Signaling. 17, 6, p. 890-901 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2011

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M., Piper, M. D., Hoddinott, M., Sutphin, G. L., Leko, V., McElwee, J. J., Vazquez-Manrique, R. P., Orfila, A. M., Ackerman, D., Au, C., Vinti, G., Riesen, M., Howard, K., Neri, C., Bedalov, A., Kaeberlein, M. & 3 others, Söti, C., Partridge, L. & Gems, D., Sep 22 2011, In : Nature. 477, 7365, p. 482-485 4 p.

Research output: Contribution to journalArticle

439 Citations (Scopus)

Low ambient temperature reveals distinct mechanisms for MDMA-induced serotonergic toxicity and astroglial Hsp27 heat shock response in rat brain

Ádori, C., Andó, R. D., Balázsa, T., Sti, C., Vas, S., Palkovits, M., Kovács, G. G. & Bagdy, G., Oct 1 2011, In : Neurochemistry international. 59, 5, p. 695-705 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2009

Ageing as a price of cooperation and complexity: Self-organization of complex systems causes the gradual deterioration of constituent networks

Kiss, H. J. M., Mihalik, Á., Nánási, T., Ory, B., Spiró, Z., Soti, C. & Csermely, P., Jul 31 2009, In : BioEssays. 31, 6, p. 651-664 14 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2008
37 Citations (Scopus)

Resveratrol induces the heat-shock response and protects human cells from severe heat stress

Putics, Á., Végh, E. M., Csermely, P. & Soti, C., Jan 1 2008, In : Antioxidants and Redox Signaling. 10, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Zinc, metallothioneins, longevity: Effect of zinc supplementation on antioxidant response: A zincage study

Mocchegiani, E., Malavolta, M., Giacconi, R., Cipriano, C., Costarelli, L., Muti, E., Tesei, S., Giuli, C., Papa, R., Marcellini, F., Mariani, E., Rink, L., Herbein, G., Fulop, T., Monti, D., Jajte, J., Dedoussis, G., Gonos, E. S., Buerkle, A., Friguet, B. & 7 others, Mecocci, P., Colasanti, M., Soti, C., Mazzatti, D., Blasco, M., Aspinall, R. & Pawelec, G., Apr 1 2008, In : Rejuvenation Research. 11, 2, p. 419-423 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Zinc supplementation boosts the stress response in the elderly: Hsp70 status is linked to zinc availability in peripheral lymphocytes

Putics, Á., Vödrös, D., Malavolta, M., Mocchegiani, E., Csermely, P. & Soti, C., May 1 2008, In : Experimental gerontology. 43, 5, p. 452-461 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2007

Chaperones as parts of cellular networks.

Csermely, P., Söti, C. & Blatch, G. L., 2007, In : Advances in Experimental Medicine and Biology. 594, p. 55-63 9 p.

Research output: Contribution to journalArticle

Expressed as the sole Hsp90 of yeast, the α and β isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90β generates sensitivity to the Hsp90 inhibitor radicicol

Millson, S. H., Truman, A. W., Rácz, A., Hu, B., Panaretou, B., Nuttall, J., Mollapour, M., Söti, C. & Piper, P. W., Sep 1 2007, In : FEBS Journal. 274, 17, p. 4453-4463 11 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)
2006

Cellular networks and the aging process

Csermely, P. & Soti, C., Apr 1 2006, In : Archives of Physiology and Biochemistry. 112, 2, p. 60-64 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2005

Modelling the actions of chaperones and their role in ageing

Proctor, C. J., Soti, C., Boys, R. J., Gillespie, C. S., Shanley, D. P., Wilkinson, D. J. & Kirkwood, T. B. L., Jan 1 2005, In : Mechanisms of Ageing and Development. 126, 1, p. 119-131 13 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)
2004

Inhibition of Hsp90: A new strategy for inhibiting protein kinases

Sreedhar, A. S., Soti, C. & Csermely, P., Mar 11 2004, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1697, 1-2, p. 233-242 10 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)
2003

Aging and molecular chaperones

Soti, C. & Csermely, P., Oct 2003, In : Experimental gerontology. 38, 10, p. 1037-1040 4 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)
60 Citations (Scopus)

Molecular chaperones, evolution and medicine

Csermely, P., Soti, C., Kalmar, E., Papp, E., Pato, B., Vermes, A. & Sreedhar, A. S., Dec 29 2003, In : Journal of Molecular Structure: THEOCHEM. 666-667, p. 373-380 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Molecular chaperones, stress proteins and redox homeostasis

Papp, E., Nardai, G., Soti, C. & Csermely, P., Jan 1 2003, In : BioFactors. 17, 1-4, p. 249-257 9 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

The Heat Shock Protein 90-Targeting Drug Cisplatin Selectively Inhibits Steroid Receptor Activation

Rosenhagen, M. C., Sõti, C., Schmidt, U., Wochnik, G. M., Hartl, F. U., Holsboer, F., Young, J. C. & Rein, T., Oct 1 2003, In : Molecular Endocrinology. 17, 10, p. 1991-2001 11 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
2002
181 Citations (Scopus)

Chaperone function and chaperone overload in the aged. A preliminary analysis

Nardai, G. Á., Csermely, P. & Söti, C., Oct 1 2002, In : Experimental gerontology. 37, 10-11, p. 1257-1262 6 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
2000

Interaction of the human DnaJ homologue, HSJ1b with the 90 kDa heat shock protein, Hsp90

Schnaider, T., Soti, C., Cheetham, M. E., Miyata, Y., Yahara, I. & Csermely, P., Aug 11 2000, In : Life Sciences. 67, 12, p. 1455-1465 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
1998

Characterization of the nucleotide binding properties of the 90 kDa heat shock protein (Hsp90)

Sőti, C. & Csermely, P., Oct 1998, In : Journal of Biosciences. 23, 4, p. 347-352 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Interaction of vanadate oligomers and permolybdate with the 90-kDa heat-shock protein, Hsp90

Söti, C., Radics, L., Yahara, I. & Csermely, P., Aug 1 1998, In : European Journal of Biochemistry. 255, 3, p. 611-617 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Molecular chaperones in the etiology and therapy of cancer

Soti, C. & Csermely, P., Jan 1 1998, In : Pathology and Oncology Research. 4, 4, p. 316-321 6 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
1997

Binding affinity of proteins to hsp90 correlates with both hydrophobicity and positive charges. A surface plasmon resonance study

Csermely, P., Miyata, Y., Soti, C. & Yahara, I., Jun 20 1997, In : Life Sciences. 61, 4, p. 411-418 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
1996

Characterization of the 90 kDa heat shock protein (HSP90)-associated ATP/GTPase

Nardai, G., Schnaider, T., Söti, C., Ryan, M. T., Hoj, P. B., Somogyi, J. & Csermely, P., Apr 1996, In : Journal of Biosciences. 21, 2, p. 179-190 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
1993

ATP induces a conformational change of the 90-kDa heat shock protein (hsp90)

Csermely, P., Kajtar, J., Hollosi, M., Jalsovszky, G., Holly, S., Kahn, C. R., Gergely, P., Soti, C., Mihaly, K. & Somogyi, J., Jan 1 1993, In : Journal of Biological Chemistry. 268, 3, p. 1901-1907 7 p.

Research output: Contribution to journalArticle

127 Citations (Scopus)