• 3509 Citations
  • 30 h-Index
19972019

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Article
2019

Mutated SUCLG1 causes mislocalization of SUCLG2 protein, morphological alterations of mitochondria and an early-onset severe neurometabolic disorder

Chinopoulos, C., Batzios, S., van den Heuvel, L. P., Rodenburg, R., Smeets, R., Waterham, H. R., Turkenburg, M., Ruiter, J. P., Wanders, R. J. A., Doczi, J., Horvath, G., Dobolyi, A., Vargiami, E., Wevers, R. A. & Zafeiriou, D., Jan 2019, In : Molecular Genetics and Metabolism. 126, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The Effect of 2-Ketobutyrate on Mitochondrial Substrate-Level Phosphorylation

Bui, D., Ravasz, D. & Chinopoulos, C., Oct 1 2019, In : Neurochemical research. 44, 10, p. 2301-2306 6 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma

Mukherjee, P., Augur, Z. M., Li, M., Hill, C., Greenwood, B., Domin, M. A., Kondakci, G., Narain, N. R., Kiebish, M. A., Bronson, R. T., Arismendi-Morillo, G., Chinopoulos, C. & Seyfried, T. N., Dec 1 2019, In : Communications Biology. 2, 1, 200.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2018

Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder

Chinopoulos, C., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost

Salin, K., Villasevil, E. M., Anderson, G. J., Auer, S. K., Selman, C., Hartley, R. C., Mullen, W., Chinopoulos, C. & Metcalfe, N. B., Sep 2018, In : Functional Ecology. 32, 9, p. 2149-2157 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Functional cyclophilin D moderates platelet adhesion, but enhances the lytic resistance of fibrin

Varjú, I., Farkas, V. J., Kőhidai, L., Szabó, L., Farkas, Á. Z., Polgár, L., Chinopoulos, C. & Kolev, K., Dec 1 2018, In : Scientific Reports. 8, 1, 5366.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Mycoplasma infection and hypoxia initiate succinate accumulation and release in the VM-M3 cancer cells

Flores, R. E., Brown, A. K., Taus, L., Khoury, J., Glover, F., Kami, K., Sarangarajan, R., Walshe, T. E., Narain, N. R., Kiebish, M. A., Shelton, L. M., Chinopoulos, C. & Seyfried, T. N., Sep 2018, In : Biochimica et Biophysica Acta - Bioenergetics. 1859, 9, p. 975-983 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Perturbation of the yeast mitochondrial lipidome and associated membrane proteins following heterologous expression of Artemia-ANT

Chen, E., Kiebish, M. A., McDaniel, J., Niedzwiecka, K., Kucharczyk, R., Ravasz, D., Gao, F., Narain, N. R., Sarangarajan, R., Seyfried, T. N., Adam-Vizi, V. & Chinopoulos, C., Dec 1 2018, In : Scientific reports. 8, 1, 5915.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The RCR and ATP/O Indices Can Give Contradictory Messages about Mitochondrial Efficiency

Salin, K., Villasevil, E. M., Anderson, G. J., Selman, C., Chinopoulos, C. & Metcalfe, N. B., Sep 1 2018, In : Integrative and Comparative Biology. 58, 3, p. 486-494 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

ATP synthase complex and the mitochondrial permeability transition pore: Poles of attraction

Chinopoulos, C., Jul 2017, In : EMBO Reports. 18, 7, p. 1041-1042 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Catabolism of GABA, succinic semialdehyde or gamma-hydroxybutyrate through the GABA shunt impair mitochondrial substrate-level phosphorylation

Ravasz, D., Kacso, G., Fodor, V., Horvath, K., Adam-Vizi, V. & Chinopoulos, C., Oct 2017, In : Neurochemistry international. 109, p. 41-53 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Divalent cation chelators citrate and EDTA unmask an intrinsic uncoupling pathway in isolated mitochondria

Starkov, A. A., Chinopoulos, C., Starkova, N. N., Konrad, C., Kiss, G., Stepanova, A. & Popov, V. N., Feb 1 2017, In : Journal of Bioenergetics and Biomembranes. 49, 1, p. 3-11 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage

Németh, B., Doczi, J., Csete, D., Kacso, G., Ravasz, D., Adams, D., Kiss, G., Nagy, A. M., Horvath, G., Tretter, L., Mócsai, A., Csépányi-Kömi, R., Iordanov, I., Adam-Vizi, V. & Chinopoulos, C., Jan 1 2016, In : FASEB Journal. 30, 1, p. 286-300 15 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Alterations in voltage-sensing of the mitochondrial permeability transition pore in ANT1-deficient cells

Doczi, J., Törőcsik, B., Echaniz-Laguna, A., De Camaret, B. M., Starkov, A., Starkova, N., Gál, A., Molńr, M. J., Kawamata, H., Manfredi, G., Ádám-Vizi, V. & Chinopoulos, C., May 25 2016, In : Scientific Reports. 6, 26700.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Cyclophilin D regulates lifespan and protein expression of aging markers in the brain of mice

Vereczki, V., Mansour, J., Pour-Ghaz, I., Bodnár, I., Pinter, O., Zelena, D., Oszwald, E., Ádám-Vizi, V. & Chinopoulos, C., Jun 13 2016, (Accepted/In press) In : Mitochondrion.

Research output: Contribution to journalArticle

1 Citation (Scopus)
101 Citations (Scopus)

The total and mitochondrial lipidome of Artemia franciscana encysted embryos

Chen, E., Kiebish, M. A., McDaniel, J., Gao, F., Narain, N. R., Sarangarajan, R., Kacso, G., Ravasz, D., Seyfried, T. N., Adam-Vizi, V. & Chinopoulos, C., Nov 1 2016, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1861, 11, p. 1727-1735 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2015

Cyclophilin D disruption attenuates lipopolysaccharide-induced inflammatory response in primary mouse macrophages

Priber, J., Fonai, F., Jakus, P. B., Racz, B., Chinopoulos, C., Tretter, L., Gallyas, F., Sumegi, B. & Veres, B., Jan 23 2015, In : Biochemistry and Cell Biology. 93, 3, p. 241-250 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Exclusive neuronal expression of SUCLA2 in the human brain

Dobolyi, A., Ostergaard, E., Bagó, A. G., Dóczi, T., Palkovits, M., Gál, A., Molnár, M. J., Adam-Vizi, V. & Chinopoulos, C., Jan 1 2015, In : Brain Structure and Function. 220, 1, p. 135-151 17 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2014
5 Citations (Scopus)

Mitochondrial diaphorases as NAD+ donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition

Kiss, G., Konrad, C., Pour-Ghaz, I., Mansour, J. J., Németh, B., Starkov, A. A., Adam-Vizi, V. & Chinopoulos, C., Apr 2014, In : FASEB Journal. 28, 4, p. 1682-1697 16 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2013

The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation

Kiss, G., Konrad, C., Doczi, J., Starkov, A. A., Kawamata, H., Manfredi, G., Zhang, S. F., Gibson, G. E., Beal, M. F., Adam-Vizi, V. & Chinopoulos, C., Jun 1 2013, In : FASEB Journal. 27, 6, p. 2393-2406 14 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

The Suppressor of AAC2 Lethality SAL1 Modulates Sensitivity of Heterologously Expressed Artemia ADP/ATP Carrier to Bongkrekate in Yeast

Wysocka-Kapcinska, M., Torocsik, B., Turiak, L., Tsaprailis, G., David, C. L., Hunt, A. M., Vekey, K., Adam-Vizi, V., Kucharczyk, R. & Chinopoulos, C., Sep 20 2013, In : PloS one. 8, 9, e74187.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2012
8 Citations (Scopus)

Quantitative measurement of mitochondrial membrane potential in cultured cells: Calcium-induced de- and hyperpolarization of neuronal mitochondria

Gerencser, A. A., Chinopoulos, C., Birket, M. J., Jastroch, M., Vitelli, C., Nicholls, D. G. & Brand, M. D., Jun 1 2012, In : Journal of Physiology. 590, 12, p. 2845-2871 27 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)
2011
9 Citations (Scopus)

adPEO mutations in ANT1 impair ADP-ATP translocation in muscle mitochondria

Kawamata, H., Tiranti, V., Magrané, J., Chinopoulos, C. & Manfredi, G., Aug 1 2011, In : Human molecular genetics. 20, 15, p. 2964-2974 11 p., ddr200.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Complex contribution of cyclophilin D to Ca2+-induced permeability transition in brain mitochondria, with relation to the bioenergetic state

Doczi, J., Turiák, L., Vajda, S., Mándi, M., Töröcsik, B., Gerencser, A. A., Kiss, G., Konràd, C., Adam-Vizi, V. & Chinopoulos, C., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6345-6353 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels

Chinopoulos, C., Konràd, C., Kiss, G., Metelkin, E., Töröcsik, B., Zhang, S. F. & Starkov, A. A., Apr 1 2011, In : FEBS Journal. 278, 7, p. 1112-1125 14 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2010

A kinetic assay of mitochondrial ADP-ATP exchange rate in permeabilized cells

Kawamata, H., Starkov, A. A., Manfredi, G. & Chinopoulos, C., Dec 1 2010, In : Analytical Biochemistry. 407, 1, p. 52-57 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Forward operation of adenine nucleotide translocase during F 0F1-ATPase reversal: Critical role of matrix substrate-level phosphorylation

Chinopoulos, C., Gerencser, A. A., Mandi, M., Mathe, K., Töröcsik, B., Doczi, J., Turiak, L., Kiss, G., Konràd, C., Vajda, S., Vereczki, V., Oh, R. J. & Adam-Vizi, V., Jul 1 2010, In : FASEB Journal. 24, 7, p. 2405-2416 12 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
2009

A novel kinetic assay of mitochondrial ATP-ADP exchange rate mediated by the ANT

Chinopoulos, C., Vajda, S., Csanády, L., Mándi, M., Mathe, K. & Adam-Vizi, V., Jan 1 2009, In : Biophysical journal. 96, 6, p. 2490-2504 15 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

A re-evaluation of the role of matrix acidification in uncoupler-induced Ca2+ release from mitochondria

Vajda, S., Mándi, M., Konràd, C., Kiss, G., Ambrus, A., Adam-Vizi, V. & Chinopoulos, C., May 1 2009, In : FEBS Journal. 276, 10, p. 2713-2724 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Modeling of ATP-ADP steady-state exchange rate mediated by the adenine nucleotide translocase in isolated mitochondria

Metelkin, E., Demin, O., Kovács, Z. & Chinopoulos, C., Dec 1 2009, In : FEBS Journal. 276, 23, p. 6942-6955 14 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2007
9 Citations (Scopus)
2005

Diacylglycerols activate mitochondrial cationic channel(s) and release sequestered Ca2+

Chinopoulos, C., Starkov, A. A., Grigoriev, S., Dejean, L. M., Kinnally, K. W., Liu, X., Ambudkar, I. S. & Fiskum, G., Aug 1 2005, In : Journal of Bioenergetics and Biomembranes. 37, 4, p. 237-247 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2004

Inhibition of glutamate-induced delayed calcium deregulation by 2-APB and La3+ in cultured cortical neurones

Chinopoulos, C., Gerencser, A. A., Doczi, J., Fiskum, G. & Adam-Vizi, V., Oct 1 2004, In : Journal of neurochemistry. 91, 2, p. 471-483 13 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury

Starkov, A. A., Chinopoulos, C. & Fiskum, G., Jan 1 2004, In : Cell Calcium. 36, 3-4, p. 257-264 8 p.

Research output: Contribution to journalArticle

225 Citations (Scopus)

Mitochondrial α-ketoglutarate dehydrogenase complex generates reactive oxygen species

Starkov, A. A., Fiskum, G., Chinopoulos, C., Lorenzo, B. J., Browne, S. E., Patel, M. S. & Beal, M. F., Sep 8 2004, In : Journal of Neuroscience. 24, 36, p. 7779-7788 10 p.

Research output: Contribution to journalArticle

476 Citations (Scopus)

Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress

Fiskum, G., Rosenthal, R. E., Vereczki, V., Martin, E., Hoffman, G. E., Chinopoulos, C. & Kowaltowski, A., Aug 1 2004, In : Journal of Bioenergetics and Biomembranes. 36, 4 SPEC.ISS., p. 347-352 6 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)
2003

Characterization of the N-acetylaspartate biosynthetic enzyme from rat brain

Madhavarao, C. N., Chinopoulos, C., Chandrasekaran, K. & Namboodiri, M. A. A., Aug 1 2003, In : Journal of neurochemistry. 86, 4, p. 824-835 12 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Cyclosporin A-insensitive permeability transition in brain mitochondria. Inhibition by 2-aminoethoxydiphenyl borate

Chinopoulos, C., Starkov, A. A. & Fiskum, G., Jul 25 2003, In : Journal of Biological Chemistry. 278, 30, p. 27382-27389 8 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)

Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's disease

Fiskum, G., Starkov, A., Polster, B. M. & Chinopoulos, C., Jan 1 2003, In : Annals of the New York Academy of Sciences. 991, p. 111-119 9 p.

Research output: Contribution to journalArticle

201 Citations (Scopus)

Neuroprotective effects of bilobalide, a component of ginkgo biloba extract (EGb 761®) in global brain ischemia and in excitotoxicity-induced neuronal death

Chandrasekaran, K., Mehrabian, Z., Spinnewyn, B., Chinopoulos, C., Drieu, K. & Fiskum, G., Jun 1 2003, In : Pharmacopsychiatry. 36, SUPPL. 1, p. S89-S94

Research output: Contribution to journalArticle

87 Citations (Scopus)
2002

Bilobalide, a component of the Ginkgo biloba extract (EGb 761), protects against neuronal death in global brain ischemia and in glutamate-induced excitotoxicity.

Chandrasekaran, K., Mehrabian, Z., Spinnewyn, B., Chinopoulos, C., Drieu, K. & Fiskum, G., Sep 2002, In : Cellular and molecular biology (Noisy-le-Grand, France). 48, 6, p. 663-669 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
14 Citations (Scopus)
2001
60 Citations (Scopus)
2000
68 Citations (Scopus)
10 Citations (Scopus)