• 3017 Citations
  • 26 h-Index
20002020

Research output per year

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Research Output

  • 3017 Citations
  • 26 h-Index
  • 37 Article
  • 5 Review article
  • 1 Chapter
  • 1 Short survey
2000
26 Citations (Scopus)
2001
44 Citations (Scopus)

Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells

Özvegy, C., Litman, T., Szakács, G., Nagy, Z., Bates, S., Váradi, A. & Sarkadi, B., Jan 1 2001, In : Biochemical and Biophysical Research Communications. 285, 1, p. 111-117 7 p.

Research output: Contribution to journalArticle

248 Citations (Scopus)
41 Citations (Scopus)
2002
181 Citations (Scopus)
2003

Application of a human multidrug transporter (ABCG2) variant as selectable marker in gene transfer to progenitor cells

Ujhelly, O., Özvegy, C., Várady, G., Cervenak, J., Homolya, L., Grez, M., Scheffer, G., Roos, D., Bates, S. E., Váradi, A., Sarkadi, B. & Német, K., Mar 1 2003, In : Human Gene Therapy. 14, 4, p. 403-412 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2004

ABCG2 - A transporter for all seasons

Sarkadi, B., Özvegy-Laczka, C., Német, K. & Váradi, A., Jun 1 2004, In : FEBS letters. 567, 1, p. 116-120 5 p.

Research output: Contribution to journalArticle

225 Citations (Scopus)

Functional expression and characterization of the human ABCG1 and ABCG4 proteins: Indications for heterodimerization

Cserepes, J., Szentpétery, Z., Seres, L., Özvegy-Laczka, C., Langmann, T., Schmitz, G., Glavinas, H., Klein, I., Homolya, L., Váradi, A., Sarkadi, B. & Elkind, N. B., Jul 30 2004, In : Biochemical and biophysical research communications. 320, 3, p. 860-867 8 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter

Özvegy-Laczka, C., Hegedus, T., Várady, G., Ujhelly, O., Schuetz, J. D., Váradi, A., Kéri, G., Orfi, L., Német, K. & Sarkadi, B., Jun 1 2004, In : Molecular pharmacology. 65, 6, p. 1485-1495 11 p.

Research output: Contribution to journalArticle

279 Citations (Scopus)
2005

Function-dependent conformational changes of the ABCG2 multidrug transporter modify its interaction with a monoclonal antibody on the cell surface

Özvegy-Laczka, C., Várady, G., Köblös, G., Ujhelly, O., Cervenak, J., Schuetz, J. D., Sorrentino, B. P., Koomen, G. J., Váradi, A., Német, K. & Sarkadi, B., Feb 11 2005, In : Journal of Biological Chemistry. 280, 6, p. 4219-4227 9 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
195 Citations (Scopus)
66 Citations (Scopus)

Single nucleotide polymorphisms modify the transporter activity of ABCG2

Morisaki, K., Robey, R. W., Özvegy-Laczka, C., Honjo, Y., Polgar, O., Steadman, K., Sarkadi, B. & Bates, S. E., Aug 1 2005, In : Cancer Chemotherapy And Pharmacology. 56, 2, p. 161-172 12 p.

Research output: Contribution to journalArticle

173 Citations (Scopus)

Tyrosine kinase inhibitor resistance in cancer: Role of ABC multidrug transporters

Özvegy-Laczka, C., Cserepes, J., Elkind, N. B. & Sarkadi, B., Jan 1 2005, In : Drug Resistance Updates. 8, 1-2, p. 15-26 12 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)
2006

Mutational studies of G553 in TM5 of ABCG2: A residue potentially involved in dimerization

Polgar, O., Ozvegy-Laczka, C., Robey, R. W., Morisaki, K., Okada, M., Tamaki, A., Koblos, G., Elkind, N. B., Ward, Y., Dean, M., Sarkadi, B. & Bates, S. E., Apr 25 2006, In : Biochemistry. 45, 16, p. 5251-5260 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
136 Citations (Scopus)
34 Citations (Scopus)
2007
93 Citations (Scopus)
2008
16 Citations (Scopus)

Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter

Özvegy-Laczka, C., Laczko, R., Hegedus, C., Litman, T., Várady, G., Goda, K., Hegedus, T., Dokholyan, N. V., Sorrentino, B. P., Váradi, A. & Sarkadi, B., Sep 19 2008, In : Journal of Biological Chemistry. 283, 38, p. 26059-26070 12 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
329 Citations (Scopus)
2009

Arginine 383 is a crucial residue in ABCG2 biogenesis

Polgar, O., Ediriwickrema, L. S., Robey, R. W., Sharma, A., Hegde, R. S., Li, Y., Xia, D., Ward, Y., Dean, M., Ozvegy-Laczka, C., Sarkadi, B. & Bates, S. E., Jul 1 2009, In : Biochimica et Biophysica Acta - Biomembranes. 1788, 7, p. 1434-1443 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
36 Citations (Scopus)
154 Citations (Scopus)
2011
85 Citations (Scopus)
2012

Antibody binding shift assay for rapid screening of drug interactions with the human ABCG2 multidrug transporter

Telbisz, Á., Hegedüs, C., Özvegy-Laczka, C., Goda, K., Várady, G., Takáts, Z., Szabó, E., Sorrentino, B. P., Váradi, A. & Sarkadi, B., Jan 23 2012, In : European Journal of Pharmaceutical Sciences. 45, 1-2, p. 101-109 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
45 Citations (Scopus)

PI3-kinase and mTOR inhibitors differently modulate the function of the ABCG2 multidrug transporter

Hegedüs, C., Truta-Feles, K., Antalffy, G., Brózik, A., Kasza, I., Német, K., Orbán, T. I., Özvegy-Laczka, C., Váradi, A. & Sarkadi, B., Apr 20 2012, In : Biochemical and biophysical research communications. 420, 4, p. 869-874 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2013

ABCG2 is not able to catalyze glutathione efflux and does not contribute to GSH-dependent collateral sensitivity

Gauthier, C., Ozvegy-Laczka, C., Szakacs, G., Sarkadi, B. & Pietro, A. D., 2013, In : Frontiers in Pharmacology. 4 NOV, Article 138.

Research output: Contribution to journalArticle

9 Citations (Scopus)
20 Citations (Scopus)
28 Citations (Scopus)

Structure-activity relationships of chromone derivatives toward the mechanism of interaction with and inhibition of breast cancer resistance protein ABCG2

Winter, E., Lecerf-Schmidt, F., Gozzi, G., Peres, B., Lightbody, M., Gauthier, C., Ozvegy-Laczka, C., Szakacs, G., Sarkadi, B., Creczynski-Pasa, T. B., Boumendjel, A. & Di Pietro, A., Dec 27 2013, In : Journal of Medicinal Chemistry. 56, 24, p. 9849-9860 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2014
24 Citations (Scopus)
2015

Functional expression of the 11 human Organic Anion Transporting Polypeptides in insect cells reveals that sodium fluorescein is a general OATP substrate

Patik, I., Kovacsics, D., Német, O., Gera, M., Várady, G., Stieger, B., Hagenbuch, B., Szakács, G. & Özvegy-Laczka, C., Dec 15 2015, In : Biochemical Pharmacology. 98, 4, p. 649-658 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Lipid Regulation of the ABCB1 and ABCG2 Multidrug Transporters

Hegedüs, C., Telbisz, Á., Hegedus, T., Sarkadi, B. & Özvegy-Laczka, C., Jan 1 2015, Advances in Cancer Research. Academic Press Inc., p. 97-137 41 p. (Advances in Cancer Research; vol. 125).

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Citations (Scopus)
14 Citations (Scopus)
2017

The importance of steroid uptake and intracrine action in endometrial and ovarian cancers

Rižner, T. L., Thalhammer, T. & özvegy-Laczka, C., 2017, In : Frontiers in Pharmacology. 8, JUN, 346.

Research output: Contribution to journalReview article

15 Citations (Scopus)

The role of organic anion transporting polypeptides in drug absorption, distribution, excretion and drug-drug interactions

Kovacsics, D., Patik, I. & Özvegy-Laczka, C., Apr 3 2017, In : Expert Opinion on Drug Metabolism and Toxicology. 13, 4, p. 409-424 16 p.

Research output: Contribution to journalReview article

25 Citations (Scopus)
2018

Identification of novel cell-impermeant fluorescent substrates for testing the function and drug interaction of Organic Anion-Transporting Polypeptides, OATP1B1/1B3 and 2B1

Patik, I., Székely, V., Német, O., Szepesi, Á., Kucsma, N., Várady, G., Szakács, G., Bakos, E. & Özvegy-Laczka, C., Dec 1 2018, In : Scientific Reports. 8, 1, 2630.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Influence of OATPs on Hepatic Disposition of Erlotinib Measured With Positron Emission Tomography

Bauer, M., Matsuda, A., Wulkersdorfer, B., Philippe, C., Traxl, A., Özvegy-Laczka, C., Stanek, J., Nics, L., Klebermass, E. M., Poschner, S., Jäger, W., Patik, I., Bakos, É., Szakács, G., Wadsak, W., Hacker, M., Zeitlinger, M. & Langer, O., Jul 2018, In : Clinical Pharmacology and Therapeutics. 104, 1, p. 139-147 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Pd-Catalyzed microwave-assisted synthesis of phosphonated 13α-estrones as potential OATP2B1, 17β-HSD1 and/or STS inhibitors

Jójárt, R., Pécsy, S., Keglevich, G., Szécsi, M., Rigó, R., Ozvegy-Laczka, C., Kecskeméti, G. & Mernyák, E., Nov 14 2018, In : Beilstein Journal of Organic Chemistry. 14, p. 2838-2845 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2019

Identification of anticancer OATP2B1 substrates by an in vitro triple-fluorescence-based cytotoxicity screen

Windt, T., Tóth, S., Patik, I., Sessler, J., Kucsma, N., Szepesi, Á., Zdrazil, B., Özvegy-Laczka, C. & Szakács, G., Jan 1 2019, In : Archives of Toxicology.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2020

A novel fluorescence-based functional assay for human OATP1A2 and OATP1C1 identifies interaction between third-generation P-gp inhibitors and OATP1A2

Bakos, É., Német, O., Patik, I., Kucsma, N., Várady, G., Szakács, G. & Özvegy-Laczka, C., Jun 1 2020, In : FEBS Journal. 287, 12, p. 2468-2485 18 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Fluorescent probes for the dual investigation of MRP2 and OATP1B1 function and drug interactions

Székely, V., Patik, I., Ungvári, O., Telbisz, Á., Szakács, G., Bakos, É. & Özvegy-Laczka, C., Aug 1 2020, In : European Journal of Pharmaceutical Sciences. 151, 105395.

Research output: Contribution to journalArticle

Open Access