• 13983 Citations
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1971 …2020

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Article
2020

Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter

Zámbó, B., Mózner, O., Bartos, Z., Török, G., Várady, G., Telbisz, Á., Homolya, L., Orbán, T. I. & Sarkadi, B., Jan 1 2020, In : Cellular and Molecular Life Sciences. 77, 2, p. 365-378 14 p.

Research output: Contribution to journalArticle

Open Access

Glutaminases as a novel target for SDHB-associated pheochromocytomas/paragangliomas

Sarkadi, B., Meszaros, K., Krencz, I., Canu, L., Krokker, L., Zakarias, S., Barna, G., Sebestyen, A., Papay, J., Hujber, Z., Butz, H., Darvasi, O., Igaz, P., Doczi, J., Luconi, M., Chinopoulos, C. & Patocs, A., Mar 2020, In : Cancers. 12, 3, 599.

Research output: Contribution to journalArticle

Open Access

Precision-engineered reporter cell lines reveal ABCG2 regulation in live lung cancer cells

Kovacsics, D., Brózik, A., Tihanyi, B., Matula, Z., Borsy, A., Mészáros, N., Szabó, E., Németh, E., Fóthi, Á., Zámbó, B., Szüts, D., Várady, G., Orbán, T. I., Apáti, A. & Sarkadi, B., May 2020, In : Biochemical Pharmacology. 175, 113865.

Research output: Contribution to journalArticle

Open Access

Synthesis and anticancer cytotoxicity of azaaurones overcoming multidrug resistance

Tóth, S., Szepesi, Á., Tran-Nguyen, V. K., Sarkadi, B., Német, K., Falson, P., Di Pietro, A., Szakács, G. & Boumendjel, A., Feb 10 2020, In : Molecules. 25, 3, 764.

Research output: Contribution to journalArticle

Open Access
2019

Germline BRCA1 mutation detected in a multiple Endocrine neoplasia type 2 case with RET codon 634 mutation

Sarkadi, B., Baghy, K., Sápi, Z., Nyirő, G., Likó, I. & Patócs, A., 2019, In : Frontiers in Genetics. 10, JUN, 544.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

A new fluorescent dye accumulation assay for parallel measurements of the ABCG2, ABCB1 and ABCC1 multidrug transporter functions

Szabó, E., Türk, D., Telbisz, Á., Kucsma, N., Horváth, T., Szakács, G., Homolya, L., Sarkadi, B. & Várady, G., Jan 2018, In : PloS one. 13, 1, e0190629.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Characterization of calcium signals in human induced pluripotent stem cell-derived dentate gyrus neuronal progenitors and mature neurons, stably expressing an advanced calcium indicator protein

Vőfély, G., Berecz, T., Szabó, E., Szebényi, K., Hathy, E., Orbán, T. I., Sarkadi, B., Homolya, L., Marchetto, M. C., Réthelyi, J. M. & Apáti, Á., Apr 2018, In : Molecular and Cellular Neuroscience. 88, p. 222-230 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters

Temesszentandrási-Ambrus, C., Tóth, S., Verma, R., Bánhegyi, P., Szabadkai, I., Baska, F., Szántai-Kis, C., Hartkoorn, R. C., Lingerfelt, M. A., Sarkadi, B., Szakács, G., Orfi, L., Nagaraja, V., Ekins, S. & Telbisz, Á., Sep 2018, In : PloS one. 13, 9, e0202749.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression

Zámbó, B., Bartos, Z., Mózner, O., Szabó, E., Várady, G., Poór, G., Pálinkás, M., Andrikovics, H., Hegedus, T., Homolya, L. & Sarkadi, B., Dec 1 2018, In : Scientific reports. 8, 1, 7487.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Generation of multidrug resistant human tissues by overexpression of the ABCG2 multidrug transporter in embryonic stem cells

Erdei, Z., Schamberger, A., Török, G., Szebényi, K., Várady, G., Orbán, T. I., Homolya, L., Sarkadi, B. & Apáti, Á., Apr 2018, In : PloS one. 13, 4, e0194925.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2017

ABCMdb reloaded: Updates on mutations in ATP binding cassette proteins

Tordai, H., Jakab, K., Gyimesi, G., András, K., Brózik, A., Sarkadi, B. & Hegedus, T., Jan 1 2017, In : Database. 2017, 1, bax023.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Extensive astrocyte synchronization advances neuronal coupling in slow wave activity in vivo

Szabó, Z., Héja, L., Szalay, G., Kékesi, O., Füredi, A., Szebényi, K., Dobolyi, Á., Orbán, T. I., Kolacsek, O., Tompa, T., Miskolczy, Z., Biczók, L., Rózsa, B., Sarkadi, B. & Kardos, J., Dec 1 2017, In : Scientific reports. 7, 1, 6018.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2016

Application of fluorescent dye substrates for functional characterization of ABC multidrug transporters at a single cell level

Nerada, Z., Hegyi, Z., Szepesi, Á., Tóth, S., Hegedüs, C., Várady, G., Matula, Z., Homolya, L., Sarkadi, B. & Telbisz, Á., Sep 1 2016, In : Cytometry Part A. 89, 9, p. 826-834 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Exogenous Nitric Oxide Protects Human Embryonic Stem Cell-Derived Cardiomyocytes against Ischemia/Reperfusion Injury

Pálóczi, J., Varga, Z. V., Apáti, Á., Szebényi, K., Sarkadi, B., Madonna, R., De Caterina, R., Csont, T., Eschenhagen, T., Ferdinandy, P. & Görbe, A., Jan 1 2016, In : Oxidative medicine and cellular longevity. 2016, 4298945.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Functional characterization of the ABCG2 5′ non-coding exon variants: Stem cell specificity, translation efficiency and the influence of drug selection

Sándor, S., Jordanidisz, T., Schamberger, A., Várady, G., Erdei, Z., Apáti, Á., Sarkadi, B. & Orbán, T. I., Jul 1 2016, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1859, 7, p. 943-951 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Jump into a new fold-A homology based model for the ABCG2/BCRP multidrug transporter

Lászloá, L., Sarkadi, B. & Hegedüs, T., Oct 2016, In : PloS one. 11, 10, e0164426.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

Klawitter, S., Fuchs, N. V., Upton, K. R., Muñoz-Lopez, M., Shukla, R., Wang, J., Garcia-Cañadas, M., Lopez-Ruiz, C., Gerhardt, D. J., Sebe, A., Grabundzija, I., Merkert, S., Gerdes, P., Pulgarin, J. A., Bock, A., Held, U., Witthuhn, A., Haase, A., Sarkadi, B., Löwer, J. & 7 others, Wolvetang, E. J., Martin, U., Ivics, Z., Izsvák, Z., Garcia-Perez, J. L., Faulkner, G. J. & Schumann, G. G., Jan 8 2016, In : Nature communications. 7, 10286.

Research output: Contribution to journalArticle

66 Citations (Scopus)

The importance of drug transporters in human pluripotent stem cells and in early tissue differentiation

Apáti, A., Szebényi, K., Erdei, Z., Várady, G., Orbán, T. I. & Sarkadi, B., Jan 2 2016, In : Expert Opinion on Drug Metabolism and Toxicology. 12, 1, p. 77-92 16 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2015

ABCG2 is a selectable marker for enhanced multilineage differentiation potential in periodontal ligament stem cells

Szepesi, Á., Matula, Z., Szigeti, A., Várady, G., Szabó, G., Uher, F., Sarkadi, B. & Német, K., Jan 15 2015, In : Stem Cells and Development. 24, 2, p. 244-252 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Alterations of membrane protein expression in red blood cells of Alzheimer's disease patients

Várady, G., Szabó, E., Fehér, Á., Németh, A., Zámbó, B., Pákáski, M., Janka, Z. & Sarkadi, B., Sep 1 2015, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 1, 3, p. 334-338 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A novel mathematical model describing adaptive cellular drug metabolism and toxicity in the chemoimmune system

Tóth, A., Brózik, A., Szakács, G., Sarkadi, B. & Hegedûs, T., Feb 20 2015, In : PloS one. 10, 2, e0115533.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Efficient generation of human embryonic stem cell-derived cardiac progenitors based on tissue-specific enhanced green fluorescence protein expression

Szebényi, K., Péntek, A., Erdei, Z., Várady, G., Orbán, T. I., Sarkadi, B. & Apáti, Á., Jan 1 2015, In : Tissue Engineering - Part C: Methods. 21, 1, p. 35-45 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells

Erdélyi-Belle, B., Török, G., Apáti, Á., Sarkadi, B., Schaff, Z., Kiss, A. & Homolya, L., Sep 28 2015, In : Pathology and Oncology Research. 21, 4, p. 1059-1070 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling

Szebenyi, K., Füredi, A., Kolacsek, O., Pergel, E., Bosze, Z., Bender, B., Vajdovich, P., Tovari, J., Homolya, L., Szakacs, G., Heja, L., Enyedi, A., Sarkadi, B., Apati, A. & Orban, T. I., Aug 3 2015, In : Scientific reports. 5, 12645.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Inconsistencies in the red blood cell membrane proteome analysis: Generation of a database for research and diagnostic applications

Hegedus, T., Chaubey, P. M., Várady, G., Szabó, E., Sarankó, H., Hofstetter, L., Roschitzki, B., Stieger, B. & Sarkadi, B., 2015, In : Database. 2015, bav056.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Mesenchymal Stromal Cell-Like Cells Set the Balance of Stimulatory and Inhibitory Signals in Monocyte-Derived Dendritic Cells

Bacskai, I., Mázló, A., Kis-Tóth, K., Szabó, A., Panyi, G., Sarkadi, B., Apáti, Á. & Rajnavölgyi, É., Aug 1 2015, In : Stem Cells and Development. 24, 15, p. 1805-1816 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
14 Citations (Scopus)

Visualization of calcium dynamics in kidney proximal tubules

Szebényi, K., Füredi, A., Kolacsek, O., Csohány, R., Prókai, Á., Kis-Petik, K., Szabó, A., Bosze, Z., Bender, B., Tóvári, J., Enyedi, Á., Orbán, T. I., Apáti, Á. & Sarkadi, B., Nov 2015, In : Journal of the American Society of Nephrology. 26, 11, p. 2731-2740 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2014

Excision efficiency is not strongly coupled to transgenic rate: Cell type-dependent transposition efficiency of sleeping beauty and piggy bac DNA transposons

Kolacsek, O., Erdei, Z., Apáti, Á., Sándor, S., Izsvák, Z., Ivics, Z., Sarkadi, B. & Orbán, T. I., Aug 1 2014, In : Human Gene Therapy Methods. 25, 4, p. 241-252 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Expression pattern of the human ABC transporters in pluripotent embryonic stem cells and in their derivatives

Erdei, Z., Lorincz, R., Szebényi, K., Péntek, A., Varga, N., Likó, I., Várady, G., Szakács, G., Orbán, T. I., Sarkadi, B. & Apáti, Á., Sep 2014, In : Cytometry Part B - Clinical Cytometry. 86, 5, p. 299-310 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
24 Citations (Scopus)

Screening the expression of ABCB6 in erythrocytes reveals an unexpectedly high frequency of Lan mutations in healthy Individuals

Koszarska, M., Kucsma, N., Kiss, K., Varady, G., Gera, M., Antalffy, G., Andrikovics, H., Tordai, A., Studzian, M., Strapagiel, D., Pulaski, L., Tani, Y., Sarkadi, B. & Szakacs, G., Oct 31 2014, In : PloS one. 9, 10, e111590.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2013

ABCC6 is a basolateral plasma membrane protein

Pomozi, V., Le Saux, O., Brampton, C., Apana, A., Iliás, A., Szeri, F., Martin, L., Monostory, K., Paku, S., Sarkadi, B., Szakács, G. & Váradi, A., May 24 2013, In : Circulation research. 112, 11, p. e148-e151

Research output: Contribution to journalArticle

33 Citations (Scopus)

ABCG2 is not able to catalyze glutathione efflux and does not contribute to GSH-dependent collateral sensitivity

Gauthier, C., Ozvegy-Laczka, C., Szakacs, G., Sarkadi, B. & Pietro, A. D., 2013, In : Frontiers in Pharmacology. 4 NOV, Article 138.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Characterization of calcium signals in human embryonic stem cells and in their differentiated offspring by a stably integrated calcium indicator protein

Apáti, Á., Pászty, K., Hegedus, L., Kolacsek, O., Orbán, T. I., Erdei, Z., Szebényi, K., Péntek, A., Enyedi, Á. & Sarkadi, B., Apr 1 2013, In : Cellular Signalling. 25, 4, p. 752-759 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Dynamic ABCG2 expression in human embryonic stem cells provides the basis for stress response

Erdei, Z., Sarkadi, B., Brózik, A., Szebényi, K., Várady, G., Makó, V., Péntek, A., Orbán, T. I. & Apáti, Á., Mar 1 2013, In : European Biophysics Journal. 42, 2-3, p. 169-179 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
20 Citations (Scopus)
28 Citations (Scopus)

Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells

Grabundzija, I., Wang, J., Sebe, A., Erdei, Z., Kajdi, R., Devaraj, A., Steinemann, D., Szuhai, K., Stein, U., Cantz, T., Schambach, A., Baum, C., Izsvák, Z., Sarkadi, B. & Ivics, Z., Feb 1 2013, In : Nucleic acids research. 41, 3, p. 1829-1847 19 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Structure-activity relationships of chromone derivatives toward the mechanism of interaction with and inhibition of breast cancer resistance protein ABCG2

Winter, E., Lecerf-Schmidt, F., Gozzi, G., Peres, B., Lightbody, M., Gauthier, C., Ozvegy-Laczka, C., Szakacs, G., Sarkadi, B., Creczynski-Pasa, T. B., Boumendjel, A. & Di Pietro, A., Dec 27 2013, In : Journal of Medicinal Chemistry. 56, 24, p. 9849-9860 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2012

ABCMdb: A database for the comparative analysis of protein mutations in ABC transporters, and a potential framework for a general application

Gyimesi, G., Borsodi, D., Sarankó, H., Tordai, H., Sarkadi, B. & Hegedu double acutes, T., Nov 1 2012, In : Human mutation. 33, 11, p. 1547-1556 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Antibody binding shift assay for rapid screening of drug interactions with the human ABCG2 multidrug transporter

Telbisz, Á., Hegedüs, C., Özvegy-Laczka, C., Goda, K., Várady, G., Takáts, Z., Szabó, E., Sorrentino, B. P., Váradi, A. & Sarkadi, B., Jan 23 2012, In : European Journal of Pharmaceutical Sciences. 45, 1-2, p. 101-109 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Expression Levels of the ABCG2 Multidrug Transporter in Human Erythrocytes Correspond to Pharmacologically Relevant Genetic Variations

Kasza, I., Várady, G., Andrikovics, H., Koszarska, M., Tordai, A., Scheffer, G. L., Németh, A., Szakács, G. & Sarkadi, B., Nov 15 2012, In : PloS one. 7, 11, e48423.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Human mirtrons can express functional microRNAs simultaneously from both arms in a flanking exon-independent manner

Schamberger, A., Sarkadi, B. & Orbán, T. I., Sep 2012, In : RNA Biology. 9, 9, p. 1177-1185 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
45 Citations (Scopus)

PI3-kinase and mTOR inhibitors differently modulate the function of the ABCG2 multidrug transporter

Hegedüs, C., Truta-Feles, K., Antalffy, G., Brózik, A., Kasza, I., Német, K., Orbán, T. I., Özvegy-Laczka, C., Váradi, A. & Sarkadi, B., Apr 20 2012, In : Biochemical and biophysical research communications. 420, 4, p. 869-874 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Stimulus-induced expression of the ABCG2 multidrug transporter in HepG2 hepatocarcinoma model cells involves the ERK1/2 cascade and alternative promoters

de Boussac, H., Orbán, T. I., Várady, G., Tihanyi, B., Bacquet, C., Brózik, A., Váradi, A., Sarkadi, B. & Arányi, T., Sep 21 2012, In : Biochemical and biophysical research communications. 426, 2, p. 172-176 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2011

ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: Relevance to pathomechanisms of pseudoxanthoma elasticum

Fülöp, K., Jiang, Q., Wetering, K. V. D., Pomozi, V., Szabó, P. T., Arányi, T., Sarkadi, B., Borst, P., Uitto, J. & Váradi, A., Nov 25 2011, In : Biochemical and biophysical research communications. 415, 3, p. 468-471 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

ABC transporters affect the detection of intracellular oxidants by fluorescent probes

Procházková, J., Kubala, L., Kotasovǎ, H., Gudernovǎ, I., Šrǎmkovǎ, Z., Pekarovǎ, M., Sarkadi, B. & Pachernǐk, J., Jul 2011, In : Free radical research. 45, 7, p. 779-787 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)