• 10112 Citations
  • 51 h-Index
1970 …2019

Research output per year

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Research Output

2019

Effects of the pentapeptide p33 on memory and synaptic plasticity in app/ps1 transgenic mice: a novel mechanism presenting the protein fe65 as a target

Szögi, T., Schuster, I., Borbély, E., Gyebrovszki, A., Bozsó, Z., Gera, J., Rajkó, R., Sántha, M., Penke, B. & Fülöp, L., Jun 2 2019, In : International journal of molecular sciences. 20, 12, 3050.

Research output: Contribution to journalArticle

Open Access

Key peptides and proteins in alzheimer’s disease

Penke, B., Bogár, F., Paragi, G., Gera, J. & Fülöp, L., Jan 1 2019, In : Current Protein and Peptide Science. 20, 6, p. 577-599 23 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)
2018

Cerebrovascular pathology in hypertriglyceridemic APOB-100 transgenic mice

Hoyk, Z., Tóth, M. E., Lénárt, N., Nagy, D., Dukay, B., Csefová, A., Zvara, A., Seprényi, G., Kincses, A., Walter, F. R., Veszelka, S., Vígh, J., Barabási, B., Harazin, A., Kittel, A., Puskás, L., Penke, B., Vígh, L., Deli, M. A. & Sántha, M., Oct 25 2018, In : Frontiers in Cellular Neuroscience. 12, 380.

Research output: Contribution to journalArticle

2 Citations (Scopus)
13 Citations (Scopus)

The role of lipids and membranes in the pathogenesis of alzheimer's disease: A comprehensive view

Penke, B., Paragi, G., Gera, J., Berkecz, R., Kovács, Z., Crul, T. & Vígh, L., Jan 1 2018, In : Current Alzheimer Research. 15, 13, p. 1191-1212 22 p.

Research output: Contribution to journalReview article

13 Citations (Scopus)

The role of sigma-1 receptor, an intracellular chaperone in neurodegenerative diseases

Penke, B., Fülöp, L., Szűcs, M. & Frecska, E., Jan 1 2018, In : Current neuropharmacology. 16, 1, p. 97-116 20 p.

Research output: Contribution to journalReview article

20 Citations (Scopus)
2017

Mitochondrial Proteome Changes Correlating with β-Amyloid Accumulation

Völgyi, K., Háden, K., Kis, V., Gulyássy, P., Badics, K., Györffy, B. A., Simor, A., Szabó, Z., Janáky, T., Drahos, L., Dobolyi, Á., Penke, B., Juhász, G. & Kékesi, K. A., Apr 1 2017, In : Molecular Neurobiology. 54, 3, p. 2060-2078 19 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Studies for improving a rat model of Alzheimer's disease: ICV administration of well-characterized β-amyloid 1-42 oligomers induce dysfunction in spatial memory

Kasza, Á., Penke, B., Frank, Z., Bozsó, Z., Szegedi, V., Hunya, Á., Németh, K., Kozma, G. & Fülöp, L., Nov 1 2017, In : Molecules. 22, 11, 2007.

Research output: Contribution to journalArticle

15 Citations (Scopus)

β-amyloid and the pathomechanisms of Alzheimer’s disease: A comprehensive view

Penke, B., Bogár, F. & F l, L., Oct 1 2017, In : Molecules. 22, 10, 1692.

Research output: Contribution to journalReview article

29 Citations (Scopus)
2016

Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease

Kasza, Á., Hunya, Á., Frank, Z., Fülöp, F., Török, Z., Balogh, G., Sántha, M., Bálind, Á., Bernáth, S., Blundell, K. L. I. M., Prodromou, C., Horváth, I., Zeiler, H. J., Hooper, P. L., Vígh, L., Penke, B. & Abisambra, J., 2016, In : Journal of Alzheimer's Disease. 53, 2, p. 557-571 15 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

New small-size peptides modulators of the exosite of BACE1 obtained from a structure-based design

Gutierrez, L. J., Angelina, E., Gyebrovszki, A., Fülöp, L., Peruchena, N., Baldoni, H. A., Penke, B. & Enriz, R. D., Feb 24 2016, (Accepted/In press) In : Journal of Biomolecular Structure and Dynamics. p. 1-14 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
20 Citations (Scopus)
2015
11 Citations (Scopus)

Amyloid-β1-42 Disrupts Synaptic Plasticity by Altering Glutamate Recycling at the Synapse

Varga, E., Juhász, G., Bozsó, Z., Penke, B., Fülöp, L. & Szegedi, V., Jan 1 2015, In : Journal of Alzheimer's Disease. 45, 2, p. 449-456 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
33 Citations (Scopus)

Opposite effect of Ca2+/Mg2+ ions on the aggregation of native and precursor-derived Aβ42

Bogár, F., Simon, D., Bozsó, Z., Janáky, T., Veszelka, S., Tóth, A. E., Deli, M. A., Borics, A., Násztor, Z., Gyebrovszki, A., Penke, B. & Fülöp, L., Dec 1 2015, In : Structural Chemistry. 26, 5-6, p. 1389-1403 15 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
5 Citations (Scopus)
2014

Abeta(1-42) enhances neuronal excitability in the CA1 via NR2B subunit-containing NMDA receptors

Varga, E., Juhász, G., Bozsó, Z., Penke, B., Fülöp, L. & Szegedi, V., Jan 1 2014, In : Neural Plasticity. 2014, 584314.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array

May, C., Nordhoff, E., Casjens, S., Turewicz, M., Eisenacher, M., Gold, R., Brüning, T., Pesch, B., Stephan, C., Woitalla, D., Penke, B., Janáky, T., Virók, D., Siklós, L., Engelhardt, J. I. & Meyer, H. E., Feb 26 2014, In : PloS one. 9, 2, e89596.

Research output: Contribution to journalArticle

19 Citations (Scopus)
13 Citations (Scopus)

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

Koivisto, H., Grimm, M. O., Rothhaar, T. L., Berkecz, R., Lütjohann D, D., Giniatullina, R., Takalo, M., Miettinen, P. O., Lahtinen, H. M., Giniatullin, R., Penke, B., Janáky, T., Broersen, L. M., Hartmann, T. & Tanila, H., Feb 1 2014, In : Journal of Nutritional Biochemistry. 25, 2, p. 157-169 13 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2013

Docosahexaenoic acid reduces amyloid-β induced toxicity in cells of the neurovascular unit

Veszelka, S., Tóth, A. E., Walter, F. R., Datki, Z., Mózes, E., Fülöp, L., Bozsó, Z., Hellinger, É., Vastag, M., Orsolits, B., Környei, Z., Penke, B. & Deli, M. A., 2013, In : Journal of Alzheimer's Disease. 36, 3, p. 487-501 15 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Epitaxial assembly dynamics of mutant amyloid β25-35-N27C fibrils explored with time-resolved scanning force microscopy

Kellermayer, M. S. Z., Murvai, Ü., Horváth, A., Lászlóffi, E., Soós, K. & Penke, B., Jan 1 2013, In : Biophysical Chemistry. 184, p. 54-61 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Overexpression of Hsp27 ameliorates symptoms of Alzheimer's disease in APP/PS1 mice

Tóth, M. E., Szegedi, V., Varga, E., Juhász, G., Horváth, J., Borbély, E., Csibrány, B., Alföldi, R., Lénárt, N., Penke, B. & Sántha, M., Apr 22 2013, In : Cell Stress and Chaperones. 18, 6, p. 759-771 13 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Penetratin and derivatives acting as antibacterial agents

Garro, A. D., Olivella, M. S., Bombasaro, J. A., Lima, B., Tapia, A., Feresin, G., Perczel, A., Somlai, C., Penke, B., López Cascales, J., Rodríguez, A. M. & Enriz, R. D., Aug 1 2013, In : Chemical Biology and Drug Design. 82, 2, p. 167-177 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Proteome-wide study of endoplasmic reticulum stress induced by thapsigargin in N2a neuroblastoma cells

Földi, I., Tóth, A. M., Szabó, Z., Mózes, E., Berkecz, R., Datki, Z. L., Penke, B. & Janáky, T., Jan 1 2013, In : Neurochemistry international. 62, 1, p. 58-69 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Tenascin-C deficiency ameliorates alzheimer's disease-related pathology in mice

Xie, K., Liu, Y., Hao, W., Walter, S., Penke, B., Hartmann, T., Schachner, M. & Fassbender, K., Oct 1 2013, In : Neurobiology of Aging. 34, 10, p. 2389-2398 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2012

Altered Functional Protein Networks in the Prefrontal Cortex and Amygdala of Victims of Suicide

Kékesi, K. A., Juhász, G., Simor, A., Gulyássy, P., Szego, É. M., Hunyadi-Gulyás, É., Darula, Z., Medzihradszky, K. F., Palkovits, M., Penke, B. & Czurkó, A., Dec 6 2012, In : PloS one. 7, 12, e50532.

Research output: Contribution to journalArticle

36 Citations (Scopus)

A novel method for the rapid determination of beta-amyloid toxicity on acute hippocampal slices using MTT and LDH assays

Mozes, E., Hunya, A., Posa, A., Penke, B. & Datki, Z., Apr 10 2012, In : Brain Research Bulletin. 87, 6, p. 521-525 5 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Conformational dynamics of titin PEVK explored with FRET spectroscopy

Huber, T., Grama, L., Hetényi, C., Schay, G., Fülöp, L., Penke, B. & Kellermayer, M. S. Z., Oct 3 2012, In : Biophysical journal. 103, 7, p. 1480-1489 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

GluA1 phosphorylation alters evoked firing pattern in vivo

Barkczi, B., Juhász, G., Averkin, R. G., Vrs, I., Vertes, P., Penke, B. & Szegedi, V., Jan 1 2012, In : Neural Plasticity. 2012, 286215.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Increased Tau Phosphorylation and Impaired Presynaptic Function in Hypertriglyceridemic ApoB-100 Transgenic Mice

Lénárt, N., Szegedi, V., Juhász, G., Kasztner, A., Horváth, J., Bereczki, E., Tóth, M. E., Penke, B. & Sántha, M., Sep 24 2012, In : PloS one. 7, 9, e46007.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Intraneuronal β-amyloid and its interactions with proteins and subcellular organelles

Penke, B., Tóth, A. M., Földi, I., Szucs, M. & Janáky, T., Dec 1 2012, In : ELECTROPHORESIS. 33, 24, p. 3608-3616 9 p.

Research output: Contribution to journalReview article

21 Citations (Scopus)

Synthesis and cytotoxic activity of 4-N-carboxybutyl-5-fluorocytosyl-Arg- Gln-Trp-Arg-Arg-Trp-Trp-Gln-Arg-NH 2

Somlai, C., Correche, E., Olivella, M., Tolosa, L., Lechon, M. J. G., Dombi, G., Tóth, G. K., Penke, B. & Enriz, R. D., Jul 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 13, p. 4233-4237 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation

Liu, S., Liu, Y., Hao, W., Wolf, L., Kiliaan, A. J., Penke, B., Rübe, C. E., Walter, J., Heneka, M. T., Hartmann, T., Menger, M. D. & Fassbender, K., Feb 1 2012, In : Journal of Immunology. 188, 3, p. 1098-1107 10 p.

Research output: Contribution to journalArticle

188 Citations (Scopus)
2011

A novel application of the fluorescent dye bis-ANS for labeling neurons in acute brain slices

Mozes, E., Hunya, A., Toth, A., Ayaydin, F., Penke, B. & Datki, Z. L., Oct 10 2011, In : Brain Research Bulletin. 86, 3-4, p. 217-221 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Characterisation of the variation of mouse brain proteome by two-dimensional electrophoresis

Földi, I., Müller, G., Penke, B. & Janáky, T., May 16 2011, In : Journal of proteomics. 74, 6, p. 894-901 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Docosahexaenoic acid reduces amyloid β production via multiple pleiotropic mechanisms

Grimm, M. O. W., Kuchenbecker, J., Grosgen, S., Burg, V. K., Hundsdorfer, B., Rothhaar, T. L., Friess, P., De Wilde, M. C., Broersen, L. M., Penke, B., Peter, M., Vígh, L., Grimm, H. S. & Hartmann, T., Apr 22 2011, In : Journal of Biological Chemistry. 286, 16, p. 14028-14039 12 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)

Effect of the beta-sheet-breaker peptide LPFFD on oriented network of amyloid β25-35 fibrils

Murvai, Ü., Soós, K., Penke, B. & Kellermayer, M. S. Z., May 1 2011, In : Journal of Molecular Recognition. 24, 3, p. 453-460 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Effects of estrogen on beta-amyloid-induced cholinergic cell death in the nucleus basalis magnocellularis

Szego, É. M., Csorba, A., Janáky, T., Kékesi, K. A., Ábrahám, I. M., Mórotz, G. M., Penke, B., Palkovits, M., Murvai, Ü., Kellermayer, M. S. Z., Kardos, J. & Juhász, G. D., Mar 1 2011, In : Neuroendocrinology. 93, 2, p. 90-105 16 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Exploring and characterizing the folding processes of Lys- and Arg-containing Ala-based peptides: A molecular dynamics study

Janzsó, G., Bogár, F., Hudoba, L., Penke, B., Rákhely, G. & Leitgeb, B., Aug 10 2011, In : Computational Biology and Chemistry. 35, 4, p. 240-250 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
6 Citations (Scopus)

Helix and H-bond formations of alanine-based peptides containing basic amino acids

Leitgeb, B., Janzsó, G., Hudoba, L., Penke, B., Rákhely, G. & Bogár, F., Dec 1 2011, In : Structural Chemistry. 22, 6, p. 1287-1295 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Interactions of pathological hallmark proteins: Tubulin polymerization promoting protein/p25,β-amyloid, and α-synuclein

Oláh, J., Vincze, O., Virók, D., Simon, D., Bozsó, Z., Tokési, N., Horváth, I., Hlavanda, E., Kovács, J., Magyar, A., Szucs, M., Orosz, F., Penke, B. & Ovádi, J., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 34088-34100 13 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer's disease-related symptoms and pathology

Hao, W., Liu, Y., Liu, S., Walter, S., Grimm, M. O., Kiliaan, A. J., Penke, B., Hartmann, T., Rübe, C. E., Menger, M. D. & Fassbender, K., Jan 2011, In : Brain. 134, 1, p. 278-292 15 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Neuroprotective effects of a specific multi-nutrient intervention against Aβ42-induced toxicity in rats

De Wilde, M. C., Penke, B., Van Der Beek, E. M., Kuipers, A. A. M., Kamphuis, P. J. & Broersen, L. M., 2011, In : Journal of Alzheimer's Disease. 27, 2, p. 327-339 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Neutral and positively charged new purine tetramer structures: A computational study of xanthine and uric acid derivatives

Paragi, G., Kovács, L., Kupihár, Z., Szolomájer, J., Penke, B., Fonseca Guerra, C. & Bickelhaupt, F. M., Jan 1 2011, In : New Journal of Chemistry. 35, 1, p. 119-126 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

New small-size antifungal peptides: Design, synthesis and antifungal activity

Garro, A. D., Garibotto, F. M., Rodriguez, A. M., Raimondi, M., Zacchino, S. A., Perczel, A., Somlai, C., Penke, B. & Enriz, R. D., Jul 1 2011, In : Letters in Drug Design and Discovery. 8, 6, p. 562-567 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Penetratin analogues acting as antifungal agents

Garibotto, F. M., Garro, A. D., Rodríguez, A. M., Raimondi, M., Zacchino, S. A., Perczel, A., Somlai, C., Penke, B. & Enriz, R. D., Jan 1 2011, In : European Journal of Medicinal Chemistry. 46, 1, p. 370-377 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation

Virok, D. P., Simon, D., Bozsó, Z., Rajkó, R., Datki, Z., Bálint, É., Szegedi, V., Janáky, T., Penke, B. & Fülöp, L., Apr 1 2011, In : Journal of Proteome Research. 10, 4, p. 1538-1547 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)