• 6051 Citations
  • 41 h-Index
1988 …2019
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Research Output 1988 2019

2019
Open Access
Switches
GTPase-Activating Proteins
Guanine Nucleotide Exchange Factors
ras Proteins
Monomeric GTP-Binding Proteins
Open Access
Dichroism
Nuclear magnetic resonance spectroscopy
Amino acids
Diamide
Amino Acids
Open Access
Water
Proteins
Temperature
Ice
Molecular Dynamics Simulation

Protein aggregation in a nutshell: The splendid molecular architecture of the dreaded amyloid fibrils

Horváth, D., Menyhárd, D. K. & Perczel, A., Jan 1 2019, In : Current Protein and Peptide Science. 20, 11, p. 1077-1088 12 p.

Research output: Contribution to journalReview article

Amyloid
Agglomeration
Proteins
Peptides
Physiology

Unwanted hydrolysis or α/β-peptide bond formation: How long should the rate-limiting coupling step take?

Goldschmidt Gőz, V., Nagy, A., Farkas, V., Keszei, E. & Perczel, A., Jan 1 2019, In : RSC Advances. 9, 53, p. 30720-30728 9 p.

Research output: Contribution to journalArticle

Open Access
Peptides
Amino acids
Hydrolysis
Esters
Amino Acids
1 Citation (Scopus)

α/β-Chimera peptide synthesis with cyclic β-sugar amino acids: the efficient coupling protocol

Nagy, A., Goldschmidt Gőz, V., Pintér, I., Farkas, V. & Perczel, A., Jan 1 2019, In : Amino Acids.

Research output: Contribution to journalArticle

Cyclic Amino Acids
Sugar Acids
Sugars
Amino Acids
Peptides
2018
2 Citations (Scopus)

Approaches to Pyranuronic β-Sugar Amino Acid Building Blocks of Peptidosaccharide Foldamers

Goldschmidt Gőz, V., Pintér, I., Harmat, V. & Perczel, A., Jan 23 2018, In : European Journal of Organic Chemistry. 2018, 3, p. 355-361 7 p.

Research output: Contribution to journalArticle

sugars
Sugars
amino acids
Amino Acids
synthesis
1 Citation (Scopus)

Biochemical and pharmacological characterization of three opioid-nociceptin hybrid peptide ligands reveals substantially differing modes of their actions

Erdei, A., Borbély, A., Magyar, A., Taricska, N., Perczel, A., Zsíros, O., Garab, G., Szűcs, E., Ötvös, F., Zádor, F., Balogh, M., Al-Khrasani, M. & Benyhe, S., Jan 1 2018, In : Peptides. 99, p. 205-216 12 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Pharmacology
Ligands
Peptides
Vas Deferens
2 Citations (Scopus)

C-terminal oligomerization of podocin mediates interallelic interactions

Stráner, P., Balogh, E., Schay, G., Arrondel, C., Mikó, Á., L'Auné, G., Benmerah, A., Perczel, A., K. Menyhárd, D., Antignac, C., Mollet, G. & Tory, K., Jul 1 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 7, p. 2448-2457 10 p.

Research output: Contribution to journalArticle

Membranes
Dimerization
Circular Dichroism
Endocytosis
Diaphragm
2017
5 Citations (Scopus)

C-3 epimers of sugar amino acids as foldameric building blocks: improved synthesis, useful derivatives, coupling strategies

Nagy, A., Csordás, B., Zsoldos-Mády, V., Pintér, I., Farkas, V. & Perczel, A., Feb 1 2017, In : Amino Acids. 49, 2, p. 223-240 18 p.

Research output: Contribution to journalArticle

Sugar Acids
Sugars
Stereoisomerism
Derivatives
Amino Acids
8 Citations (Scopus)

Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins

Szénási, T., Oláh, J., Szabó, A., Szunyogh, S., Láng, A., Perczel, A., Lehotzky, A., Uversky, V. N. & Ovádi, J., Jan 1 2017, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1863, 1, p. 310-323 14 p.

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Lizards
Parkinson Disease
Tubulin
3 Citations (Scopus)

Four faces of the interaction between ions and aromatic rings

Papp, D., Rovó, P., Jákli, I., Császár, A. & Perczel, A., Jul 30 2017, In : Journal of Computational Chemistry. 38, 20, p. 1762-1773 12 p.

Research output: Contribution to journalArticle

Cations
Positive ions
Face
Ions
Ring
2 Citations (Scopus)

Predictable Conformational Diversity in Foldamers of Sugar Amino Acids

Menyhárd, D. K., Hudáky, I., Jákli, I., Juhász, G. & Perczel, A., Apr 24 2017, In : Journal of Chemical Information and Modeling. 57, 4, p. 757-768 12 p.

Research output: Contribution to journalArticle

Sugars
Amino acids
Stereochemistry
NSC 153174
Carboxylic Acids

Protein modeling

Náray-Szabó, G., Perczel, A., Láng, A. & Menyhárd, D. K., Jan 1 2017, Handbook of Computational Chemistry. Springer International Publishing, p. 1589-1626 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Proteins
Protein
Modeling
Computer Modeling
proteins

The impact of water on the ambivalent behavior and paradoxical phenomenon of the amyloid-β fibril protein

Vajda, T. & Perczel, A., Dec 20 2017, In : Biomolecular Concepts. 8, 5-6, p. 213-220 8 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Amyloid
Water
A 17
Proteins
2016
2 Citations (Scopus)

Aromatic Cluster Sensor of Protein Folding: Near-UV Electronic Circular Dichroism Bands Assigned to Fold Compactness

Farkas, V., Jákli, I., Tóth, G. & Perczel, A., Sep 19 2016, In : Chemistry - A European Journal. 22, 39, p. 13871-13883 13 p.

Research output: Contribution to journalArticle

Protein folding
Dichroism
Sensors
Proteins
Nuclear magnetic resonance
Protein folding
Sensors
Circular Dichroism
4 Citations (Scopus)
Solid-Phase Synthesis Techniques
Ligands
Amino Acids
Peptides
Escherichia coli

Hydrogen-Bonding Network Anchors the Cyclic Form of Sugar Arylhydrazones

Goldschmidt Goz, V., Pintér, I., Csámpai, A., Jákli, I., Zsoldos-Mády, V. & Perczel, A., 2016, (Accepted/In press) In : European Journal of Organic Chemistry.

Research output: Contribution to journalArticle

Glucosamine
Hydrogen Bonding
sugars
Anchors
Sugars
5 Citations (Scopus)

Origin of problems related to Staudinger reduction in carbopeptoid syntheses

Csordás, B., Nagy, A., Harmat, V., Zsoldos-Mády, V., Leveles, I., Pintér, I., Farkas, V. & Perczel, A., Jul 20 2016, (Accepted/In press) In : Amino Acids. p. 1-15 15 p.

Research output: Contribution to journalArticle

Peptides
Derivatives
Amino Acids
Sugar Acids
Rubiaceae
3 Citations (Scopus)

Small Peptides Derived from Penetratin as Antibacterial Agents

Parravicini, O., Somlai, C., Andujar, S. A., Garro, A. D., Lima, B., Tapia, A., Feresin, G., Perczel, A., Tóth, G., Cascales, J. L., Rodríguez, A. M. & Enriz, R. D., 2016, (Accepted/In press) In : Archiv der Pharmazie.

Research output: Contribution to journalArticle

Anti-Bacterial Agents
Peptides
Trifluoroethanol
Water
Molecular Dynamics Simulation
1 Citation (Scopus)

The clear and dark sides of water: Influence on the coiled coil folding domain

Vajda, T. & Perczel, A., Jun 1 2016, In : Biomolecular Concepts. 7, 3, p. 189-195 7 p.

Research output: Contribution to journalReview article

Water
Oligomerization
Expert Testimony
Amyloidosis
Proteins
2015
8 Citations (Scopus)

Development of cyclic NGR peptides with thioether linkage: Structure and dynamics determining deamidation and bioactivity

Enyedi, K. N., Czajlik, A., Knapp, K., Láng, A., Majer, Z., Lajkó, E., Kőhidai, L., Perczel, A. & Mező, G., Feb 26 2015, In : Journal of Medicinal Chemistry. 58, 4, p. 1806-1817 12 p.

Research output: Contribution to journalArticle

NGR peptide
Cyclic Peptides
Sulfides
Cell Adhesion
Drug Delivery Systems
7 Citations (Scopus)

Phosphorylation as conformational switch from the native to amyloid state: Trp-cage as a protein aggregation model

Kardos, J., Kiss, B., Micsonai, A., Rovó, P., Menyhárd, D. K., Kovács, J., Váradi, G., Tóth, G. & Perczel, A., Feb 19 2015, In : Journal of Physical Chemistry B. 119, 7, p. 2946-2955 10 p.

Research output: Contribution to journalArticle

phosphorylation
Phosphorylation
Amyloid
Agglomeration
switches
2014
4 Citations (Scopus)

A theoretical study of the stability of disulfide bridges in various β-sheet structures of protein segment models

Galant, N. J., Song, H. C., Jákli, I., Viskolcz, B., Csizmadia, I., Knak Jensen, S. J. & Perczel, A., Feb 11 2014, In : Chemical Physics Letters. 593, p. 48-54 7 p.

Research output: Contribution to journalArticle

disulfides
Disulfides
strands
proteins
Stabilization

Dynamics of small, folded proteins

Rovó, P., Menyhárd, D. K., Náray-Szabó, G. & Perczel, A., Jul 1 2014, Protein Modelling. Springer International Publishing, p. 223-248 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Proteins
Nuclear magnetic resonance spectroscopy
Electrostatics
NPHS2 protein
9 Citations (Scopus)

DYNLL2 dynein light chain binds to an extended linear motif of myosin 5a tail that has structural plasticity

Bodor, A., Radnai, L., Hetényi, C., Rapali, P., Láng, A., Kövér, K. E., Perczel, A., Wahlgren, W. Y., Katona, G. & Nyitray, L., Nov 18 2014, In : Biochemistry. 53, 45, p. 7107-7122 16 p.

Research output: Contribution to journalArticle

Dyneins
Myosins
Plasticity
Peptides
Proteins
2 Citations (Scopus)

Impairment of a model peptide by oxidative stress: Thermodynamic stabilities of asparagine diamide Cα-radical foldamers

Gerlei, K. Z., Élo, L., Fiser, B., Owen, M. C., Jákli, I., Knak Jensen, S. J., Csizmadia, I., Perczel, A. & Viskolcz, B., Feb 11 2014, In : Chemical Physics Letters. 593, p. 104-108 5 p.

Research output: Contribution to journalArticle

Diamide
Oxidative stress
Asparagine
impairment
peptides
71 Citations (Scopus)

Mutation-dependent recessive inheritance of NPHS2-associated steroid-resistant nephrotic syndrome

Tory, K., Menyhárd, D. K., Woerner, S., Nevo, F., Gribouval, O., Kerti, A., Stráner, P., Arrondel, C., Cong, E. H., Tulassay, T., Mollet, G., Perczel, A. & Antignac, C., 2014, In : Nature Genetics. 46, 3, p. 299-304 6 p.

Research output: Contribution to journalArticle

Nephrotic Syndrome
Alleles
Steroids
Mutation
Virulence
1 Citation (Scopus)

Quantum chemical calculations on small protein models

Jákli, I., Perczel, A., Viskolcz, B. & Csizmadia, I., Jul 1 2014, Protein Modelling. Springer International Publishing, p. 5-50 46 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Potential energy surfaces
Peptides
Proteins
Protein folding
Oligopeptides
10 Citations (Scopus)

Rational design of α-helix-stabilized exendin-4 analogues

Rovó, P., Farkas, V., Stráner, P., Szabó, M., Jermendy, Á., Hegyi, O., Tóth, G. & Perczel, A., Jun 10 2014, In : Biochemistry. 53, 22, p. 3540-3552 13 p.

Research output: Contribution to journalArticle

Solubility
Magnetic Resonance Spectroscopy
Magnetic resonance measurement
Lead compounds
Amino Acids
11 Citations (Scopus)

Role of water in protein folding, oligomerization, amyloidosis and miniprotein

Vajda, T. & Perczel, A., Oct 1 2014, In : Journal of Peptide Science. 20, 10, p. 747-759 13 p.

Research output: Contribution to journalArticle

Protein folding
Oligomerization
Protein Folding
Amyloidosis
Water
2013
6 Citations (Scopus)

Atropisomerism of the Asn α radicals revealed by ramachandran surface topology

Gerlei, K. Z., Jákli, I., Szori, M., Jensen, S. J. K., Viskolcz, B., Csizmadia, I. & Perczel, A., Oct 17 2013, In : Journal of Physical Chemistry B. 117, 41, p. 12402-12409 8 p.

Research output: Contribution to journalArticle

Amino acids
topology
Topology
Amino Acids
amino acids
8 Citations (Scopus)

Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling

Barabás, O., Németh, V., Bodor, A., Perczel, A., Rosta, E., Kele, Z., Zagyva, I., Szabadka, Z., Grolmusz, V. I., Wilmanns, M. & Vértessy, B., Dec 2013, In : Nucleic Acids Research. 41, 22, p. 10542-10555 14 p.

Research output: Contribution to journalArticle

Magnetic Resonance Spectroscopy
Phosphates
X-Rays
Mechanics
Nucleosides
6 Citations (Scopus)

Foldamers of β-peptides: Conformational preference of peptides formed by rigid building blocks. the first MI-IR spectra of a triamide nanosystem

Pohl, G., Gorrea, E., Branchadell, V., Ortuño, R. M., Perczel, A. & Tarczay, G., 2013, In : Amino Acids. 45, 4, p. 957-973 17 p.

Research output: Contribution to journalArticle

Nanosystems
Chirality
Noble Gases
Oligopeptides
Peptides
7 Citations (Scopus)

Foldamer stability coupled to aggregation propensity of elongated trp-cage miniproteins

Farkas, V., Csordás, B., Hegyi, O., Tóth, G. & Perczel, A., Jun 2013, In : European Journal of Organic Chemistry. 17, p. 3513-3522 10 p.

Research output: Contribution to journalArticle

Circular Dichroism
dichroism
Agglomeration
Peptides
polypeptides
2 Citations (Scopus)

Helix compactness and stability: Electron structure calculations of conformer dependent thermodynamic functions

Jákli, I., Csizmadia, I., Fejer, S. N., Farkas, O., Viskolcz, B., Knak Jensen, S. J. & Perczel, A., Mar 20 2013, In : Chemical Physics Letters. 563, p. 80-87 8 p.

Research output: Contribution to journalArticle

void ratio
helices
Thermodynamics
Amino Acids
thermodynamics
9 Citations (Scopus)

Penetratin and derivatives acting as antibacterial agents

Garro, A. D., Olivella, M. S., Bombasaro, J. A., Lima, B., Tapia, A., Feresin, G., Perczel, A., Somlai, C., Penke, B., López Cascales, J., Rodríguez, A. M. & Enriz, R. D., Aug 2013, In : Chemical Biology and Drug Design. 82, 2, p. 167-177 11 p.

Research output: Contribution to journalArticle

Gram-Positive Bacteria
Trifluoroethanol
Anti-Bacterial Agents
Derivatives
Peptides
37 Citations (Scopus)

Structural insights into the Trp-cage folding intermediate formation

Rovõ, P., Stráner, P., Láng, A., Bartha, I., Huszár, K., Nyitray, L. & Perczel, A., Feb 18 2013, In : Chemistry - A European Journal. 19, 8, p. 2628-2640 13 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance
Proteins
Protein folding
Chemical shift
Deconvolution
2012
19 Citations (Scopus)

Charged single alpha-helices in proteomes revealed by a consensus prediction approach

Gáspári, Z., Süveges, D., Perczel, A., Nyitray, L. & Tóth, G., Apr 2012, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1824, 4, p. 637-646 10 p.

Research output: Contribution to journalArticle

Proteome
Proteins
Symbiosis
Conservation
Biological Phenomena
10 Citations (Scopus)

Estimating intrinsic structural preferences of de novo emerging random-sequence proteins: Is aggregation the main bottleneck?

Ángyán, A. F., Perczel, A. & Gáspári, Z., Jul 30 2012, In : FEBS Letters. 586, 16, p. 2468-2472 5 p.

Research output: Contribution to journalArticle

Agglomeration
Base Composition
Proteins
Crowns
Nucleotides
4 Citations (Scopus)

Exploiting diverse stereochemistry of b-amino acids: Toward a rational design of sheet-forming b-peptide systems

Pohl, G., Beke-Somfai, T., Csizmadia, I. & Perczel, A., Aug 2012, In : Amino Acids. 43, 2, p. 735-749 15 p.

Research output: Contribution to journalArticle

Stereochemistry
Chirality
Amino Acids
Peptides
Nanotubes
21 Citations (Scopus)

Secondary structure of short β-peptides as the chiral expression of monomeric building units: A rational and predictive model

Gorrea, E., Pohl, G., Nolis, P., Celis, S., Burusco, K. K., Branchadell, V., Perczel, A. & Ortuño, R. M., Nov 2 2012, In : Journal of Organic Chemistry. 77, 21, p. 9795-9806 12 p.

Research output: Contribution to journalArticle

Oligopeptides
Chirality
Cyclobutanes
Peptides
Biopolymers
5 Citations (Scopus)

The role of entropy in initializing the aggregation of peptides: A first principle study on oligopeptide oligomerization

Pohl, G., Jákli, I., Csizmadia, I., Papp, D., Matías, G. F. & Perczel, A., Jan 28 2012, In : Physical Chemistry Chemical Physics. 14, 4, p. 1507-1516 10 p.

Research output: Contribution to journalArticle

Oligopeptides
Oligomerization
peptides
Entropy
Agglomeration
7 Citations (Scopus)
Potential energy surfaces
topology
Visualization
potential energy
Topology
2011
28 Citations (Scopus)

Cooperativity network of Trp-cage miniproteins: Probing salt-bridges

Rovó, P., Farkas, V., Hegyi, O., Szolomájer-Csikós, O., Tóth, G. & Perczel, A., Sep 2011, In : Journal of Peptide Science. 17, 9, p. 610-619 10 p.

Research output: Contribution to journalArticle

Salts
Dichroism
Circular Dichroism
Static Electricity
Electrostatics
21 Citations (Scopus)

Disordered TPPP/p25 binds GTP and displays Mg2+-dependent GTPase activity

Zotter, Á., Bodor, A., Oláh, J., Hlavanda, E., Orosz, F., Perczel, A. & Ovádi, J., Mar 9 2011, In : FEBS Letters. 585, 5, p. 803-808 6 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Tubulin
Guanosine Triphosphate
Polymerization
Physiological Phenomena
26 Citations (Scopus)

Full backbone assignment and dynamics of the intrinsically disordered dehydrin ERD14

Ágoston, B. S., Kovács, D., Tompa, P. & Perczel, A., 2011, In : Biomolecular NMR Assignments. 5, 2, p. 189-193 5 p.

Research output: Contribution to journalArticle

Dehydration
Nuclear magnetic resonance
Intrinsically Disordered Proteins
Chemical shift
Heat-Shock Proteins
20 Citations (Scopus)

Hyperfine-shifted 13C resonance assignments in an iron-sulfur protein with quantum chemical verification: Aliphatic C-H⋯S 3-center-4-electron interactions

Westler, W. M., Lin, I. J., Perczel, A., Weinhold, F. & Markley, J. L., Feb 9 2011, In : Journal of the American Chemical Society. 133, 5, p. 1310-1316 7 p.

Research output: Contribution to journalArticle

Iron-Sulfur Proteins
Sulfur
Electrons
Iron
Proteins