• 6722 Citations
  • 40 h-Index
19972020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 6722 Citations
  • 40 h-Index
  • 68 Article
  • 13 Review article
  • 2 Editorial
Filter
Article

What is the future of targeted therapy in rheumatology: Biologics or small molecules?

Mócsai, A., Kovács, L. & Gergely, P., Mar 13 2014, In : BMC Medicine. 12, 1, 43.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Urine/plasma neutrophil gelatinase associated lipocalin ratio is a sensitive and specific marker of subclinical acute kidney injury in mice

Kaucsár, T., Godó, M., Révész, C., Kovács, M., Mócsai, A., Kiss, N., Albert, M., Krenács, T., Szénási, G. & Hamar, P., Jan 1 2016, In : PloS one. 11, 1, 0148043.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Tyrosine kinase inhibitors for the treatment of rheumatoid arthritis

Gomez-Puerta, J. A. & Mócsai, A., Jun 14 2013, In : Current topics in medicinal chemistry. 13, 6, p. 760-773 14 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

TRPA1 ion channel determines beneficial and detrimental effects of GYY4137 in murine serum-transfer arthritis

Bátai, I. Z., Sár, C. P., Horváth, Á., Borbély, É., Bölcskei, K., Kemény, Á., Sándor, Z., Nemes, B., Helyes, Z., Perkecz, A., Mócsai, A., Pozsgai, G. & Pintér, E., Jan 1 2019, In : Frontiers in Pharmacology. 10, 964.

Research output: Contribution to journalArticle

Open Access

The Yin and Yang of tyrosine kinase inhibition during experimental polymicrobial sepsis

Gonçalves-de-Albuquerque, C. F., Rohwedder, I., Silva, A. R., Ferreira, A. S., Kurz, A. R. M., Cougoule, C., Klapproth, S., Eggersmann, T., Silva, J. D., de Oliveira, G. P., Capelozzi, V. L., Schlesinger, G. G., Costa, E. R., Elias Estrela Marins, R. D. C., Mócsai, A., Maridonneau-Parini, I., Walzog, B., Rocco, P. R. M., Sperandio, M. & de Castro-Faria-Neto, H. C., Apr 30 2018, In : Frontiers in immunology. 9, APR, 901.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for β2 integrin (CD11/CD18)-mediated neutrophil migration

Schymeinsky, J., Sindrilaru, A., Frommhold, D., Sperandio, M., Gerstl, R., Then, C., Mócsai, A., Scharffetter-Kochanek, K. & Walzog, B., Dec 1 2006, In : Blood. 108, 12, p. 3919-3927 9 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

The Syk Tyrosine Kinase Is Required for Skin Inflammation in an In Vivo Mouse Model of Epidermolysis Bullosa Acquisita

Németh, T., Virtic, O., Sitaru, C. & Mócsai, A., Oct 2017, In : Journal of Investigative Dermatology. 137, 10, p. 2131-2139 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

Kova´cs, M., Ne´meth, T., Jakus, Z., Sitaru, C., Simon, E., Futosi, K., Botz, B., Helyes, Z., Lowell, C. A. & Mo´csai, A., Jan 1 2014, In : Journal of Experimental Medicine. 211, 10, p. 1993-2011 19 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

The role of neutrophils in autoimmune diseases

Németh, T. & Mócsai, A., Mar 30 2012, In : Immunology letters. 143, 1, p. 9-19 11 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)

The phosphoinositide 3-kinase isoform pi3kβ regulates osteoclast-mediated bone resorption in humans and mice

Györi, D., Csete, D., Benkö, S., Kulkarni, S., Mandl, P., Dobõ-Nagy, C., Vanhaesebroeck, B., Stephens, L., Hawkins, P. T. & Mõcsai, A., Aug 2014, In : Arthritis and Rheumatology. 66, 8, p. 2210-2221 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase

Mócsai, A., Humphrey, M. B., Van Ziffle, J. A. G., Hu, Y., Burghardt, A., Spusta, S. C., Majumdar, S., Lanier, L. L., Lowell, C. A. & Nakamura, M. C., Apr 20 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 16, p. 6158-6163 6 p.

Research output: Contribution to journalArticle

347 Citations (Scopus)

The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology

Oliveira, G. P., Silva, J. D., Marques, P. S., Gonçalves-De-Albuquerque, C. F., Santos, H. L., Vascocellos, A. P., Takiya, C. M., Morales, M. M., Pelosi, P., Mócsai, A., De Castro-Faria-Neto, H. C. & Rocco, P. R. M., Jan 1 2015, In : Cellular Physiology and Biochemistry. 36, 4, p. 1644-1658 15 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
56 Citations (Scopus)

Targeting vascular endothelial growth factor receptor 2 and protein kinase D1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro

Varga, A., Gyulavári, P., Greff, Z., Futosi, K., Németh, T., Simon-Szabó, L., Kerekes, K., Szántai-Kis, C., Brauswetter, D., Kokas, M., Borbély, G., Erdei, A., Mócsai, A., Kéri, G. & Vántus, T., Apr 14 2015, In : PloS one. 10, 4, e0124234.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Gross, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V., Mocsai, A., Tschopp, J. & Ruland, J., May 21 2009, In : Nature. 459, 7245, p. 433-436 4 p.

Research output: Contribution to journalArticle

579 Citations (Scopus)

Syk is required for integrin signaling in neutrophils

Mócsai, A., Zhou, M., Meng, F., Tybulewicz, V. L. & Lowell, C. A., Jan 1 2002, In : Immunity. 16, 4, p. 547-558 12 p.

Research output: Contribution to journalArticle

311 Citations (Scopus)

Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo

Frommhold, D., Mannigel, I., Schymeinsky, J., Mocsai, A., Poeschl, J., Walzog, B. & Sperandio, M., Nov 28 2007, In : BMC Immunology. 8, 31.

Research output: Contribution to journalArticle

47 Citations (Scopus)

SLP-76 regulates Fcγ receptor and integrin signaling in neutrophils

Newbrough, S. A., Mocsai, A., Clemens, R. A., Wu, J. N., Silverman, M. A., Singer, A. L., Lowell, C. A. & Koretzky, G. A., Nov 2003, In : Immunity. 19, 5, p. 761-769 9 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading

Chen, H., Mocsai, A., Zhang, H., Ding, R. X., Morisaki, J. H., White, M., Rothfork, J. M., Heiser, P., Colucci-Guyon, E., Lowell, C. A., Gresham, H. D., Allen, P. M. & Brown, E. J., Jul 1 2003, In : Immunity. 19, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Resting murine neutrophils express functional α4 integrins that signal through Src family kinases

Pereira, S., Zhou, M., Mócsai, A. & Lowell, C., Mar 15 2001, In : Journal of Immunology. 166, 6, p. 4115-4123 9 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
33 Citations (Scopus)

Research update for articles published in EJCI in 2012

Dullaart, R. P. F., Al-Daghri, N. M., Ashina, M., Bouzas-Mosquera, A., Brunetti, N. D., Buechler, C., Chen, H. S., Corrales, J. J., D'Archivio, M., Cas, A. D., Pino, G. G., Gómez-Abril, S. A., Gyori, D., Haslacher, H., Herder, C., Kerstens, M. N., Koutsilieris, M., Lombardi, C., Lupattelli, G., Mócsai, A. & 26 others, Msaouel, P., Orfao, A., Ormazabal, P., Pacher, R., Perkmann, T., Peteiro, J., Plischke, M., Reynaert, N. L., Ricci, M. A., Robles, N. R., Rocha, M., Rutten, E. P. A., Sabico, S., Santamaria, F., Santoro, F., Schmid, A., Schmidt, M., Schytz, H. W., Shyu, K. G., Tada, H., Thorand, B., Valerio, G., Vesely, D. L., Wu, T. E., Yamagishi, M. & Yeh, Y. T., Oct 1 2014, In : European Journal of Clinical Investigation. 44, 10, p. 1010-1023 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways

Futosi, K., Fodor, S. & Mócsai, A., Dec 1 2013, In : International Immunopharmacology. 17, 4, p. 1185-1197 13 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Repercussion of megakaryocyte-specific Gata1 Loss on megakaryopoiesis and the hematopoietic precursor compartment

Meinders, M., Hoogenboezem, M., Scheenstra, M. R., De Cuyper, I. M., Papadopoulos, P., Németh, T., Mócsai, A., Van Den Berg, T. K., Kuijpers, T. W. & Gutiérrez, L., May 1 2016, In : PloS one. 11, 5, e0154342.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk

Abtahian, F., Guerriero, A., Sebzda, E., Lu, M. M., Zhou, R., Mocsai, A., Myers, E. E., Huang, B., Jackson, D. G., Ferrari, V. A., Tybulewicz, V., Lowell, C. A., Lepore, J. J., Koretzky, G. A. & Kahn, M. L., Jan 10 2003, In : Science. 299, 5604, p. 247-251 5 p.

Research output: Contribution to journalArticle

297 Citations (Scopus)

PI3Kβ plays a critical role in neutrophil activation by immune complexes

Kulkarni, S., Sitaru, C., Jakus, Z., Anderson, K. E., Damoulakis, G., Davidson, K., Hirose, M., Juss, J., Oxley, D., Chessa, T. A. M., Ramadani, F., Guillou, H., Segonds-Pichon, A., Fritsch, A., Jarvis, G. E., Okkenhaug, K., Ludwig, R., Zillikens, D., Mocsai, A., Vanhaesebroeck, B. & 2 others, Stephens, L. R. & Hawkins, P. T., Apr 12 2011, In : Science Signaling. 4, 168, ra23.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Phospholipase Cγ2 is required for basal but not oestrogen deficiency-induced bone resorption

Kertész, Z., Gyori, D., Körmendi, S., Fekete, T., Kis-Tóth, K., Jakus, Z., Schett, G., Rajnavölgyi, É., Dobó-Nagy, C. & Mócsai, A., Jan 1 2012, In : European Journal of Clinical Investigation. 42, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3

Gambardella, L., Anderson, K. E., Jakus, Z., Kovács, M., Voigt, S., Hawkins, P. T., Stephens, L., Mócsai, A. & Vermeren, S., Jan 1 2013, In : Journal of Immunology. 190, 1, p. 381-391 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases

Wannick, M., Bezdek, S., Guillen, N., Thieme, M., Meshrkey, F., Mousavi, S., Seeling, M., Nimmerjahn, F., Mócsai, A., Zillikens, D., Sezin, T. & Sadik, C. D., Dec 1 2018, In : Pharmacology Research and Perspectives. 6, 6, e00438.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Optimization of important early ADME(T) parameters of NADPH oxidase-4 inhibitor molecules

Borbély, G., Huszár, M., Varga, A., Futosi, K., Mócsai, A., Orfi, L., Idei, M., Mandl, J., Kéri, G. & Vántus, T., Mar 2012, In : Medicinal Chemistry. 8, 2, p. 174-181 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Nicotinic acetylcholine receptors modulate osteoclastogenesis

Mandl, P., Hayer, S., Karonitsch, T., Scholze, P., Gyori, D., Sykoutri, D., Blüml, S., Mócsai, A., Poór, G., Huck, S., Smolen, J. S. & Redlich, K., Mar 12 2016, In : Arthritis Research and Therapy. 18, 1, 63.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo

Németh, T., Futosi, K., Sitaru, C., Ruland, J. & Mócsai, A., Apr 1 2016, In : Nature Communications. 7, 11004.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity

Weber, F. C., Németh, T., Csepregi, J. Z., Dudeck, A., Roers, A., Ozsvári, B., Oswald, E., Puskás, L. G., Jakob, T., Mócsai, A. & Martin, S. F., Jan 12 2015, In : Journal of Experimental Medicine. 212, 1, p. 15-22 8 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage

Schwab, L., Goroncy, L., Palaniyandi, S., Gautam, S., Triantafyllopoulou, A., Mocsai, A., Reichardt, W., Karlsson, F. J., Radhakrishnan, S. V., Hanke, K., Schmitt-Graeff, A., Freudenberg, M., Von Loewenich, F. D., Wolf, P., Leonhardt, F., Baxan, N., Pfeifer, D., Schmah, O., Schönle, A., Martin, S. F. & 9 others, Mertelsmann, R., Duyster, J., Finke, J., Prinz, M., Henneke, P., Häcker, H., Hildebrandt, G. C., Häcker, G. & Zeiser, R., Jun 2014, In : Nature medicine. 20, 6, p. 648-654 7 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)

Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: Generation and analysis of a novel null mutation in mice

Németh, T., Futosi, K., Hably, C., Brouns, M. R., Jakob, S. M., Kovács, M., Kertész, Z., Walzog, B., Settleman, J. & Mócsai, A., Sep 1 2010, In : Journal of Immunology. 185, 5, p. 3064-3075 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Neutrophil cell surface receptors and their intracellular signal transduction pathways

Futosi, K., Fodor, S. & Mócsai, A., Sep 17 2013, In : International Immunopharmacology. 17, 3, p. 638-650 13 p.

Research output: Contribution to journalArticle

237 Citations (Scopus)

Myeloid-specific deletion of Mcl-1 yields severely neutropenic mice that survive and breed in homozygous form

Csepregi, J. Z., Orosz, A., Zajta, E., Kasa, O., Nemeth, T., Simon, E., Fodor, S., Csonka, K., Baratki, B. L., Kovesdi, D., He, Y. W., Gacser, A. & Mocsai, A., Dec 15 2018, In : Journal of Immunology. 201, 12, p. 3793-3803 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

MASP-1 induces a unique cytokine pattern in endothelial cells: A novel link between complement system and neutrophil granulocytes

Jani, P. K., Kajdácsi, E., Megyeri, M., Dobó, J., Doleschall, Z., Futosi, K., Tímár, C. I., Mócsai, A., Makó, V., Gál, P. & Cervenak, L., Jan 29 2014, In : PloS one. 9, 1, e87104.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Lineage-specific analysis of Syk function in autoantibody-induced arthritis

Németh, T., Futosi, K., Szilveszter, K., Vilinovszki, O., Kiss-Pápai, L. & Mócsai, A., Mar 19 2018, In : Frontiers in Immunology. 9, MAR, 555.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Lack of Galanin 3 Receptor Aggravates Murine Autoimmune Arthritis

Botz, B., Kemény, Á., Brunner, S. M., Locker, F., Csepregi, J., Mócsai, A., Pintér, E., McDougall, J. J., Kofler, B. & Helyes, Z., Jun 1 2016, In : Journal of Molecular Neuroscience. 59, 2, p. 260-269 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
Open Access
237 Citations (Scopus)

ITAM-based signaling beyond the adaptive immune response

Fodor, S., Jakus, Z. & Mócsai, A., Apr 15 2006, In : Immunology letters. 104, 1-2, p. 29-37 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

Mócsai, A., Abram, C. L., Jakus, Z., Hu, Y., Lanier, L. L. & Lowell, C. A., Dec 1 2006, In : Nature Immunology. 7, 12, p. 1326-1333 8 p.

Research output: Contribution to journalArticle

250 Citations (Scopus)

Importance of Fc Receptor γ-Chain ITAM Tyrosines in Neutrophil Activation and in vivo Autoimmune Arthritis

Németh, T., Futosi, K., Szabó, M., Aradi, P., Saito, T., Mócsai, A. & Jakus, Z., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access

Hydrophobic cyanine dye-doped micelles for optical in vivo imaging of plasma leakage and vascular disruption

Botz, B., Bölcskei, K., Kemény, Á., Sándor, Z., Tékus, V., Sétáló, G., Csepregi, J., Mócsai, A., Pintér, E., Kollár, L. & Helyes, Z., Jan 1 2015, In : Journal of biomedical optics. 20, 1, 016022.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Hematopoietic or osteoclast-specific deletion of Syk leads to increased bone mass in experimental mice

Csete, D., Simon, E., Alatshan, A., Aradi, P., Dobó-Nagy, C., Jakus, Z., Benko, S., Gyori, D. S. & Mócsai, A., Jan 1 2019, In : Frontiers in immunology. 10, APR, 937.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility

Medina, I., Cougoule, C., Drechsler, M., Bermudez, B., Koenen, R. R., Sluimer, J., Wolfs, I., Döring, Y., Herias, V., Gijbels, M., Bot, I., De Jager, S. C. A., Weber, C., Cleutjens, J., Van Berkel, T. J. C., Sikkink, K. J., Mócsai, A., Maridonneau-Parini, I., Soehnlein, O. & Biessen, E. A. L., Aug 11 2015, In : Circulation. 132, 6, p. 490-501 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells

Mócsai, A., Zhang, H., Jakus, Z., Kitaura, J., Kawakami, T. & Lowell, C. A., May 15 2003, In : Blood. 101, 10, p. 4155-4163 9 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Genetic deficiency of Syk protects mice from autoantibody-induced arthritis

Jakus, Z., Simon, E., Balázs, B. & Mócsai, A., Jul 1 2010, In : Arthritis and rheumatism. 62, 7, p. 1899-1910 12 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Extracellular vesicles regulate the human osteoclastogenesis: divergent roles in discrete inflammatory arthropathies

Marton, N., Kovács, O. T., Baricza, E., Kittel, A., Győri, D., Mócsai, A., Meier, F. M. P., Goodyear, C. S., McInnes, I. B., Búzás, E. & Nagy, G., Oct 1 2017, In : Cellular and Molecular Life Sciences. 74, 19, p. 3599-3611 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)