• 6667 Citations
  • 40 h-Index
19972019

Research output per year

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Research Output

  • 6667 Citations
  • 40 h-Index
  • 67 Article
  • 12 Review article
  • 2 Editorial
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Article

Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage

Németh, B., Doczi, J., Csete, D., Kacso, G., Ravasz, D., Adams, D., Kiss, G., Nagy, A. M., Horvath, G., Tretter, L., Mócsai, A., Csépányi-Kömi, R., Iordanov, I., Adam-Vizi, V. & Chinopoulos, C., Jan 1 2016, In : FASEB Journal. 30, 1, p. 286-300 15 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck

Mócsai, A., Ligeti, E., Lowell, C. A. & Berton, G., Jan 15 1999, In : Journal of Immunology. 162, 2, p. 1120-1126 7 p.

Research output: Contribution to journalArticle

185 Citations (Scopus)

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FclRγ-Syk- Card9-dependent innate immune activation

Werninghaus, K., Babiak, A., Groß, O., Hölscher, C., Dietrich, H., Agger, E. M., Mages, J., Mocsai, A., Schoenen, H., Finger, K., Nimmerjahn, F., Brown, G. D., Kirschning, C., Heit, A., Andersen, P., Wagner, H., Ruland, J. & Lang, R., Jan 16 2009, In : Journal of Experimental Medicine. 206, 1, p. 89-97 9 p.

Research output: Contribution to journalArticle

207 Citations (Scopus)

A fundamental role of mAbp1 in neutrophils: Impact on β2 integrin-mediated phagocytosis and adhesion in vivo

Schymeinsky, J., Gerstl, R., Mannigel, I., Niedung, K., Frommhold, D., Panthel, K., Heesemann, J., Sixt, M., Quast, T., Kolanus, W., Mocsai, A., Wienands, J., Sperandio, M. & Walzog, B., Nov 5 2009, In : Blood. 114, 19, p. 4209-4220 12 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
8 Citations (Scopus)

Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis

Borbély, É., Botz, B., Bölcskei, K., Kenyér, T., Kereskai, L., Kiss, T., Szolcsányi, J., Pintér, E., Csepregi, J. Z., Mócsai, A. & Helyes, Z., Mar 1 2015, In : Brain, Behavior, and Immunity. 45, p. 50-59 10 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae

Boyle, K. B., Gyori, D., Sindrilaru, A., Scharffetter-Kochanek, K., Taylor, P. R., Mócsai, A., Stephens, L. R. & Hawkins, P. T., Mar 1 2011, In : Journal of Immunology. 186, 5, p. 2978-2989 12 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Contribution of phopholipase D and a brefeldin A-sensitive ARF to chemoattractant-induced superoxide production and secretion of human neutrophils

Káldi, K., Szeberényi, J., Rada, B. K., Kovács, P., Geiszt, M., Mócsai, A. & Ligeti, E., Apr 1 2002, In : Journal of Leukocyte Biology. 71, 4, p. 695-700 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton

Obergfell, A., Eto, K., Mocsai, A., Buensuceso, C., Moores, S. L., Brugge, J. S., Lowell, C. A. & Shattil, S. J., Apr 15 2002, In : Journal of Cell Biology. 157, 2, p. 265-275 11 p.

Research output: Contribution to journalArticle

323 Citations (Scopus)

Critical but overlapping role of FcγRIII and FcγRIV in activation of murine neutrophils by immobilized immune complexes

Jakus, Z., Németh, T., Verbeek, J. S. & Mócsai, A., Jan 1 2008, In : Journal of Immunology. 180, 1, p. 618-629 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

Jakus, Z., Simon, E., Frommhold, D., Sperandio, M. & Mócsai, A., Mar 16 2009, In : Journal of Experimental Medicine. 206, 3, p. 577-593 17 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Dasatinib inhibits proinflammatory functions of mature human neutrophils

Futosi, K., Németh, T., Pick, R., Vántus, T., Walzog, B. & Mócsai, A., May 24 2012, In : Blood. 119, 21, p. 4981-4991 11 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
43 Citations (Scopus)

Differential regulatory role of pituitary adenylate cyclase-activating polypeptide in the serum-transfer arthritis model

Botz, B., Bölcskei, K., Kereskai, L., Kovács, M., Németh, T., Szigeti, K., Horváth, I., Máthé, D., Kovács, N., Hashimoto, H., Reglödi, D., Szolcsányi, J., Pintér, E., Mõcsai, A. & Helyes, Z., Oct 1 2014, In : Arthritis and Rheumatology. 66, 10, p. 2739-2750 12 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
32 Citations (Scopus)

Erratum: Targeting vascular endothelial growth factor receptor 2 and protein kinase d1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro (PLoS ONE)

Varga, A., Gyulavári, P., Greff, Z., Futosi, K., Nemeth, T., Simon-Szabó, L., Kerekes, K., Szántai-Kis, C., Brauswetter, D., Kokas, M., Borbely, G., Erdei, A., Mócsai, A., Kéri, G. & Vántus, T., Dec 1 2015, In : PLoS One. 10, 12, e0144792.

Research output: Contribution to journalArticle

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcεRI

Kitaura, J., Song, J., Tsai, M., Asai, K., Maeda-Yamamoto, M., Mocsai, A., Kawakami, Y., Liu, F. T., Lowell, C. A., Barisas, B. G., Galli, S. J. & Kawakami, T., Oct 28 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 22, p. 12911-12916 6 p.

Research output: Contribution to journalArticle

217 Citations (Scopus)

Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps

Kienhöfer, D., Hahn, J., Stoof, J., Csepregi, J. Z., Reinwald, C., Urbonaviciute, V., Johnsson, C., Maueröder, C., Podolska, M. J., Biermann, M. H., Leppkes, M., Harrer, T., Hultqvist, M., Olofsson, P., Munoz, L. E., Mócsai, A., Herrmann, M., Schett, G., Holmdahl, R. & Hoffmann, M. H., May 18 2017, In : JCI insight. 2, 10

Research output: Contribution to journalArticle

Open Access
42 Citations (Scopus)

Extracellular vesicles regulate the human osteoclastogenesis: divergent roles in discrete inflammatory arthropathies

Marton, N., Kovács, O. T., Baricza, E., Kittel, A., Győri, D., Mócsai, A., Meier, F. M. P., Goodyear, C. S., McInnes, I. B., Búzás, E. & Nagy, G., Oct 1 2017, In : Cellular and Molecular Life Sciences. 74, 19, p. 3599-3611 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Genetic deficiency of Syk protects mice from autoantibody-induced arthritis

Jakus, Z., Simon, E., Balázs, B. & Mócsai, A., Jul 1 2010, In : Arthritis and rheumatism. 62, 7, p. 1899-1910 12 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells

Mócsai, A., Zhang, H., Jakus, Z., Kitaura, J., Kawakami, T. & Lowell, C. A., May 15 2003, In : Blood. 101, 10, p. 4155-4163 9 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility

Medina, I., Cougoule, C., Drechsler, M., Bermudez, B., Koenen, R. R., Sluimer, J., Wolfs, I., Döring, Y., Herias, V., Gijbels, M., Bot, I., De Jager, S. C. A., Weber, C., Cleutjens, J., Van Berkel, T. J. C., Sikkink, K. J., Mócsai, A., Maridonneau-Parini, I., Soehnlein, O. & Biessen, E. A. L., Aug 11 2015, In : Circulation. 132, 6, p. 490-501 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Hematopoietic or osteoclast-specific deletion of Syk leads to increased bone mass in experimental mice

Csete, D., Simon, E., Alatshan, A., Aradi, P., Dobó-Nagy, C., Jakus, Z., Benko, S., Gyori, D. S. & Mócsai, A., Jan 1 2019, In : Frontiers in immunology. 10, APR, 937.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Importance of Fc Receptor γ-Chain ITAM Tyrosines in Neutrophil Activation and in vivo Autoimmune Arthritis

Németh, T., Futosi, K., Szabó, M., Aradi, P., Saito, T., Mócsai, A. & Jakus, Z., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

Mócsai, A., Abram, C. L., Jakus, Z., Hu, Y., Lanier, L. L. & Lowell, C. A., Dec 1 2006, In : Nature Immunology. 7, 12, p. 1326-1333 8 p.

Research output: Contribution to journalArticle

249 Citations (Scopus)

ITAM-based signaling beyond the adaptive immune response

Fodor, S., Jakus, Z. & Mócsai, A., Apr 15 2006, In : Immunology letters. 104, 1-2, p. 29-37 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)
Open Access
237 Citations (Scopus)

Lack of Galanin 3 Receptor Aggravates Murine Autoimmune Arthritis

Botz, B., Kemény, Á., Brunner, S. M., Locker, F., Csepregi, J., Mócsai, A., Pintér, E., McDougall, J. J., Kofler, B. & Helyes, Z., Jun 1 2016, In : Journal of Molecular Neuroscience. 59, 2, p. 260-269 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Lineage-specific analysis of Syk function in autoantibody-induced arthritis

Németh, T., Futosi, K., Szilveszter, K., Vilinovszki, O., Kiss-Pápai, L. & Mócsai, A., Mar 19 2018, In : Frontiers in Immunology. 9, MAR, 555.

Research output: Contribution to journalArticle

5 Citations (Scopus)

MASP-1 induces a unique cytokine pattern in endothelial cells: A novel link between complement system and neutrophil granulocytes

Jani, P. K., Kajdácsi, E., Megyeri, M., Dobó, J., Doleschall, Z., Futosi, K., Tímár, C. I., Mócsai, A., Makó, V., Gál, P. & Cervenak, L., Jan 29 2014, In : PloS one. 9, 1, e87104.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Myeloid-specific deletion of Mcl-1 yields severely neutropenic mice that survive and breed in homozygous form

Csepregi, J. Z., Orosz, A., Zajta, E., Kasa, O., Nemeth, T., Simon, E., Fodor, S., Csonka, K., Baratki, B. L., Kovesdi, D., He, Y. W., Gacser, A. & Mocsai, A., Dec 15 2018, In : Journal of Immunology. 201, 12, p. 3793-3803 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Neutrophil cell surface receptors and their intracellular signal transduction pathways

Futosi, K., Fodor, S. & Mócsai, A., Sep 17 2013, In : International Immunopharmacology. 17, 3, p. 638-650 13 p.

Research output: Contribution to journalArticle

233 Citations (Scopus)

Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: Generation and analysis of a novel null mutation in mice

Németh, T., Futosi, K., Hably, C., Brouns, M. R., Jakob, S. M., Kovács, M., Kertész, Z., Walzog, B., Settleman, J. & Mócsai, A., Sep 1 2010, In : Journal of Immunology. 185, 5, p. 3064-3075 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage

Schwab, L., Goroncy, L., Palaniyandi, S., Gautam, S., Triantafyllopoulou, A., Mocsai, A., Reichardt, W., Karlsson, F. J., Radhakrishnan, S. V., Hanke, K., Schmitt-Graeff, A., Freudenberg, M., Von Loewenich, F. D., Wolf, P., Leonhardt, F., Baxan, N., Pfeifer, D., Schmah, O., Schönle, A., Martin, S. F. & 9 others, Mertelsmann, R., Duyster, J., Finke, J., Prinz, M., Henneke, P., Häcker, H., Hildebrandt, G. C., Häcker, G. & Zeiser, R., Jun 2014, In : Nature medicine. 20, 6, p. 648-654 7 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity

Weber, F. C., Németh, T., Csepregi, J. Z., Dudeck, A., Roers, A., Ozsvári, B., Oswald, E., Puskás, L. G., Jakob, T., Mócsai, A. & Martin, S. F., Jan 1 2015, In : Journal of Experimental Medicine. 212, 1, p. 15-22 8 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo

Németh, T., Futosi, K., Sitaru, C., Ruland, J. & Mócsai, A., Apr 1 2016, In : Nature Communications. 7, 11004.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Nicotinic acetylcholine receptors modulate osteoclastogenesis

Mandl, P., Hayer, S., Karonitsch, T., Scholze, P., Gyori, D., Sykoutri, D., Blüml, S., Mócsai, A., Poór, G., Huck, S., Smolen, J. S. & Redlich, K., Mar 12 2016, In : Arthritis Research and Therapy. 18, 1, 63.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Optimization of important early ADME(T) parameters of NADPH oxidase-4 inhibitor molecules

Borbély, G., Huszár, M., Varga, A., Futosi, K., Mócsai, A., Orfi, L., Idei, M., Mandl, J., Kéri, G. & Vántus, T., Mar 2012, In : Medicinal Chemistry. 8, 2, p. 174-181 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases

Wannick, M., Bezdek, S., Guillen, N., Thieme, M., Meshrkey, F., Mousavi, S., Seeling, M., Nimmerjahn, F., Mócsai, A., Zillikens, D., Sezin, T. & Sadik, C. D., Dec 1 2018, In : Pharmacology Research and Perspectives. 6, 6, e00438.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3

Gambardella, L., Anderson, K. E., Jakus, Z., Kovács, M., Voigt, S., Hawkins, P. T., Stephens, L., Mócsai, A. & Vermeren, S., Jan 1 2013, In : Journal of Immunology. 190, 1, p. 381-391 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Phospholipase Cγ2 is required for basal but not oestrogen deficiency-induced bone resorption

Kertész, Z., Gyori, D., Körmendi, S., Fekete, T., Kis-Tóth, K., Jakus, Z., Schett, G., Rajnavölgyi, É., Dobó-Nagy, C. & Mócsai, A., Jan 1 2012, In : European Journal of Clinical Investigation. 42, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

PI3Kβ plays a critical role in neutrophil activation by immune complexes

Kulkarni, S., Sitaru, C., Jakus, Z., Anderson, K. E., Damoulakis, G., Davidson, K., Hirose, M., Juss, J., Oxley, D., Chessa, T. A. M., Ramadani, F., Guillou, H., Segonds-Pichon, A., Fritsch, A., Jarvis, G. E., Okkenhaug, K., Ludwig, R., Zillikens, D., Mocsai, A., Vanhaesebroeck, B. & 2 others, Stephens, L. R. & Hawkins, P. T., Apr 12 2011, In : Science Signaling. 4, 168, ra23.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk

Abtahian, F., Guerriero, A., Sebzda, E., Lu, M. M., Zhou, R., Mocsai, A., Myers, E. E., Huang, B., Jackson, D. G., Ferrari, V. A., Tybulewicz, V., Lowell, C. A., Lepore, J. J., Koretzky, G. A. & Kahn, M. L., Jan 10 2003, In : Science. 299, 5604, p. 247-251 5 p.

Research output: Contribution to journalArticle

297 Citations (Scopus)

Repercussion of megakaryocyte-specific Gata1 Loss on megakaryopoiesis and the hematopoietic precursor compartment

Meinders, M., Hoogenboezem, M., Scheenstra, M. R., De Cuyper, I. M., Papadopoulos, P., Németh, T., Mócsai, A., Van Den Berg, T. K., Kuijpers, T. W. & Gutiérrez, L., May 1 2016, In : PloS one. 11, 5, e0154342.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways

Futosi, K., Fodor, S. & Mócsai, A., Dec 1 2013, In : International Immunopharmacology. 17, 4, p. 1185-1197 13 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Research update for articles published in EJCI in 2012

Dullaart, R. P. F., Al-Daghri, N. M., Ashina, M., Bouzas-Mosquera, A., Brunetti, N. D., Buechler, C., Chen, H. S., Corrales, J. J., D'Archivio, M., Cas, A. D., Pino, G. G., Gómez-Abril, S. A., Gyori, D., Haslacher, H., Herder, C., Kerstens, M. N., Koutsilieris, M., Lombardi, C., Lupattelli, G., Mócsai, A. & 26 others, Msaouel, P., Orfao, A., Ormazabal, P., Pacher, R., Perkmann, T., Peteiro, J., Plischke, M., Reynaert, N. L., Ricci, M. A., Robles, N. R., Rocha, M., Rutten, E. P. A., Sabico, S., Santamaria, F., Santoro, F., Schmid, A., Schmidt, M., Schytz, H. W., Shyu, K. G., Tada, H., Thorand, B., Valerio, G., Vesely, D. L., Wu, T. E., Yamagishi, M. & Yeh, Y. T., Oct 1 2014, In : European Journal of Clinical Investigation. 44, 10, p. 1010-1023 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
33 Citations (Scopus)

Resting murine neutrophils express functional α4 integrins that signal through Src family kinases

Pereira, S., Zhou, M., Mócsai, A. & Lowell, C., Mar 15 2001, In : Journal of Immunology. 166, 6, p. 4115-4123 9 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading

Chen, H., Mocsai, A., Zhang, H., Ding, R. X., Morisaki, J. H., White, M., Rothfork, J. M., Heiser, P., Colucci-Guyon, E., Lowell, C. A., Gresham, H. D., Allen, P. M. & Brown, E. J., Jul 1 2003, In : Immunity. 19, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

SLP-76 regulates Fcγ receptor and integrin signaling in neutrophils

Newbrough, S. A., Mocsai, A., Clemens, R. A., Wu, J. N., Silverman, M. A., Singer, A. L., Lowell, C. A. & Koretzky, G. A., Nov 2003, In : Immunity. 19, 5, p. 761-769 9 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)