• 6667 Citations
  • 40 h-Index
19972019

Research output per year

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Research Output

  • 6667 Citations
  • 40 h-Index
  • 67 Article
  • 12 Review article
  • 2 Editorial
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Article
1997
43 Citations (Scopus)
32 Citations (Scopus)
1999

Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck

Mócsai, A., Ligeti, E., Lowell, C. A. & Berton, G., Jan 15 1999, In : Journal of Immunology. 162, 2, p. 1120-1126 7 p.

Research output: Contribution to journalArticle

185 Citations (Scopus)
2000
Open Access
237 Citations (Scopus)
2001

Resting murine neutrophils express functional α4 integrins that signal through Src family kinases

Pereira, S., Zhou, M., Mócsai, A. & Lowell, C., Mar 15 2001, In : Journal of Immunology. 166, 6, p. 4115-4123 9 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2002

Contribution of phopholipase D and a brefeldin A-sensitive ARF to chemoattractant-induced superoxide production and secretion of human neutrophils

Káldi, K., Szeberényi, J., Rada, B. K., Kovács, P., Geiszt, M., Mócsai, A. & Ligeti, E., Apr 1 2002, In : Journal of Leukocyte Biology. 71, 4, p. 695-700 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton

Obergfell, A., Eto, K., Mocsai, A., Buensuceso, C., Moores, S. L., Brugge, J. S., Lowell, C. A. & Shattil, S. J., Apr 15 2002, In : Journal of Cell Biology. 157, 2, p. 265-275 11 p.

Research output: Contribution to journalArticle

323 Citations (Scopus)

Syk is required for integrin signaling in neutrophils

Mócsai, A., Zhou, M., Meng, F., Tybulewicz, V. L. & Lowell, C. A., Jan 1 2002, In : Immunity. 16, 4, p. 547-558 12 p.

Research output: Contribution to journalArticle

310 Citations (Scopus)
2003

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcεRI

Kitaura, J., Song, J., Tsai, M., Asai, K., Maeda-Yamamoto, M., Mocsai, A., Kawakami, Y., Liu, F. T., Lowell, C. A., Barisas, B. G., Galli, S. J. & Kawakami, T., Oct 28 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 22, p. 12911-12916 6 p.

Research output: Contribution to journalArticle

217 Citations (Scopus)

G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells

Mócsai, A., Zhang, H., Jakus, Z., Kitaura, J., Kawakami, T. & Lowell, C. A., May 15 2003, In : Blood. 101, 10, p. 4155-4163 9 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk

Abtahian, F., Guerriero, A., Sebzda, E., Lu, M. M., Zhou, R., Mocsai, A., Myers, E. E., Huang, B., Jackson, D. G., Ferrari, V. A., Tybulewicz, V., Lowell, C. A., Lepore, J. J., Koretzky, G. A. & Kahn, M. L., Jan 10 2003, In : Science. 299, 5604, p. 247-251 5 p.

Research output: Contribution to journalArticle

297 Citations (Scopus)

Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading

Chen, H., Mocsai, A., Zhang, H., Ding, R. X., Morisaki, J. H., White, M., Rothfork, J. M., Heiser, P., Colucci-Guyon, E., Lowell, C. A., Gresham, H. D., Allen, P. M. & Brown, E. J., Jul 1 2003, In : Immunity. 19, 1, p. 95-104 10 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

SLP-76 regulates Fcγ receptor and integrin signaling in neutrophils

Newbrough, S. A., Mocsai, A., Clemens, R. A., Wu, J. N., Silverman, M. A., Singer, A. L., Lowell, C. A. & Koretzky, G. A., Nov 2003, In : Immunity. 19, 5, p. 761-769 9 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
2004
33 Citations (Scopus)

The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase

Mócsai, A., Humphrey, M. B., Van Ziffle, J. A. G., Hu, Y., Burghardt, A., Spusta, S. C., Majumdar, S., Lanier, L. L., Lowell, C. A. & Nakamura, M. C., Apr 20 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 16, p. 6158-6163 6 p.

Research output: Contribution to journalArticle

346 Citations (Scopus)
2006

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

Mócsai, A., Abram, C. L., Jakus, Z., Hu, Y., Lanier, L. L. & Lowell, C. A., Dec 1 2006, In : Nature Immunology. 7, 12, p. 1326-1333 8 p.

Research output: Contribution to journalArticle

249 Citations (Scopus)

ITAM-based signaling beyond the adaptive immune response

Fodor, S., Jakus, Z. & Mócsai, A., Apr 15 2006, In : Immunology letters. 104, 1-2, p. 29-37 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for β2 integrin (CD11/CD18)-mediated neutrophil migration

Schymeinsky, J., Sindrilaru, A., Frommhold, D., Sperandio, M., Gerstl, R., Then, C., Mócsai, A., Scharffetter-Kochanek, K. & Walzog, B., Dec 1 2006, In : Blood. 108, 12, p. 3919-3927 9 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
2007

Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo

Frommhold, D., Mannigel, I., Schymeinsky, J., Mocsai, A., Poeschl, J., Walzog, B. & Sperandio, M., Nov 28 2007, In : BMC Immunology. 8, 31.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2008

Critical but overlapping role of FcγRIII and FcγRIV in activation of murine neutrophils by immobilized immune complexes

Jakus, Z., Németh, T., Verbeek, J. S. & Mócsai, A., Jan 1 2008, In : Journal of Immunology. 180, 1, p. 618-629 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2009

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FclRγ-Syk- Card9-dependent innate immune activation

Werninghaus, K., Babiak, A., Groß, O., Hölscher, C., Dietrich, H., Agger, E. M., Mages, J., Mocsai, A., Schoenen, H., Finger, K., Nimmerjahn, F., Brown, G. D., Kirschning, C., Heit, A., Andersen, P., Wagner, H., Ruland, J. & Lang, R., Jan 16 2009, In : Journal of Experimental Medicine. 206, 1, p. 89-97 9 p.

Research output: Contribution to journalArticle

207 Citations (Scopus)

A fundamental role of mAbp1 in neutrophils: Impact on β2 integrin-mediated phagocytosis and adhesion in vivo

Schymeinsky, J., Gerstl, R., Mannigel, I., Niedung, K., Frommhold, D., Panthel, K., Heesemann, J., Sixt, M., Quast, T., Kolanus, W., Mocsai, A., Wienands, J., Sperandio, M. & Walzog, B., Nov 5 2009, In : Blood. 114, 19, p. 4209-4220 12 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

Jakus, Z., Simon, E., Frommhold, D., Sperandio, M. & Mócsai, A., Mar 16 2009, In : Journal of Experimental Medicine. 206, 3, p. 577-593 17 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Gross, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V., Mocsai, A., Tschopp, J. & Ruland, J., May 21 2009, In : Nature. 459, 7245, p. 433-436 4 p.

Research output: Contribution to journalArticle

578 Citations (Scopus)
2010

Genetic deficiency of Syk protects mice from autoantibody-induced arthritis

Jakus, Z., Simon, E., Balázs, B. & Mócsai, A., Jul 1 2010, In : Arthritis and rheumatism. 62, 7, p. 1899-1910 12 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: Generation and analysis of a novel null mutation in mice

Németh, T., Futosi, K., Hably, C., Brouns, M. R., Jakob, S. M., Kovács, M., Kertész, Z., Walzog, B., Settleman, J. & Mócsai, A., Sep 1 2010, In : Journal of Immunology. 185, 5, p. 3064-3075 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2011

Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae

Boyle, K. B., Gyori, D., Sindrilaru, A., Scharffetter-Kochanek, K., Taylor, P. R., Mócsai, A., Stephens, L. R. & Hawkins, P. T., Mar 1 2011, In : Journal of Immunology. 186, 5, p. 2978-2989 12 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

PI3Kβ plays a critical role in neutrophil activation by immune complexes

Kulkarni, S., Sitaru, C., Jakus, Z., Anderson, K. E., Damoulakis, G., Davidson, K., Hirose, M., Juss, J., Oxley, D., Chessa, T. A. M., Ramadani, F., Guillou, H., Segonds-Pichon, A., Fritsch, A., Jarvis, G. E., Okkenhaug, K., Ludwig, R., Zillikens, D., Mocsai, A., Vanhaesebroeck, B. & 2 others, Stephens, L. R. & Hawkins, P. T., Apr 12 2011, In : Science Signaling. 4, 168, ra23.

Research output: Contribution to journalArticle

99 Citations (Scopus)
2012

Dasatinib inhibits proinflammatory functions of mature human neutrophils

Futosi, K., Németh, T., Pick, R., Vántus, T., Walzog, B. & Mócsai, A., May 24 2012, In : Blood. 119, 21, p. 4981-4991 11 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Optimization of important early ADME(T) parameters of NADPH oxidase-4 inhibitor molecules

Borbély, G., Huszár, M., Varga, A., Futosi, K., Mócsai, A., Orfi, L., Idei, M., Mandl, J., Kéri, G. & Vántus, T., Mar 2012, In : Medicinal Chemistry. 8, 2, p. 174-181 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Phospholipase Cγ2 is required for basal but not oestrogen deficiency-induced bone resorption

Kertész, Z., Gyori, D., Körmendi, S., Fekete, T., Kis-Tóth, K., Jakus, Z., Schett, G., Rajnavölgyi, É., Dobó-Nagy, C. & Mócsai, A., Jan 1 2012, In : European Journal of Clinical Investigation. 42, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

The role of neutrophils in autoimmune diseases

Németh, T. & Mócsai, A., Mar 30 2012, In : Immunology letters. 143, 1, p. 9-19 11 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)
2013

Neutrophil cell surface receptors and their intracellular signal transduction pathways

Futosi, K., Fodor, S. & Mócsai, A., Sep 17 2013, In : International Immunopharmacology. 17, 3, p. 638-650 13 p.

Research output: Contribution to journalArticle

233 Citations (Scopus)

Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3

Gambardella, L., Anderson, K. E., Jakus, Z., Kovács, M., Voigt, S., Hawkins, P. T., Stephens, L., Mócsai, A. & Vermeren, S., Jan 1 2013, In : Journal of Immunology. 190, 1, p. 381-391 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways

Futosi, K., Fodor, S. & Mócsai, A., Dec 1 2013, In : International Immunopharmacology. 17, 4, p. 1185-1197 13 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)
56 Citations (Scopus)

Tyrosine kinase inhibitors for the treatment of rheumatoid arthritis

Gomez-Puerta, J. A. & Mócsai, A., Jun 14 2013, In : Current topics in medicinal chemistry. 13, 6, p. 760-773 14 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2014

Differential regulatory role of pituitary adenylate cyclase-activating polypeptide in the serum-transfer arthritis model

Botz, B., Bölcskei, K., Kereskai, L., Kovács, M., Németh, T., Szigeti, K., Horváth, I., Máthé, D., Kovács, N., Hashimoto, H., Reglödi, D., Szolcsányi, J., Pintér, E., Mõcsai, A. & Helyes, Z., Oct 1 2014, In : Arthritis and Rheumatology. 66, 10, p. 2739-2750 12 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

MASP-1 induces a unique cytokine pattern in endothelial cells: A novel link between complement system and neutrophil granulocytes

Jani, P. K., Kajdácsi, E., Megyeri, M., Dobó, J., Doleschall, Z., Futosi, K., Tímár, C. I., Mócsai, A., Makó, V., Gál, P. & Cervenak, L., Jan 29 2014, In : PloS one. 9, 1, e87104.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage

Schwab, L., Goroncy, L., Palaniyandi, S., Gautam, S., Triantafyllopoulou, A., Mocsai, A., Reichardt, W., Karlsson, F. J., Radhakrishnan, S. V., Hanke, K., Schmitt-Graeff, A., Freudenberg, M., Von Loewenich, F. D., Wolf, P., Leonhardt, F., Baxan, N., Pfeifer, D., Schmah, O., Schönle, A., Martin, S. F. & 9 others, Mertelsmann, R., Duyster, J., Finke, J., Prinz, M., Henneke, P., Häcker, H., Hildebrandt, G. C., Häcker, G. & Zeiser, R., Jun 2014, In : Nature medicine. 20, 6, p. 648-654 7 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Research update for articles published in EJCI in 2012

Dullaart, R. P. F., Al-Daghri, N. M., Ashina, M., Bouzas-Mosquera, A., Brunetti, N. D., Buechler, C., Chen, H. S., Corrales, J. J., D'Archivio, M., Cas, A. D., Pino, G. G., Gómez-Abril, S. A., Gyori, D., Haslacher, H., Herder, C., Kerstens, M. N., Koutsilieris, M., Lombardi, C., Lupattelli, G., Mócsai, A. & 26 others, Msaouel, P., Orfao, A., Ormazabal, P., Pacher, R., Perkmann, T., Peteiro, J., Plischke, M., Reynaert, N. L., Ricci, M. A., Robles, N. R., Rocha, M., Rutten, E. P. A., Sabico, S., Santamaria, F., Santoro, F., Schmid, A., Schmidt, M., Schytz, H. W., Shyu, K. G., Tada, H., Thorand, B., Valerio, G., Vesely, D. L., Wu, T. E., Yamagishi, M. & Yeh, Y. T., Oct 1 2014, In : European Journal of Clinical Investigation. 44, 10, p. 1010-1023 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The phosphoinositide 3-kinase isoform pi3kβ regulates osteoclast-mediated bone resorption in humans and mice

Györi, D., Csete, D., Benkö, S., Kulkarni, S., Mandl, P., Dobõ-Nagy, C., Vanhaesebroeck, B., Stephens, L., Hawkins, P. T. & Mõcsai, A., Aug 2014, In : Arthritis and Rheumatology. 66, 8, p. 2210-2221 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

Kova´cs, M., Ne´meth, T., Jakus, Z., Sitaru, C., Simon, E., Futosi, K., Botz, B., Helyes, Z., Lowell, C. A. & Mo´csai, A., Jan 1 2014, In : Journal of Experimental Medicine. 211, 10, p. 1993-2011 19 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

What is the future of targeted therapy in rheumatology: Biologics or small molecules?

Mócsai, A., Kovács, L. & Gergely, P., Mar 13 2014, In : BMC Medicine. 12, 1, 43.

Research output: Contribution to journalArticle

59 Citations (Scopus)
2015

Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis

Borbély, É., Botz, B., Bölcskei, K., Kenyér, T., Kereskai, L., Kiss, T., Szolcsányi, J., Pintér, E., Csepregi, J. Z., Mócsai, A. & Helyes, Z., Mar 1 2015, In : Brain, Behavior, and Immunity. 45, p. 50-59 10 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Erratum: Targeting vascular endothelial growth factor receptor 2 and protein kinase d1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro (PLoS ONE)

Varga, A., Gyulavári, P., Greff, Z., Futosi, K., Nemeth, T., Simon-Szabó, L., Kerekes, K., Szántai-Kis, C., Brauswetter, D., Kokas, M., Borbely, G., Erdei, A., Mócsai, A., Kéri, G. & Vántus, T., Dec 1 2015, In : PLoS One. 10, 12, e0144792.

Research output: Contribution to journalArticle

Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility

Medina, I., Cougoule, C., Drechsler, M., Bermudez, B., Koenen, R. R., Sluimer, J., Wolfs, I., Döring, Y., Herias, V., Gijbels, M., Bot, I., De Jager, S. C. A., Weber, C., Cleutjens, J., Van Berkel, T. J. C., Sikkink, K. J., Mócsai, A., Maridonneau-Parini, I., Soehnlein, O. & Biessen, E. A. L., Aug 11 2015, In : Circulation. 132, 6, p. 490-501 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity

Weber, F. C., Németh, T., Csepregi, J. Z., Dudeck, A., Roers, A., Ozsvári, B., Oswald, E., Puskás, L. G., Jakob, T., Mócsai, A. & Martin, S. F., Jan 1 2015, In : Journal of Experimental Medicine. 212, 1, p. 15-22 8 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Targeting vascular endothelial growth factor receptor 2 and protein kinase D1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro

Varga, A., Gyulavári, P., Greff, Z., Futosi, K., Németh, T., Simon-Szabó, L., Kerekes, K., Szántai-Kis, C., Brauswetter, D., Kokas, M., Borbély, G., Erdei, A., Mócsai, A., Kéri, G. & Vántus, T., Apr 14 2015, In : PloS one. 10, 4, e0124234.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology

Oliveira, G. P., Silva, J. D., Marques, P. S., Gonçalves-De-Albuquerque, C. F., Santos, H. L., Vascocellos, A. P., Takiya, C. M., Morales, M. M., Pelosi, P., Mócsai, A., De Castro-Faria-Neto, H. C. & Rocco, P. R. M., Jan 1 2015, In : Cellular Physiology and Biochemistry. 36, 4, p. 1644-1658 15 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)