• 6553 Citations
  • 39 h-Index
19972019

Research output per year

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Research Output

  • 6553 Citations
  • 39 h-Index
  • 67 Article
  • 12 Review article
  • 2 Editorial
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Article
2019

Hematopoietic or osteoclast-specific deletion of Syk leads to increased bone mass in experimental mice

Csete, D., Simon, E., Alatshan, A., Aradi, P., Dobó-Nagy, C., Jakus, Z., Benko, S., Gyori, D. S. & Mócsai, A., Jan 1 2019, In : Frontiers in immunology. 10, APR, 937.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Importance of Fc Receptor γ-Chain ITAM Tyrosines in Neutrophil Activation and in vivo Autoimmune Arthritis

Németh, T., Futosi, K., Szabó, M., Aradi, P., Saito, T., Mócsai, A. & Jakus, Z., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access

TRPA1 ion channel determines beneficial and detrimental effects of GYY4137 in murine serum-transfer arthritis

Bátai, I. Z., Sár, C. P., Horváth, Á., Borbély, É., Bölcskei, K., Kemény, Á., Sándor, Z., Nemes, B., Helyes, Z., Perkecz, A., Mócsai, A., Pozsgai, G. & Pintér, E., Jan 1 2019, In : Frontiers in Pharmacology. 10, 964.

Research output: Contribution to journalArticle

Open Access
2018
6 Citations (Scopus)

Lineage-specific analysis of Syk function in autoantibody-induced arthritis

Németh, T., Futosi, K., Szilveszter, K., Vilinovszki, O., Kiss-Pápai, L. & Mócsai, A., Mar 19 2018, In : Frontiers in Immunology. 9, MAR, 555.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Myeloid-specific deletion of Mcl-1 yields severely neutropenic mice that survive and breed in homozygous form

Csepregi, J. Z., Orosz, A., Zajta, E., Kasa, O., Németh, T., Simon, E., Fodor, S., Csonka, K., Baratki, B. L., Kovesdi, D., He, Y. W., Gácser, A. & Mócsai, A., Dec 15 2018, In : Journal of Immunology. 201, 12, p. 3793-3803 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases

Wannick, M., Bezdek, S., Guillen, N., Thieme, M., Meshrkey, F., Mousavi, S., Seeling, M., Nimmerjahn, F., Mócsai, A., Zillikens, D., Sezin, T. & Sadik, C. D., Dec 1 2018, In : Pharmacology Research and Perspectives. 6, 6, e00438.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The Yin and Yang of tyrosine kinase inhibition during experimental polymicrobial sepsis

Gonçalves-de-Albuquerque, C. F., Rohwedder, I., Silva, A. R., Ferreira, A. S., Kurz, A. R. M., Cougoule, C., Klapproth, S., Eggersmann, T., Silva, J. D., de Oliveira, G. P., Capelozzi, V. L., Schlesinger, G. G., Costa, E. R., Elias Estrela Marins, R. D. C., Mócsai, A., Maridonneau-Parini, I., Walzog, B., Rocco, P. R. M., Sperandio, M. & de Castro-Faria-Neto, H. C., Apr 30 2018, In : Frontiers in immunology. 9, APR, 901.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps

Kienhöfer, D., Hahn, J., Stoof, J., Csepregi, J. Z., Reinwald, C., Urbonaviciute, V., Johnsson, C., Maueröder, C., Podolska, M. J., Biermann, M. H., Leppkes, M., Harrer, T., Hultqvist, M., Olofsson, P., Munoz, L. E., Mócsai, A., Herrmann, M., Schett, G., Holmdahl, R. & Hoffmann, M. H., May 18 2017, In : JCI insight. 2, 10

Research output: Contribution to journalArticle

Open Access
38 Citations (Scopus)

Extracellular vesicles regulate the human osteoclastogenesis: divergent roles in discrete inflammatory arthropathies

Marton, N., Kovács, O. T., Baricza, E., Kittel, A., Győri, D., Mócsai, A., Meier, F. M. P., Goodyear, C. S., McInnes, I. B., Búzás, E. & Nagy, G., Oct 1 2017, In : Cellular and Molecular Life Sciences. 74, 19, p. 3599-3611 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The Syk Tyrosine Kinase Is Required for Skin Inflammation in an In Vivo Mouse Model of Epidermolysis Bullosa Acquisita

Németh, T., Virtic, O., Sitaru, C. & Mócsai, A., Oct 2017, In : Journal of Investigative Dermatology. 137, 10, p. 2131-2139 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2016

Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage

Németh, B., Doczi, J., Csete, D., Kacso, G., Ravasz, D., Adams, D., Kiss, G., Nagy, A. M., Horvath, G., Tretter, L., Mócsai, A., Csépányi-Kömi, R., Iordanov, I., Adam-Vizi, V. & Chinopoulos, C., Jan 1 2016, In : FASEB Journal. 30, 1, p. 286-300 15 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Lack of Galanin 3 Receptor Aggravates Murine Autoimmune Arthritis

Botz, B., Kemény, Á., Brunner, S. M., Locker, F., Csepregi, J., Mócsai, A., Pintér, E., McDougall, J. J., Kofler, B. & Helyes, Z., Jun 1 2016, In : Journal of Molecular Neuroscience. 59, 2, p. 260-269 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo

Németh, T., Futosi, K., Sitaru, C., Ruland, J. & Mócsai, A., Apr 1 2016, In : Nature Communications. 7, 11004.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Nicotinic acetylcholine receptors modulate osteoclastogenesis

Mandl, P., Hayer, S., Karonitsch, T., Scholze, P., Gyori, D., Sykoutri, D., Blüml, S., Mócsai, A., Poór, G., Huck, S., Smolen, J. S. & Redlich, K., Mar 12 2016, In : Arthritis Research and Therapy. 18, 1, 63.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Repercussion of megakaryocyte-specific Gata1 Loss on megakaryopoiesis and the hematopoietic precursor compartment

Meinders, M., Hoogenboezem, M., Scheenstra, M. R., De Cuyper, I. M., Papadopoulos, P., Németh, T., Mócsai, A., Van Den Berg, T. K., Kuijpers, T. W. & Gutiérrez, L., May 1 2016, In : PloS one. 11, 5, e0154342.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Urine/plasma neutrophil gelatinase associated lipocalin ratio is a sensitive and specific marker of subclinical acute kidney injury in mice

Kaucsár, T., Godó, M., Révész, C., Kovács, M., Mócsai, A., Kiss, N., Albert, M., Krenács, T., Szénási, G. & Hamar, P., Jan 1 2016, In : PLoS One. 11, 1, 0148043.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2015

Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis

Borbély, É., Botz, B., Bölcskei, K., Kenyér, T., Kereskai, L., Kiss, T., Szolcsányi, J., Pintér, E., Csepregi, J. Z., Mócsai, A. & Helyes, Z., Mar 1 2015, In : Brain, Behavior, and Immunity. 45, p. 50-59 10 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Erratum: Targeting vascular endothelial growth factor receptor 2 and protein kinase d1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro (PLoS ONE)

Varga, A., Gyulavári, P., Greff, Z., Futosi, K., Nemeth, T., Simon-Szabó, L., Kerekes, K., Szántai-Kis, C., Brauswetter, D., Kokas, M., Borbely, G., Erdei, A., Mócsai, A., Kéri, G. & Vántus, T., Dec 1 2015, In : PLoS One. 10, 12, e0144792.

Research output: Contribution to journalArticle

Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility

Medina, I., Cougoule, C., Drechsler, M., Bermudez, B., Koenen, R. R., Sluimer, J., Wolfs, I., Döring, Y., Herias, V., Gijbels, M., Bot, I., De Jager, S. C. A., Weber, C., Cleutjens, J., Van Berkel, T. J. C., Sikkink, K. J., Mócsai, A., Maridonneau-Parini, I., Soehnlein, O. & Biessen, E. A. L., Aug 11 2015, In : Circulation. 132, 6, p. 490-501 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity

Weber, F. C., Németh, T., Csepregi, J. Z., Dudeck, A., Roers, A., Ozsvári, B., Oswald, E., Puskás, L. G., Jakob, T., Mócsai, A. & Martin, S. F., Jan 1 2015, In : Journal of Experimental Medicine. 212, 1, p. 15-22 8 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Targeting vascular endothelial growth factor receptor 2 and protein kinase D1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro

Varga, A., Gyulavári, P., Greff, Z., Futosi, K., Németh, T., Simon-Szabó, L., Kerekes, K., Szántai-Kis, C., Brauswetter, D., Kokas, M., Borbély, G., Erdei, A., Mócsai, A., Kéri, G. & Vántus, T., Apr 14 2015, In : PloS one. 10, 4, e0124234.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology

Oliveira, G. P., Silva, J. D., Marques, P. S., Gonçalves-De-Albuquerque, C. F., Santos, H. L., Vascocellos, A. P., Takiya, C. M., Morales, M. M., Pelosi, P., Mócsai, A., De Castro-Faria-Neto, H. C. & Rocco, P. R. M., Jan 1 2015, In : Cellular Physiology and Biochemistry. 36, 4, p. 1644-1658 15 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2014

Differential regulatory role of pituitary adenylate cyclase-activating polypeptide in the serum-transfer arthritis model

Botz, B., Bölcskei, K., Kereskai, L., Kovács, M., Németh, T., Szigeti, K., Horváth, I., Máthé, D., Kovács, N., Hashimoto, H., Reglödi, D., Szolcsányi, J., Pintér, E., Mõcsai, A. & Helyes, Z., Oct 1 2014, In : Arthritis and Rheumatology. 66, 10, p. 2739-2750 12 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

MASP-1 induces a unique cytokine pattern in endothelial cells: A novel link between complement system and neutrophil granulocytes

Jani, P. K., Kajdácsi, E., Megyeri, M., Dobó, J., Doleschall, Z., Futosi, K., Tímár, C. I., Mócsai, A., Makó, V., Gál, P. & Cervenak, L., Jan 29 2014, In : PloS one. 9, 1, e87104.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage

Schwab, L., Goroncy, L., Palaniyandi, S., Gautam, S., Triantafyllopoulou, A., Mocsai, A., Reichardt, W., Karlsson, F. J., Radhakrishnan, S. V., Hanke, K., Schmitt-Graeff, A., Freudenberg, M., Von Loewenich, F. D., Wolf, P., Leonhardt, F., Baxan, N., Pfeifer, D., Schmah, O., Schönle, A., Martin, S. F. & 9 others, Mertelsmann, R., Duyster, J., Finke, J., Prinz, M., Henneke, P., Häcker, H., Hildebrandt, G. C., Häcker, G. & Zeiser, R., Jun 2014, In : Nature medicine. 20, 6, p. 648-654 7 p.

Research output: Contribution to journalArticle

110 Citations (Scopus)

Research update for articles published in EJCI in 2012

Dullaart, R. P. F., Al-Daghri, N. M., Ashina, M., Bouzas-Mosquera, A., Brunetti, N. D., Buechler, C., Chen, H. S., Corrales, J. J., D'Archivio, M., Cas, A. D., Pino, G. G., Gómez-Abril, S. A., Gyori, D., Haslacher, H., Herder, C., Kerstens, M. N., Koutsilieris, M., Lombardi, C., Lupattelli, G., Mócsai, A. & 26 others, Msaouel, P., Orfao, A., Ormazabal, P., Pacher, R., Perkmann, T., Peteiro, J., Plischke, M., Reynaert, N. L., Ricci, M. A., Robles, N. R., Rocha, M., Rutten, E. P. A., Sabico, S., Santamaria, F., Santoro, F., Schmid, A., Schmidt, M., Schytz, H. W., Shyu, K. G., Tada, H., Thorand, B., Valerio, G., Vesely, D. L., Wu, T. E., Yamagishi, M. & Yeh, Y. T., Oct 1 2014, In : European Journal of Clinical Investigation. 44, 10, p. 1010-1023 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The phosphoinositide 3-kinase isoform pi3kβ regulates osteoclast-mediated bone resorption in humans and mice

Györi, D., Csete, D., Benkö, S., Kulkarni, S., Mandl, P., Dobõ-Nagy, C., Vanhaesebroeck, B., Stephens, L., Hawkins, P. T. & Mõcsai, A., Aug 2014, In : Arthritis and Rheumatology. 66, 8, p. 2210-2221 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

Kova´cs, M., Ne´meth, T., Jakus, Z., Sitaru, C., Simon, E., Futosi, K., Botz, B., Helyes, Z., Lowell, C. A. & Mo´csai, A., Jan 1 2014, In : Journal of Experimental Medicine. 211, 10, p. 1993-2011 19 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

What is the future of targeted therapy in rheumatology: Biologics or small molecules?

Mócsai, A., Kovács, L. & Gergely, P., Mar 13 2014, In : BMC Medicine. 12, 1, 43.

Research output: Contribution to journalArticle

56 Citations (Scopus)
2013

Neutrophil cell surface receptors and their intracellular signal transduction pathways

Futosi, K., Fodor, S. & Mócsai, A., Sep 17 2013, In : International Immunopharmacology. 17, 3, p. 638-650 13 p.

Research output: Contribution to journalArticle

222 Citations (Scopus)

Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3

Gambardella, L., Anderson, K. E., Jakus, Z., Kovács, M., Voigt, S., Hawkins, P. T., Stephens, L., Mócsai, A. & Vermeren, S., Jan 1 2013, In : Journal of Immunology. 190, 1, p. 381-391 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways

Futosi, K., Fodor, S. & Mócsai, A., Dec 1 2013, In : International Immunopharmacology. 17, 4, p. 1185-1197 13 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)
55 Citations (Scopus)

Tyrosine kinase inhibitors for the treatment of rheumatoid arthritis

Gomez-Puerta, J. A. & Mócsai, A., Jun 14 2013, In : Current topics in medicinal chemistry. 13, 6, p. 760-773 14 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2012

Dasatinib inhibits proinflammatory functions of mature human neutrophils

Futosi, K., Németh, T., Pick, R., Vántus, T., Walzog, B. & Mócsai, A., May 24 2012, In : Blood. 119, 21, p. 4981-4991 11 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Optimization of important early ADME(T) parameters of NADPH oxidase-4 inhibitor molecules

Borbély, G., Huszár, M., Varga, A., Futosi, K., Mócsai, A., Orfi, L., Idei, M., Mandl, J., Kéri, G. & Vántus, T., Mar 2012, In : Medicinal Chemistry. 8, 2, p. 174-181 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Phospholipase Cγ2 is required for basal but not oestrogen deficiency-induced bone resorption

Kertész, Z., Gyori, D., Körmendi, S., Fekete, T., Kis-Tóth, K., Jakus, Z., Schett, G., Rajnavölgyi, É., Dobó-Nagy, C. & Mócsai, A., Jan 1 2012, In : European Journal of Clinical Investigation. 42, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The role of neutrophils in autoimmune diseases

Németh, T. & Mócsai, A., Mar 30 2012, In : Immunology letters. 143, 1, p. 9-19 11 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)
2011

Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae

Boyle, K. B., Gyori, D., Sindrilaru, A., Scharffetter-Kochanek, K., Taylor, P. R., Mócsai, A., Stephens, L. R. & Hawkins, P. T., Mar 1 2011, In : Journal of Immunology. 186, 5, p. 2978-2989 12 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

PI3Kβ plays a critical role in neutrophil activation by immune complexes

Kulkarni, S., Sitaru, C., Jakus, Z., Anderson, K. E., Damoulakis, G., Davidson, K., Hirose, M., Juss, J., Oxley, D., Chessa, T. A. M., Ramadani, F., Guillou, H., Segonds-Pichon, A., Fritsch, A., Jarvis, G. E., Okkenhaug, K., Ludwig, R., Zillikens, D., Mocsai, A., Vanhaesebroeck, B. & 2 others, Stephens, L. R. & Hawkins, P. T., Apr 12 2011, In : Science Signaling. 4, 168, ra23.

Research output: Contribution to journalArticle

98 Citations (Scopus)
2010

Genetic deficiency of Syk protects mice from autoantibody-induced arthritis

Jakus, Z., Simon, E., Balázs, B. & Mócsai, A., Jul 1 2010, In : Arthritis and rheumatism. 62, 7, p. 1899-1910 12 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: Generation and analysis of a novel null mutation in mice

Németh, T., Futosi, K., Hably, C., Brouns, M. R., Jakob, S. M., Kovács, M., Kertész, Z., Walzog, B., Settleman, J. & Mócsai, A., Sep 1 2010, In : Journal of Immunology. 185, 5, p. 3064-3075 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2009

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FclRγ-Syk- Card9-dependent innate immune activation

Werninghaus, K., Babiak, A., Groß, O., Hölscher, C., Dietrich, H., Agger, E. M., Mages, J., Mocsai, A., Schoenen, H., Finger, K., Nimmerjahn, F., Brown, G. D., Kirschning, C., Heit, A., Andersen, P., Wagner, H., Ruland, J. & Lang, R., Jan 16 2009, In : Journal of Experimental Medicine. 206, 1, p. 89-97 9 p.

Research output: Contribution to journalArticle

202 Citations (Scopus)

A fundamental role of mAbp1 in neutrophils: Impact on β2 integrin-mediated phagocytosis and adhesion in vivo

Schymeinsky, J., Gerstl, R., Mannigel, I., Niedung, K., Frommhold, D., Panthel, K., Heesemann, J., Sixt, M., Quast, T., Kolanus, W., Mocsai, A., Wienands, J., Sperandio, M. & Walzog, B., Nov 5 2009, In : Blood. 114, 19, p. 4209-4220 12 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

Jakus, Z., Simon, E., Frommhold, D., Sperandio, M. & Mócsai, A., Mar 16 2009, In : Journal of Experimental Medicine. 206, 3, p. 577-593 17 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Gross, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V., Mocsai, A., Tschopp, J. & Ruland, J., May 21 2009, In : Nature. 459, 7245, p. 433-436 4 p.

Research output: Contribution to journalArticle

572 Citations (Scopus)
2008

Critical but overlapping role of FcγRIII and FcγRIV in activation of murine neutrophils by immobilized immune complexes

Jakus, Z., Németh, T., Verbeek, J. S. & Mócsai, A., Jan 1 2008, In : Journal of Immunology. 180, 1, p. 618-629 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2007

Spleen tyrosine kinase Syk is critical for sustained leukocyte adhesion during inflammation in vivo

Frommhold, D., Mannigel, I., Schymeinsky, J., Mocsai, A., Poeschl, J., Walzog, B. & Sperandio, M., Nov 28 2007, In : BMC Immunology. 8, 31.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2006

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

Mócsai, A., Abram, C. L., Jakus, Z., Hu, Y., Lanier, L. L. & Lowell, C. A., Dec 1 2006, In : Nature Immunology. 7, 12, p. 1326-1333 8 p.

Research output: Contribution to journalArticle

246 Citations (Scopus)