• 1838 Citations
  • 22 h-Index
20012019
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Research Output 2001 2019

  • 1838 Citations
  • 22 h-Index
  • 69 Article
  • 2 Review article
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Article
2019

Eicosanoid production by Candida parapsilosis and other pathogenic yeasts

Chakraborty, T., Tóth, R. & Gácser, A., Jan 1 2019, (Accepted/In press) In : Virulence.

Research output: Contribution to journalArticle

Eicosanoids
Candida
Yeasts
Lipids
Biosynthetic Pathways

Functional characterization of secreted aspartyl proteases in Candida parapsilosis

Singh, D. K., Németh, T., Papp, A., Tóth, R., Lukácsi, S., Heidingsfeld, O., Dostal, J., Vágvölgyi, C., Bajtay, Z., Józsi, M. & Gácser, A., Jan 1 2019, In : mSphere. 4, 4, e00484-19.

Research output: Contribution to journalArticle

Open Access
Aspartic Acid Proteases
Complement Factor H
Candida
Complement C4b
Virulence
1 Citation (Scopus)

Multi-omics Signature of Candida auris, an Emerging and Multidrug-Resistant Pathogen

Zamith-Miranda, D., Heyman, H. M., Cleare, L. G., Couvillion, S. P., Clair, G. C., Bredeweg, E. L., Gácser, A., Nimrichter, L., Nakayasu, E. S. & Nosanchuk, J. D., Jul 1 2019, In : mSystems. 4, 4, e00257-19.

Research output: Contribution to journalArticle

Open Access
Candida
Pathogens
Fungi
Candida albicans
drug resistance

Trk1-mediated potassium uptake contributes to cell-surface properties and virulence of Candida glabrata

Llopis-Torregrosa, V., Vaz, C., Monteoliva, L., Ryman, K., Engstrom, Y., Gácser, A., Gil, C., Ljungdahl, P. O. & Sychrová, H., Dec 1 2019, In : Scientific reports. 9, 1, 7529.

Research output: Contribution to journalArticle

Open Access
Candida glabrata
Surface Properties
Virulence
Potassium
Macrophages
2018
2 Citations (Scopus)

CORT0C04210 is required for Candida orthopsilosis adhesion to human buccal cells

Zoppo, M., Lombardi, L., Rizzato, C., Lupetti, A., Bottai, D., Papp, C., Gácser, A. & Tavanti, A., Nov 1 2018, In : Fungal Genetics and Biology. 120, p. 19-29 11 p.

Research output: Contribution to journalArticle

Cheek
Candida
Clustered Regularly Interspaced Short Palindromic Repeats
Virulence
Epithelial Cells
1 Citation (Scopus)

Echinocandin-Induced Microevolution of Candida parapsilosis Influences Virulence and Abiotic Stress Tolerance

Papp, C., Kocsis, K., Tóth, R., Bodai, L., Willis, J. R., Ksiezopolska, E., Lozoya-Pérez, N. E., Vágvölgyi, C., Mora Montes, H., Gabaldón, T., Nosanchuk, J. D. & Gácser, A., Nov 14 2018, In : mSphere. 3, 6

Research output: Contribution to journalArticle

Echinocandins
Candida
Virulence
Candida albicans
Infection
4 Citations (Scopus)

Eicosanoid biosynthesis influences the virulence of candida parapsilosis

Chakraborty, T., Thuer, E., Heijink, M., Tóth, R., Bodai, L., Vágvölgyi, C., Giera, M., Gabaldón, T. & Gácser, A., Jan 1 2018, In : Virulence. 9, 1, p. 1019-1035 17 p.

Research output: Contribution to journalArticle

Eicosanoids
Candida
Virulence
Genes
Prostaglandins
5 Citations (Scopus)

Investigation of Candida parapsilosis virulence regulatory factors during host-pathogen interaction

Tóth, R., Cabral, V., Thuer, E., Bohner, F., Németh, T., Papp, C., Nimrichter, L., Molnár, G., Vágvölgyi, C., Gabaldón, T., Nosanchuk, J. D. & Gácser, A., Dec 1 2018, In : Scientific Reports. 8, 1, 1346.

Research output: Contribution to journalArticle

Host-Pathogen Interactions
Virulence Factors
Candida
Virulence
Infection
1 Citation (Scopus)

Myeloid-specific deletion of Mcl-1 yields severely neutropenic mice that survive and breed in homozygous form

Csepregi, J. Z., Orosz, A., Zajta, E., Kasa, O., Németh, T., Simon, E., Fodor, S., Csonka, K., Baratki, B. L., Kovesdi, D., He, Y. W., Gácser, A. & Mócsai, A., Dec 15 2018, In : Journal of Immunology. 201, 12, p. 3793-3803 11 p.

Research output: Contribution to journalArticle

Neutrophils
Neutropenia
Genetic Models
Epidermolysis Bullosa Acquisita
Specific Pathogen-Free Organisms
2017
1 Citation (Scopus)

Eukaryotic transporters for hydroxyderivatives of benzoic acid

Cillingová, A., Zeman, I., Tóth, R., Neboháčová, M., Dunčková, I., Hölcová, M., Jakúbková, M., Gérecová, G., Pryszcz, L. P., Tomáška, LU., Gabaldón, T., Gácser, A. & Nosek, J., Dec 1 2017, In : Scientific Reports. 7, 1, 8998.

Research output: Contribution to journalArticle

Hydroxybenzoates
Benzoic Acid
Membrane Transport Proteins
Gentisates
Symporters
2 Citations (Scopus)

Investigation of OCH1 in the virulence of Candida parapsilosis using a new neonatal mouse model

Csonka, K., Vadovics, M., Marton, A., Vágvölgyi, C., Zajta, E., Tóth, A., Tóth, R., Vízler, C., Tiszlavicz, L., Mora-Montes, H. M. & Gácser, A., Jun 30 2017, In : Frontiers in Microbiology. 8, JUN, 1197.

Research output: Contribution to journalArticle

Candida
Virulence
Infection
Spleen
Kidney
6 Citations (Scopus)

Six Key Traits of Fungi: Their Evolutionary Origins and Genetic Bases

Nagy, L. G., Tóth, R., Kiss, E., Slot, J., Gácser, A. & Kovács, G., Jul 1 2017, In : Microbiology spectrum. 5, 4

Research output: Contribution to journalArticle

Fungi
fungus
common ancestry
Mycorrhizae
Secondary Metabolism
9 Citations (Scopus)

Specific pathways mediating inflammasome activation by Candida parapsilosis

Tóth, A., Zajta, E., Csonka, K., Vágvölgyi, C., Netea, M. G. & Gácser, A., Feb 22 2017, In : Scientific Reports. 7, 43129.

Research output: Contribution to journalArticle

Inflammasomes
Interleukin-1
Candida
Candida albicans
Caspase 1
2016
2 Citations (Scopus)

Adhesins in Candida parapsilosis: Understudied players in virulence

Gácser, A., Feb 17 2016, In : Virulence. 7, 2, p. 65-67 3 p.

Research output: Contribution to journalArticle

Bacterial Adhesins
Candidiasis
Candida
Virulence
3 Citations (Scopus)

Analysis of oral yeast microflora in patients with oral squamous cell carcinoma

Berkovits, C., Tóth, A., Szenzenstein, J., Deák, T., Urbán, E., Gácser, A. & Nagy, K., Dec 1 2016, In : SpringerPlus. 5, 1, 1257.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Yeasts
Candida
Mouth
Mouth Neoplasms
20 Citations (Scopus)

Members of the Candida parapsilosis complex and Candida albicans are differentially recognized by human peripheral blood mononuclear cells

Estrada-Mata, E., Navarro-Arias, M. J., Pérez-García, L. A., Mellado-Mojica, E., López, M. G., Csonka, K., Gácser, A. & Mora-Montes, H. M., 2016, In : Frontiers in Microbiology. 6, JAN, 1527.

Research output: Contribution to journalArticle

Candida albicans
Candida
Blood Cells
Mannans
Glucans
22 Citations (Scopus)

Role of protein glycosylation in Candida parapsilosis cell wall integrity and host interaction

Pérez-García, L. A., Csonka, K., Flores-Carreón, A., Estrada-Mata, E., Mellado-Mojica, E., Németh, T., López-Ramírez, L. A., Toth, R., López, M. G., Vízler, C., Marton, A., Tóth, A., Nosanchuk, J. D., Gácser, A. & Mora-Montes, H. M., Mar 8 2016, In : Frontiers in Microbiology. 7, MAR, 306.

Research output: Contribution to journalArticle

Mannans
Glycosylation
Candida
Cell Wall
Candida albicans
2015
15 Citations (Scopus)

Candida parapsilosis produces prostaglandins from exogenous arachidonic acid and OLE2 is not required for their synthesis

Grózer, Z., Tóth, A., Tóth, R., Kecskeméti, A., Vágvölgyi, C., Nosanchuk, J. D., Szekeres, A. & Gácser, A., Feb 5 2015, In : Virulence. 6, 1, p. 85-92 8 p.

Research output: Contribution to journalArticle

Candida
Arachidonic Acid
Prostaglandins
Dinoprostone
Fatty Acids
4 Citations (Scopus)

Different Candida parapsilosis clinical isolates and lipase deficient strain trigger an altered cellular immune response

Tóth, R., Alonso, M. F., Bain, J. M., Vágvölgyi, C., Erwig, L. P. & Gácser, A., 2015, In : Frontiers in Microbiology. 6, OCT, 1102.

Research output: Contribution to journalArticle

Lipase
Candida
Cellular Immunity
Mycoses
Virulence
3 Citations (Scopus)
HMGB Proteins
Aspergillus nidulans
Mitochondrial Proteins
Oxidation-Reduction
Oxidative Stress
30 Citations (Scopus)

The Genomic Aftermath of Hybridization in the Opportunistic Pathogen Candida metapsilosis

Pryszcz, L. P., Németh, T., Saus, E., Ksiezopolska, E., Hegedűsová, E., Nosek, J., Wolfe, K. H., Gácser, A. & Gabaldón, T., 2015, In : PLoS Genetics. 11, 10, e1005626.

Research output: Contribution to journalArticle

Nucleic Acid Hybridization
Candida
nucleic acid hybridization
genomics
pathogen
2014
7 Citations (Scopus)

A dually located multi-HMG-box protein of Aspergillus nidulans has a crucial role in conidial and ascospore germination

Karácsony, Z., Gácser, A., Vágvölgyi, C., Scazzocchio, C. & Hamari, Z., Oct 1 2014, In : Molecular Microbiology. 94, 2, p. 383-402 20 p.

Research output: Contribution to journalArticle

HMGB Proteins
Aspergillus nidulans
Germination
Sterigmatocystin
Podospora
43 Citations (Scopus)

Comparative Phenotypic Analysis of the Major Fungal Pathogens Candida parapsilosis and Candida albicans

Holland, L. M., Schröder, M. S., Turner, S. A., Taff, H., Andes, D., Grózer, Z., Gácser, A., Ames, L., Haynes, K., Higgins, D. G. & Butler, G., Sep 1 2014, In : PLoS Pathogens. 10, 9

Research output: Contribution to journalArticle

Candida albicans
Candida
Biofilms
Transcription Factors
Protein Kinases
7 Citations (Scopus)

Genetic determinants of virulence - Candida parapsilosis

Singaravelu, K., Gácser, A. & Nosanchuk, J. D., Jan 2014, In : Revista Iberoamericana de Micologia. 31, 1, p. 16-21 6 p.

Research output: Contribution to journalArticle

Candida
Virulence
Gene Deletion
Candida albicans
Genes
40 Citations (Scopus)

Genome comparison of candida orthopsilosis clinical strains reveals the existence of hybrids between two distinct subspecies

Pryszcz, L. P., Németh, T., Gácser, A. & Gabaldón, T., 2014, In : Genome Biology and Evolution. 6, 5, p. 1069-1078 10 p.

Research output: Contribution to journalArticle

Candida
subspecies
Gene Dosage
genome
Genome
11 Citations (Scopus)

Induction of human defensins by intestinal Caco-2 cells after interactions with opportunistic Candida species

Gácser, A., Tiszlavicz, Z., Németh, T., Seprényi, G. & Mándi, Y., Jan 2014, In : Microbes and Infection. 16, 1, p. 80-85 6 p.

Research output: Contribution to journalArticle

Caco-2 Cells
Candida
Cell Communication
alpha-Defensins
Candida albicans
15 Citations (Scopus)

Kinetic studies of Candida parapsilosis phagocytosis by macrophages and detection of intracellular survival mechanisms

Tóth, R., Tóth, A., Papp, C., Jankovics, F., Vágvölgyi, C., Alonso, M. F., Bain, J. M., Erwig, L. P. & Gácser, A., 2014, In : Frontiers in Microbiology. 5, NOV, 633.

Research output: Contribution to journalArticle

Candida
Phagocytosis
Macrophages
Survival
Phagocytes
51 Citations (Scopus)

Latent homology and convergent regulatory evolution underlies the repeated emergence of yeasts

Nagy, L. G., Ohm, R. A., Kovács, G., Floudas, D., Riley, R., Gácser, A., Sipiczki, M., Davis, J. M., Doty, S. L., De Hoog, G. S., Lang, B. F., Spatafora, J. W., Martin, F. M., Grigoriev, I. V. & Hibbett, D. S., Jul 18 2014, In : Nature Communications. 5, 4471.

Research output: Contribution to journalArticle

yeast
homology
Yeast
Yeasts
phenotype
18 Citations (Scopus)

Secreted Candida parapsilosis lipase modulates the immune response of primary human macrophages

Tóth, A., Németh, T., Csonka, K., Horváth, P., Vágvölgyi, C., Vízler, C., Nosanchuk, J. D. & Gácser, A., 2014, In : Virulence. 5, 4, p. 555-562 8 p.

Research output: Contribution to journalArticle

Lipase
Candida
Lip
Macrophages
Interleukin-1
17 Citations (Scopus)

The role of pancreatic ductal secretion in protection against acute pancreatitis in mice

Pallagi, P., Balla, Z., Singh, A. K., Dósa, S., Iványi, B., Kukor, Z., Tóth, A., Riederer, B., Liu, Y., Engelhardt, R., Jármay, K., Szabó, A., Janovszky, Á., Perides, G., Venglovecz, V., Maléth, J., Wittmann, T., Takács, T., Gray, M. A., Gácser, A. & 3 others, Hegyi, P., Seidler, U. & Rakonczay, Z., Mar 2014, In : Critical Care Medicine. 42, 3

Research output: Contribution to journalArticle

Pancreatitis
Acinar Cells
Pancreas
Cystic Fibrosis Transmembrane Conductance Regulator
Acute Necrotizing Pancreatitis
11 Citations (Scopus)

Transcriptome profile of the murine macrophage cell response to Candida parapsilosis

Németh, T., Tóth, A., Hamari, Z., Falus, A., Éder, K., Vágvölgyi, C., Guimaraes, A. J., Nosanchuk, J. D. & Gácser, A., 2014, In : Fungal Genetics and Biology. 65, p. 48-56 9 p.

Research output: Contribution to journalArticle

Transcriptome
Candida
Macrophages
Up-Regulation
Infection
2013
24 Citations (Scopus)

Candida albicans and Candida parapsilosis induce different T-cell responses in human peripheral blood mononuclear cells

Tóth, A., Csonka, K., Jacobs, C., Vágvölgyi, C., Nosanchuk, J. D., Netea, M. G. & Gácser, A., Aug 15 2013, In : Journal of Infectious Diseases. 208, 4, p. 690-698 9 p.

Research output: Contribution to journalArticle

Candida albicans
Candida
Blood Cells
T-Lymphocytes
Cytokines
76 Citations (Scopus)

Candida poropsilosis Is a significant neonatal pathogen: A systematic review and meta-analysis

Pammi, M., Holland, L., Butler, G., Gácser, A. & Bliss, J. M., May 2013, In : Pediatric Infectious Disease Journal. 32, 5

Research output: Contribution to journalArticle

Candida
Meta-Analysis
Neonatal Sepsis
42 Citations (Scopus)

Characterization of Virulence Properties in the C. parapsilosis Sensu Lato Species

Németh, T., Tóth, A., Szenzenstein, J., Horváth, P., Nosanchuk, J. D., Grózer, Z., Tóth, R., Papp, C., Hamari, Z., Vágvölgyi, C. & Gácser, A., Jul 9 2013, In : PLoS One. 8, 7, e68704.

Research output: Contribution to journalArticle

Macrophages
Virulence
macrophages
Lipase
virulence
2 Citations (Scopus)

Differential Sensitivity of the Species of Candida parapsilosis Sensu Lato Complex Against Statins

Szenzenstein, J., Gácser, A., Grózer, Z., Farkas, Z., Nagy, K., Vágvölgyi, C., Márki-Zay, J. & Pfeiffer, I., 2013, In : Mycopathologia. 176, 3-4, p. 211-217 7 p.

Research output: Contribution to journalArticle

Candida parapsilosis
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Candida
fluvastatin
Virulence

Investigation of the role of Lip5-a member of the secreted lipase gene family-in the virulence of Candida albicans

Hamari, Z., Tóth, A., Pintér, L., Németh, T., Horváth, P., Ambrus, V., Vágvölgyi, C. & Gácser, A., 2013, In : Acta Biologica Szegediensis. 57, 1, p. 25-30 6 p.

Research output: Contribution to journalArticle

Candida
Lipase
Candida albicans
Virulence
virulence
25 Citations (Scopus)

The APSES transcription factor Efg1 is a global regulator that controls morphogenesis and biofilm formation in Candida parapsilosis

Connolly, L. A., Riccombeni, A., Grózer, Z., Holland, L. M., Lynch, D. B., Andes, D. R., Gácser, A. & Butler, G., Oct 2013, In : Molecular Microbiology. 90, 1, p. 36-53 18 p.

Research output: Contribution to journalArticle

Biofilms
Morphogenesis
Candida
Transcription Factors
caspofungin
18 Citations (Scopus)

Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis

Pryszcz, L. P., Németh, T., Gácser, A. & Gabaldón, T., 2013, In : Genome Biology and Evolution. 5, 12, p. 2382-2392 11 p.

Research output: Contribution to journalArticle

Candida parapsilosis
Candida
yeast
genomics
Yeasts
2012
13 Citations (Scopus)

Mitochondrial genome variability within the Candida parapsilosis species complex

Valach, M., Pryszcz, L. P., Tomaska, L., Gácser, A., Gabaldón, T. & Nosek, J., Sep 2012, In : Mitochondrion. 12, 5, p. 514-519 6 p.

Research output: Contribution to journalArticle

Mitochondrial Genome
Mitochondrial DNA
Candida
Nucleotides
Yeasts
31 Citations (Scopus)

The identification of gene duplication and the role of secreted aspartyl proteinase 1 in Candida parapsilosis virulence

Horváth, P., Nosanchuk, J. D., Hamari, Z., Vágvölgyi, C. & Gácser, A., Mar 15 2012, In : Journal of Infectious Diseases. 205, 6, p. 923-933 11 p.

Research output: Contribution to journalArticle

Gene Duplication
Candida
Virulence
Blood Cells
Yeasts
11 Citations (Scopus)

The secreted lipase FGL1 is sufficient to restore the initial infection step to the apathogenic Fusarium graminearum MAP kinase disruption mutant Δgpmk1

Salomon, S., Gácser, A., Frerichmann, S., Kröger, C., Schäfer, W. & Voigt, C. A., Sep 2012, In : European Journal of Plant Pathology. 134, 1, p. 23-37 15 p.

Research output: Contribution to journalArticle

Fusarium graminearum
mitogen-activated protein kinase
mutants
infection
pathogenicity
2011
19 Citations (Scopus)

A Rat Model of Neonatal Candidiasis Demonstrates the Importance of Lipases as Virulence Factors for Candida albicans and Candida parapsilosis

Trofa, D., Soghier, L., Long, C., Nosanchuk, J. D., Gácser, A. & Goldman, D. L., Sep 2011, In : Mycopathologia. 172, 3, p. 169-178 10 p.

Research output: Contribution to journalArticle

Candida parapsilosis
candidiasis
Candidiasis
Virulence Factors
Lipase
19 Citations (Scopus)

Candida parapsilosis fat storage-inducing transmembrane (FIT) protein 2 regulates lipid droplet formation and impacts virulence

Nguyen, L. N., Hamari, Z., Kadereit, B., Trofa, D., Agovino, M., Martinez, L. R., Gácser, A., Silver, D. L. & Nosanchuk, J. D., Jul 2011, In : Microbes and Infection. 13, 7, p. 663-672 10 p.

Research output: Contribution to journalArticle

Candida
Virulence
Fats
Proteins
Fungi
19 Citations (Scopus)
Lipase
Candida
Dendritic Cells
Monocytes
Yeasts
7 Citations (Scopus)

Secreted lipases supply fatty acids for yeast growth in the absence of de novo fatty acid synthesis

Nguyen, L. N., Gacser, A. & Nosanchuk, J. D., Nov 2011, In : Virulence. 2, 6, p. 538-541 4 p.

Research output: Contribution to journalArticle

Lipase
Fatty Acids
Yeasts
Growth
Lipids
19 Citations (Scopus)

The stearoyl-coenzyme a desaturase 1 is essential for virulence and membrane stress in candida parapsilosis through unsaturated fatty acid production

NamNguyen, L., Gácser, A. & Nosanchuk, J. D., Jan 2011, In : Infection and Immunity. 79, 1, p. 136-145 10 p.

Research output: Contribution to journalArticle

Coenzymes
Unsaturated Fatty Acids
Candida
Virulence
Membranes
2009
15 Citations (Scopus)

Acetylsalicylic acid (aspirin) reduces damage to reconstituted human tissues infected with Candida species by inhibiting extracellular fungal lipases

Trofa, D., Agovino, M., Stehr, F., Schäfer, W., Rykunov, D., Fiser, A., Hamari, Z., Nosanchuk, J. D. & Gácser, A., Dec 2009, In : Microbes and Infection. 11, 14-15, p. 1131-1139 9 p.

Research output: Contribution to journalArticle

Lipase
Candida
Aspirin
Candida albicans
Growth
34 Citations (Scopus)

Biology and genetics of the pathogenic yeast Candida parapsilosis

Nosek, J., Holesova, Z., Kosa, P., Gácser, A. & Tomaska, L., 2009, In : Current Genetics. 55, 5, p. 497-509 13 p.

Research output: Contribution to journalArticle

Candida
Yeasts
Genome
Biological Phenomena
Schizosaccharomyces
45 Citations (Scopus)

Methamphetamine enhances histoplasmosis by immunosuppression of the host

Martinez, L. R., Mihu, M. R., Gácser, A., Santambrogio, L. & Nosanchuk, J. D., Jul 1 2009, In : Journal of Infectious Diseases. 200, 1, p. 131-141 11 p.

Research output: Contribution to journalArticle

Histoplasmosis
Methamphetamine
Immunosuppression
Histoplasma
Macrophages
2008
28 Citations (Scopus)

A monoclonal antibody to Histoplasma capsulatum alters the intracellular fate of the fungus in murine macrophages

Shi, L., Albuquerque, P. C., Lazar-Molnar, E., Wang, X., Santambrogio, L., Gácser, A. & Nosanchuk, J. D., Jul 2008, In : Eukaryotic Cell. 7, 7, p. 1109-1117 9 p.

Research output: Contribution to journalArticle

Histoplasma capsulatum
Histoplasma
monoclonal antibodies
macrophages
Fungi