• 7922 Citations
  • 34 h-Index
1993 …2019

Research output per year

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Research Output

2019

Assessment of temporal functional changes and miRNA profiling of human iPSC-derived cardiomyocytes

Kumar, N., Dougherty, J. A., Manring, H. R., Elmadbouh, I., Mergaye, M., Czirok, A., Greta Isai, D., Belevych, A. E., Yu, L., Janssen, P. M. L., Fadda, P., Gyorke, S., Ackermann, M. A., Angelos, M. G. & Khan, M., Dec 1 2019, In : Scientific reports. 9, 1, 13188.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Engineering a biomimetic environment to pre-condition stem cells for efficacious cardiovascular repair

Chakravarti, A. R., Pacelli, S., Alam, P., Bagchi, S., Modaresi, S., Czirók, A., Ahmed, R. P. H. & Paul, A., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Enhanced endothelial motility and multicellular sprouting is mediated by the scaffold protein TKS4

Mehes, E., Barath, M., Gulyas, M., Bugyik, E., Geiszt, M., Szoor, A., Lanyi, A. & Czirok, A., Dec 1 2019, In : Scientific reports. 9, 1, 14363.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Epigenetic Priming of Human Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Accelerates Cardiomyocyte Maturation

Biermann, M., Cai, W., Lang, D., Hermsen, J., Profio, L., Zhou, Y., Czirok, A., Isai, D. G., Napiwocki, B. N., Rodriguez, A. M., Brown, M. E., Woon, M. T., Shao, A., Han, T., Park, D., Hacker, T. A., Crone, W. C., Burlingham, W. J., Glukhov, A. V., Ge, Y. & 1 others, Kamp, T. J., Jul 2019, In : Stem Cells. 37, 7, p. 910-923 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Matrigel patterning reflects multicellular contractility

Méhes, E., Biri-Kovács, B., Isai, D. G., Gulyás, M., Nyitray, L. & Czirók, A., 2019, In : PLoS computational biology. 15, 10, e1007431.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Polarization wave at the onset of collective cell migration

Oelz, D., Khataee, H., Czirok, A. & Neufeld, Z., Sep 5 2019, In : Physical Review E. 100, 3, 032403.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

Manipulation-free cultures of human iPSC-derived cardiomyocytes offer a novel screening method for cardiotoxicity

Rajasingh, S., Isai, D. G., Samanta, S., Zhou, Z. G., Dawn, B., Kinsey, W. H., Czirok, A. & Rajasingh, J., Oct 1 2018, In : Acta Pharmacologica Sinica. 39, 10, p. 1590-1603 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Nintedanib is active in malignant pleural mesothelioma cell models and inhibits angiogenesis and tumor growth in vivo

Laszlo, V., Valko, Z., Kovacs, I., Ozsvar, J., Hoda, M. A., Klikovits, T., Lakatos, D., Czirók, A., Garay, T., Stiglbauer, A., Helbich, T. H., Groger, M., Tóvári, J., Klepetko, W., Pirker, C., Grusch, M., Berger, W., Hilberg, F., Hegedus, B. & Döme, B., Aug 1 2018, In : Clinical Cancer Research. 24, 15, p. 3729-3740 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Pre-Conditioning Stem Cells in a Biomimetic Environment for Enhanced Cardiac Tissue Repair: In Vitro and In Vivo Analysis

Chakravarti, A. R., Pacelli, S., Alam, P., Bagchi, S., Modaresi, S., Czirok, A., Ahmed, R. P. H. & Paul, A., Oct 1 2018, In : Cellular and Molecular Bioengineering. 11, 5, p. 321-336 16 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Software tools for cell culture-related 3D printed structures

Gulyas, M., Csiszer, M., Mehes, E. & Czirok, A., Sep 2018, In : PloS one. 13, 9, e0203203.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Soluble VEGFR1 signaling guides vascular patterns into dense branching morphologies

Lakatos, D., Somfai, E., Méhes, E. & Czirók, A., Nov 7 2018, In : Journal of Theoretical Biology. 456, p. 261-278 18 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions

Priya, R., Gomez, G. A., Budnar, S., Acharya, B. R., Czirok, A., Yap, A. S. & Neufeld, Z., Mar 2017, In : PLoS computational biology. 13, 3, e1005411.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Cell Dispersal Influences Tumor Heterogeneity and Introduces a Bias in NGS Data Interpretation

Pongor, L., Harami-Papp, H., Méhes, E., Czirók, A. & Gyorffy, B., Dec 1 2017, In : Scientific reports. 7, 1, 7358.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Optical-flow based non-invasive analysis of cardiomyocyte contractility

Czirok, A., Isai, D. G., Kosa, E., Rajasingh, S., Kinsey, W., Neufeld, Z. & Rajasingh, J., Dec 1 2017, In : Scientific reports. 7, 1, 10404.

Research output: Contribution to journalArticle

11 Citations (Scopus)

The role of Allee effect in modelling post resection recurrence of glioblastoma

Neufeld, Z., von Witt, W., Lakatos, D., Wang, J., Hegedus, B. & Czirok, A., Nov 2017, In : PLoS computational biology. 13, 11, e1005818.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2016

Extracellular matrix motion and early morphogenesis

Loganathan, R., Rongish, B. J., Smith, C. M., Filla, M. B., Czirok, A., Bénazéraf, B. & Little, C. D., Jun 15 2016, In : Development (Cambridge). 143, 12, p. 2056-2065 10 p.

Research output: Contribution to journalReview article

19 Citations (Scopus)

SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination

Wilson, N. R., Olm-Shipman, A. J., Acevedo, D. S., Palaniyandi, K., Hall, E. G., Kosa, E., Stumpff, K. M., Smith, G. J., Pitstick, L., Liao, E. C., Bjork, B. C., Czirok, A. & Saadi, I., Jan 20 2016, In : Scientific reports. 6, 17735.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2015

Active cell and ECM movements during development

Aleksandrova, A., Rongish, B. J., Little, C. D. & Czirók, A., 2015, In : Methods in Molecular Biology. 1189, p. 123-132 10 p.

Research output: Contribution to journalArticle

Anomalous segregation dynamics of self-propelled particles

Mones, E., Czirók, A. & Vicsek, T., Jun 10 2015, In : New Journal of Physics. 17, 6, 063013.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Cell resolved, multiparticle model of plastic tissue deformations and morphogenesis

Czirok, A. & Isai, D. G., Feb 1 2015, In : Physical Biology. 12, 1, 016005.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Generation of functional cardiomyocytes from efficiently generated human iPSCs and a novel method of measuring contractility

Rajasingh, S., Thangavel, J., Czirok, A., Samanta, S., Roby, K. F., Dawn, B. & Rajasingh, J., Aug 3 2015, In : PloS one. 10, 8, e0134093.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The endoderm and myocardium join forces to drive early heart tube assembly

Aleksandrova, A., Czirok, A., Kosa, E., Galkin, O., Cheuvront, T. J. & Rongish, B. J., Aug 1 2015, In : Developmental Biology. 404, 1, p. 40-54 15 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2014

Autocrine FGF feedback can establish distinct states of Nanog expression in pluripotent stem cells: A computational analysis

Lakatos, D., Travis, E. D., Pierson, K. E., Vivian, J. L. & Czirok, A., Sep 27 2014, In : BMC Systems Biology. 8, 1, 112.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2013

Cell migration or cytokinesis and proliferation? - Revisiting the "go or grow" hypothesis in cancer cells in vitro

Garay, T., Juhász, É., Molnár, E., Eisenbauer, M., Czirók, A., Dekan, B., László, V., Hoda, M. A., Döme, B., Tímár, J., Klepetko, W., Berger, W. & Hegedus, B., Dec 10 2013, In : Experimental Cell Research. 319, 20, p. 3094-3103 10 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Collective cell streams in epithelial monolayers depend on cell adhesion

Czirók, A., Varga, K., Méhes, E. & Szabó, A., Jul 2013, In : New Journal of Physics. 15, 075006.

Research output: Contribution to journalArticle

24 Citations (Scopus)
15 Citations (Scopus)
2012

Convective tissue movements play a major role in avian endocardial morphogenesis

Aleksandrova, A., Czirók, A., Szabó, A., Filla, M. B., Hossain, M. J., Whelan, P. F., Lansford, R. & Rongish, B. J., Mar 15 2012, In : Developmental Biology. 363, 2, p. 348-361 14 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Invasion from a cell aggregate - The roles of active cell motion and mechanical equilibrium

Czirók, A., Szabó, A., Varga, K., Garay, T., Hegeds, B., Szabó, A., Varga, K., Garay, T. & Hegeds, B., Feb 2012, In : Physical Biology. 9, 1, 016010.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Pattern formation during vasculogenesis

Czirok, A. & Little, C. D., Jun 2012, In : Birth Defects Research Part C - Embryo Today: Reviews. 96, 2, p. 153-162 10 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)
2011

An active particle-based tracking framework for 2D and 3D time-lapse microscopy images

Hossain, M. J., Whelan, P. F., Czirok, A. & Ghita, O., 2011, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. p. 6613-6618 6 p. 6091631. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Extracellular matrix fluctuations during early embryogenesis

Szabó, A., Rupp, P. A., Rongish, B. J., Little, C. D. & Czirók, A., Aug 2011, In : Physical Biology. 8, 4, 045006.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Inhibition of myosin II triggers morphological transition and increased nuclear motility

Szabó, B., Ünnep, R., Markó, K., Környei, Z., Méhes, E. A. & Czirók, A., Jun 1 2011, In : Cytoskeleton. 68, 6, p. 325-339 15 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior

Sánchez, N. S., Hill, C. R., Love, J. D., Soslow, J. H., Craig, E., Austin, A. F., Brown, C. B., Czirok, A., Camenisch, T. D. & Barnett, J. V., Oct 15 2011, In : Developmental Biology. 358, 2, p. 331-343 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Vascular Network Formation in Expanding versus Static Tissues: Embryos and Tumors

Czirok, A., Rongish, B. J. & Little, C. D., Dec 2011, In : Genes and Cancer. 2, 12, p. 1072-1080 9 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)
2010

Collective cell motion in endothelial monolayers

Szabó, A., Ünnep, R., Méhes, E., Twal, W. O., Argraves, W. S., Cao, Y. & Czirók, A., Dec 2010, In : Physical Biology. 7, 4, 046007.

Research output: Contribution to journalArticle

110 Citations (Scopus)

Dynamic analysis of vascular morphogenesis using transgenic quail embryos

Sato, Y., Poynter, G., Huss, D., Filla, M. B., Czirok, A., Rongish, B. J., Little, C. D., Fraser, S. E. & Lansford, R., 2010, In : PloS one. 5, 9, p. 1-12 12 p., e12674.

Research output: Contribution to journalArticle

93 Citations (Scopus)

The role of cell-cell adhesion in the formation of multicellular sprouts

Szabó, A. & Czirók, A., Jan 2010, In : Mathematical Modelling of Natural Phenomena. 5, 1, p. 106-122 17 p.

Research output: Contribution to journalReview article

26 Citations (Scopus)
2008

Matrix metalloproteinase 2-integrin αvβ3 binding is required for mesenchymal cell invasive activity but not epithelial locomotion: A computational time-lapse study

Rupp, P. A., Visconti, R. P., Czirók, A., Cheresh, D. A. & Little, C. D., Dec 2008, In : Molecular Biology of the Cell. 19, 12, p. 5529-5540 12 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Multicellular Sprouting during Vasculogenesis

Czirok, A., Zamir, E. A., Szabo, A. & Little, C. D., Jan 1 2008, Multiscale Modeling of Developmental Systems. Schnell, S., Maini, P., Newman, S. & Newman, T. (eds.). p. 269-289 21 p. (Current Topics in Developmental Biology; vol. 81).

Research output: Chapter in Book/Report/Conference proceedingChapter

31 Citations (Scopus)

Multicellular sprouting in vitro

Szabo, A., Mehes, E., Kosa, E. & Czirok, A., Sep 15 2008, In : Biophysical journal. 95, 6, p. 2702-2710 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

NMDA receptor NR2B subunit over-expression increases cerebellar granule cell migratory activity

Tárnok, K., Czöndör, K., Jelitai, M., Czirók, A. & Schlett, K., Feb 1 2008, In : Journal of neurochemistry. 104, 3, p. 818-829 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Vascular sprout formation entails tissue deformations and VE-cadherin-dependent cell-autonomous motility

Perryn, E. D., Czirók, A. & Little, C. D., Jan 15 2008, In : Developmental Biology. 313, 2, p. 545-555 11 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
2007

Network formation of tissue cells via preferential attraction to elongated structures

Szabo, A., Perryn, E. D. & Czirok, A., Jan 26 2007, In : Physical review letters. 98, 3, 038102.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Subventricular zone neuronal progenitors undergo multiple divisions and retract their processes prior to each cytokinesis

Coskun, V., Falls, D. L., Lane, R., Czirok, A. & Luskin, M. B., Aug 1 2007, In : European Journal of Neuroscience. 26, 3, p. 593-604 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2006

Elastic fiber formation: A dynamic view of extracellular matrix assembly using timer reporters

Kozel, B. A., Rongish, B. J., Czirok, A., Zach, J., Little, C. D., Davis, E. C., Knutsen, R. H., Wagenseil, J. E., Levy, M. A. & Mecham, R. P., Apr 1 2006, In : Journal of Cellular Physiology. 207, 1, p. 87-96 10 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Elastic fiber macro-assembly is a hierarchical, cell motion-mediated process

Czirok, A., Zach, J., Kozel, B. A., Mecham, R. P., Davis, E. C. & Rongish, B. J., Apr 1 2006, In : Journal of Cellular Physiology. 207, 1, p. 97-106 10 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Extracellular Matrix Macroassembly Dynamics in Early Vertebrate Embryos

Czirok, A., Zamir, E. A., Filla, M. B., Little, C. D. & Rongish, B. J., Jun 19 2006, In : Current Topics in Developmental Biology. 73, p. 237-258 22 p.

Research output: Contribution to journalReview article

38 Citations (Scopus)

Mesodermal cell displacements during avian gastrulation are due to both individual cell-autonomous and convective tissue movements

Zamir, E. A., Czirók, A., Cui, C., Little, C. D. & Rongish, B. J., Dec 26 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 52, p. 19806-19811 6 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

New insights into extracellular matrix assembly and reorganization from dynamic imaging of extracellular matrix proteins in living osteoblasts

Sivakumar, P., Czirok, A., Rongish, B. J., Divakara, V. P., Wang, Y. P. & Dallas, S. L., Apr 1 2006, In : Journal of cell science. 119, 7, p. 1350-1360 11 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
2005

A digital image based method for computational tissue fate mapping during early avian morphogenesis

Zamir, E. A., Czirók, A., Rongish, B. J. & Little, C. D., Dec 1 2005, Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC. p. 7-8 2 p. (Proceedings of the 2005 Summer Bioengineering Conference; vol. 2005).

Research output: Chapter in Book/Report/Conference proceedingConference contribution