• 2448 Citations
  • 25 h-Index
1975 …2018

Research output per year

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Research Output

  • 2448 Citations
  • 25 h-Index
  • 173 Article
  • 2 Conference contribution
  • 2 Comment/debate
  • 1 Editorial
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Article
2018

The effect of increased NaCl intake on rat brain endogenous μ-opioid receptor signalling

Dadam, F., Zádor, F., Caeiro, X., Szűcs, E., Erdei, A., Samavati, R., Gáspár, R., Borsodi, A. & Vivas, L., Apr 1 2018, In : Journal of Neuroendocrinology. 30, 4, e12585.

Research output: Contribution to journalArticle

2017
3 Citations (Scopus)
2016

A novel non-Opioid binding site for endomorphin-1

Lengyel, I., Toth, F., Biyashev, D., Szatmari, I., Monory, K., Tömböly, C., Toth, G., Benyhe, S. & Borsodi, A., Aug 1 2016, In : Journal of Physiology and Pharmacology. 67, 4, p. 605-616 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The effects of estrogen on the α2-adrenergic receptor subtypes in rat uterine function in late pregnancy in vitro

Hajagos-Tóth, J., Bóta, J., Ducza, E., Csányi, A., Tiszai, Z., Borsodi, A., Samavati, R., Benyhe, S. & Gáspár, R., 2016, In : Croatian Medical Journal. 57, 2, p. 100-109 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The effects of progesterone on the alpha2-adrenergic receptor subtypes in late-pregnant uterine contractions in vitro

Hajagos-Tóth, J., Bóta, J., Ducza, E., Samavati, R., Borsodi, A., Benyhe, S. & Gáspár, R., Jun 14 2016, In : Reproductive Biology and Endocrinology. 14, 1, 33.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav2.2 Blocker Multitarget Ligands

Mollica, A., Costante, R., Novellino, E., Stefanucci, A., Pieretti, S., Zador, F., Samavati, R., Borsodi, A., Benyhe, S., Vetter, I. & Lewis, R. J., Jan 1 2015, In : Chemical Biology and Drug Design. 86, 2, p. 156-162 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Further characterization of hemopressin peptide fragments in the opioid and cannabinoid systems

Szlavicz, E., Perera, P. S., Tomboly, C., Helyes, Z., Zador, F., Benyhe, S., Borsodi, A. & Bojnik, E., Dec 1 2015, In : Anesthesia and analgesia. 121, 6, p. 1488-1494 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The effects of female sexual hormones on the expression and function of α1A- and α1D-adrenoceptor subtypes in the late-pregnant rat myometrium

Bóta, J., Hajagos-Tóth, J., Ducza, E., Samavati, R., Borsodi, A., Benyhe, S. & Gáspár, R., Dec 15 2015, In : European Journal of Pharmacology. 769, p. 177-184 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2014

Effects of synthetic analogues of human opiorphin on rat brain opioid receptors

Benyhe, Z., Toth, G., Wollemann, M., Borsodi, A., Helyes, Z., Rougeot, C. & Benyhe, S., 2014, In : Journal of Physiology and Pharmacology. 65, 4, p. 525-530 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
8 Citations (Scopus)

Knockout subtraction autoradiography: A novel ex vivo method to detect heteromers finds sparse KOP receptor/DOP receptor heterodimerization in the brain

Yoo, J. H., Bailey, A., Borsodi, A., Tóth, G., Matifas, A., Kieffer, B. L. & Kitchen, I., May 15 2014, In : European Journal of Pharmacology. 731, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Low dosage of rimonabant leads to anxiolytic-like behavior via inhibiting expression levels and G-protein activity of kappa opioid receptors in a cannabinoid receptor independent manner

Zádor, F., Lénárt, N., Csibrány, B., Sántha, M., Molnár, M., Tuka, B., Samavati, R., Klivényi, P., Vécsei, L., Marton, A., Vizler, C., Nagy, G. M., Borsodi, A., Benyhe, S. & Páldy, E., Feb 2014, In : Neuropharmacology. 89, p. 298-307 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
23 Citations (Scopus)

Minocycline Enhances the Effectiveness of Nociceptin/Orphanin FQ during Neuropathic Pain

Popiolek-Barczyk, K., Rojewska, E., Jurga, A. M., Makuch, W., Zador, F., Borsodi, A., Piotrowska, A., Przewlocka, B. & Mika, J., Jan 1 2014, In : BioMed research international. 2014, 762930.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Novel cyclic biphalin analogue with improved antinociceptive properties

Mollica, A., Carotenuto, A., Novellino, E., Limatola, A., Costante, R., Pinnen, F., Stefanucci, A., Pieretti, S., Borsodi, A., Samavati, R., Zador, F., Benyhe, S., Davis, P., Porreca, F. & Hruby, V. J., Sep 11 2014, In : ACS Medicinal Chemistry Letters. 5, 9, p. 1032-1036 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2013

CNR1 gene deletion affects the density of endomorphin-2 binding sites in the mouse brain in a hemisphere-specific manner

Paldy, E., Borcel, E., Higuera-Matas, A., López-Montoya, G., Wenger, T., Toth, G., Borsodi, A. & Ambrosio, E., Jan 5 2013, In : European Journal of Pharmacology. 698, 1-3, p. 220-227 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Hybrid peptides endomophin-2/DAMGO: Design, synthesis and biological evaluation

Mollica, A., Costante, R., Stefanucci, A., Pinnen, F., Luisi, G., Pieretti, S., Borsodi, A., Bojnik, E. & Benyhe, S., Sep 26 2013, In : European Journal of Medicinal Chemistry. 68, p. 167-177 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Kainic acid-induced seizure activity alters the mRNA expression and G-protein activation of the opioid/nociceptin receptors in the rat brain cortex

Bayrakdar, E. T., Bojnik, E., Armagan, G., Kanit, L., Benyhe, S., Borsodi, A. & Yalcin, A., Jul 1 2013, In : Epilepsy Research. 105, 1-2, p. 13-19 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Synthesis, pharmacological evaluation and conformational investigation of endomorphin-2 hybrid analogues

Lesma, G., Salvadori, S., Airaghi, F., Bojnik, E., Borsodi, A., Recca, T., Sacchetti, A., Balboni, G. & Silvani, A., Feb 1 2013, In : Molecular Diversity. 17, 1, p. 19-31 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2012

A novel μ-opioid receptor ligand with high in vitro and in vivo agonist efficacy

Lackó, E., Váradi, A., Rapavi, R., Zádor, F., Riba, P., Benyhe, S., Borsodi, A., Hosztafi, S., Timár, J., Noszál, B., Fürst, S. & Al-Khrasani, M., Jan 1 2012, In : Current medicinal chemistry. 19, 27, p. 4699-4707 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures

Bojnik, E., Turunç, E., Armaĝan, G., Kanit, L., Benyhe, S., Yalçin, A. & Borsodi, A., Mar 1 2012, In : Epilepsy Research. 99, 1-2, p. 64-68 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Dopamine abnormalities in the neocortex of patients with temporal lobe epilepsy

Rocha, L., Alonso-Vanegas, M., Villeda-Hernández, J., Mújica, M., Cisneros-Franco, J. M., López-Gómez, M., Zavala-Tecuapetla, C., Frías-Soria, C. L., Segovia-Vila, J. & Borsodi, A., Jan 1 2012, In : Neurobiology of Disease. 45, 1, p. 499-507 9 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Kainic acid-induced changes in the opioid/nociceptin system and the stress/toxicity pathways in the rat hippocampus

Armagan, G., Bojnik, E., Turunc, E., Kanit, L., Gündüz Çinar, Ö., Benyhe, S., Borsodi, A. & Yalcin, A., May 1 2012, In : Neurochemistry international. 60, 6, p. 555-564 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Mu opioid receptor mRNA expression, binding, and functional coupling to G-proteins in human epileptic hippocampus

Cuellar-Herrera, M., Velasco, A. L., Velasco, F., Chavez, L., Orozco-Suarez, S., Armagan, G., Turunc, E., Bojnik, E., Yalcin, A., Benyhe, S., Borsodi, A., Alonso-Vanegas, M. & Rocha, L., Feb 1 2012, In : Hippocampus. 22, 2, p. 122-127 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

ßarrestin1-biased agonism at human δ-opioid receptor by peptidic and alkaloid ligands

Aguila, B., Coulbault, L., Davis, A., Marie, N., Hasbi, A., Le bras, F., Tóth, G., Borsodi, A., Gurevich, V. V., Jauzac, P. & Allouche, S., Mar 1 2012, In : Cellular Signalling. 24, 3, p. 699-707 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2011

Phylogenetic diversity and functional efficacy of the C-terminally expressed heptapeptide unit in the opioid precursor polypeptide proenkephalin A

Bojnik, E., Boynik, E., Corbani, M., Babos, F., Magyar, A., Borsodi, A. & Benyhe, S., Mar 31 2011, In : Neuroscience. 178, p. 56-67 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2010

Agonist-dependent attenuation of μ-opioid receptor-mediated G-protein activation in the dorsal root ganglia of neuropathic rats

Obara, I., Gunduz Cinar, O., Starowicz, K., Benyhe, S., Borsodi, A. & Przewlocka, B., Apr 1 2010, In : Journal of neural transmission. 117, 4, p. 421-429 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Bioinformatic and biochemical studies on the phylogenetic variability of proenkephalin-derived octapeptides

Bojnik, E., Babos, F., Magyar, A., Borsodi, A. & Benyhe, S., Jan 20 2010, In : Neuroscience. 165, 2, p. 542-552 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Comparative biochemical and pharmacological characterization of a novel, NOP receptor selective hexapeptide, Ac-RYYRIR-ol

Bojnik, E., Babos, F., Fischetti, C., Magyar, A., Camarda, V., Borsodi, A., Bajusz, S., Calo', G. & Benyhe, S., Mar 16 2010, In : Brain Research Bulletin. 81, 4-5, p. 477-483 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Nociceptin inhibits uterine contractions in term-pregnant rats by signaling through multiple pathways

Klukovits, A., Tekes, K., Gündüz Çinar, Ö., Benyhe, S., Borsodi, A., Deák, B. H., Hajagos-Tóth, J., Verli, J., Falkay, G. & Gáspár, R., Jul 2010, In : Biology of Reproduction. 83, 1, p. 36-41 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2009

Binding studies of novel, non-mammalian enkephalins, structures predicted from frog and lungfish brain cDNA sequences

Bojnik, E., Magyar, A., Tóth, G., Bajusz, S., Borsodi, A. & Benyhe, S., Jan 23 2009, In : Neuroscience. 158, 2, p. 867-874 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Selective and high affinity labeling of neuronal and recombinant nociceptin receptors with the hexapeptide radioprobe [3H]Ac-RYYRIK-ol

Bojnik, E., Farkas, J., Magyar, A., Tömböly, C., Güçlü, Ü., Gündüz, Ö., Borsodi, A., Corbani, M. & Benyhe, S., Dec 2009, In : Neurochemistry international. 55, 7, p. 458-466 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex

Rocha, L., Orozco-Suarez, S., Alonso-Vanegas, M., Villeda-Hernandez, J., Gaona, A., Páldy, E., Benyhe, S. & Borsodi, A., Sep 1 2009, In : Neurobiology of Disease. 35, 3, p. 466-473 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2008
33 Citations (Scopus)

Noladin ether, a putative endocannabinoid, inhibits μ-opioid receptor activation via CB2 cannabinoid receptors

Páldyová, E., Bereczki, E., Sántha, M., Wenger, T., Borsodi, A. & Benyhe, S., Jan 1 2008, In : Neurochemistry international. 52, 1, p. 321-328 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2007
7 Citations (Scopus)
2 Citations (Scopus)

Effects of nociceptin on the spread and seizure activity in the rat amygdala kindling model: Their correlations with 3H-leucyl-nociceptin binding

Carmona-Aparicio, L., Peña, F., Borsodi, A. & Rocha, L., Dec 1 2007, In : Epilepsy Research. 77, 2-3, p. 75-84 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

In vitro and in vivo pharmacological profile of UFP-512, a novel selective δ-opioid receptor agonist; correlations between desensitization and tolerance

Aguila, B., Coulbault, L., Boulouard, M., Liveilli, F., Davis, A., Toth, G., Borsodi, A., Balboni, G., Salvadori, S., Jauzac, P. & Allouche, S., Dec 1 2007, In : British journal of pharmacology. 152, 8, p. 1312-1324 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Novel diastereomeric opioid tetrapeptides exhibit differing pharmacological activity profiles

Ioja, E., Tourwé, D., Kertész, I., Tóth, G., Borsodi, A. & Benyhe, S., Sep 14 2007, In : Brain Research Bulletin. 74, 1-3, p. 119-129 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Opioid receptor binding in parahippocampus of patients with temporal lobe epilepsy: Its association with the antiepileptic effects of subacute electrical stimulation

Rocha, L., Cuellar-Herrera, M., Velasco, M., Velasco, F., Velasco, A. L., Jiménez, F., Orozco-Suarez, S. & Borsodi, A., Oct 1 2007, In : Seizure. 16, 7, p. 645-652 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
10 Citations (Scopus)

β-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent δ opioid antagonists

Tóth, G., Ioja, E., Tömböly, C., Ballet, S., Tourwé, D., Péter, A., Martinek, T., Chung, N. N., Schiller, P. W., Benyhe, S. & Borsodi, A., Jan 25 2007, In : Journal of Medicinal Chemistry. 50, 2, p. 328-333 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2006

In vitro and in vivo pharmacological characterization of the nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-ol

Gündüz, Ö., Rizzi, A., Baldisserotto, A., Guerrini, R., Spagnolo, B., Gavioli, E. C., Kocsis, L., Magyar, A., Benyhe, S., Borsodi, A. & Calò, G., Jun 6 2006, In : European Journal of Pharmacology. 539, 1-2, p. 39-48 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

In vitro binding and functional studies of Ac-RYYRIK-ol and its derivatives, novel partial agonists of the nociceptin/orphanin F/Q receptor

Gündüz, Ö., Sipos, F., Spagnolo, B., Kocsis, L., Magyar, A., Orosz, G., Borsodi, A., Calò, G. & Benyhe, S., Aug 1 2006, In : NeuroSignals. 15, 2, p. 91-101 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Opioid receptor binding characteristics and structure-activity studies of novel tetrapeptides in the TIPP (Tyr-Tic-Phe-Phe) series

Ioja, E., Tóth, G., Benyhe, S., Tourwe, D., Péter, A., Tömböly, C. & Borsodi, A., Jun 1 2006, In : NeuroSignals. 14, 6, p. 317-328 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Synthesis of enzymatically resistant nociceptin-related peptides containing a carbamic acid residue

Ligeti, M., Bösze, S., Csámpai, A., Gündüz, Ö., Al-Khrasani, M., Rónai, A. Z., Medzihradszky-Schweiger, H., Benyhe, S., Borsodi, A., Hudecz, F. & Magyar, A., Jul 1 2006, In : Journal of Peptide Science. 12, 7, p. 481-490 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2005

Autoradiography in opioid triple knockout mice reveals opioid and opioid receptor like binding of naloxone benzoylhydrazone

Cox, V., Clarke, S., Czyzyk, T., Ansonoff, M., Nitsche, J., Hsu, M. S., Borsodi, A., Tömböly, C., Tóth, G., Hill, R., Pintar, J. & Kitchen, I., Feb 2005, In : Neuropharmacology. 48, 2, p. 228-235 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Pregnancy-induced decrease in the relaxant effect of terbutaline in the late-pregnant rat myometrium: Role of G-protein activation and progesterone

Gáspár, R., Ducza, E., Mihályi, A., Márki, Á., Kolarovszki-Sipiczki, Z., Páldy, E., Benyhe, S., Borsodi, A., Földesi, I. & Falkay, G., Jul 1 2005, In : Reproduction. 130, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Synthesis and biological studies of nociceptin derivatives containing the DTPA chelating group for further labeling with therapeutic radionuclides

Ligeti, M., Gündüz, Ö., Magyar, A., Kató, E., Rónai, A. Z., Vita, C., Varga, I., Hudecz, F., Tóth, G., Borsodi, A. & Benyhe, S., Jul 1 2005, In : Peptides. 26, 7, p. 1159-1166 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)